Clinical and molecular characteristics of emerging hypervirulent Klebsiella pneumoniae bloodstream infections in mainland China

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 9, 2014, Pages 5379-5385

  Liu, Ying Mei ^a,b   Li, Bin Bin ^a   Zhang, Yu Yu ^a   Zhang, Wu ^a   Shen, Hong ^a   Li, Hui ^a   Cao, Bin ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Beijing Institute of Respiratory Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; CEFAZOLIN; CEFEPIME; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CIPROFLOXACIN; COTRIMOXAZOLE; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; MINOCYCLINE; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SULTAMICILLIN; TETRACYCLINE; TIMENTIN; TOBRAMYCIN; BETA LACTAMASE;

ADULT; ALLELE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLOODSTREAM INFECTION; CHINA; CLINICAL FEATURE; COMMUNITY ACQUIRED INFECTION; CONTROLLED STUDY; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA PNEUMONIAE; FEMALE; GENE SEQUENCE; HUMAN; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SEROTYPE; BACTEREMIA; COMMUNICABLE DISEASES, EMERGING; COMMUNITY-ACQUIRED INFECTIONS; GENETICS; KLEBSIELLA INFECTIONS; MICROBIOLOGY; MIDDLE AGED; RETROSPECTIVE STUDY; VIRULENCE;

ALLELES; BACTEREMIA; BETA-LACTAMASES; CHINA; COMMUNICABLE DISEASES, EMERGING; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; VIRULENCE;

EID: 84906087506     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02523-14     Document Type: Article

References (30)

1. Podschun R, Ullmann U. 1998. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin. Microbiol. Rev. 11:589-603. (Pubitemid 28497563)
2. Donnenberg MS. 2010. Enterobacteriaceae, p 2815-2833. In Mandell GL, Bennett JE, Dolin R (ed), Principles and practice of infectious diseases, 7th ed. Churchill-Livingstone, Philadelphia, PA.
3. Liu YC, Cheng DL, Lin CL. 1986. Klebsiella pneumoniae liver abscess associated with septic endophthalmitis. Arch. Intern. Med. 146: 1913-1916. http://dx.doi.org/10.1001/archinte.1986.00360220057011.
4. Yeh KM, Kurup A, Siu LK, Koh YL, Fung CP, Lin JC, Chen TL, Chang FY, Koh TH. 2007. Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan. J. Clin. Microbiol. 45:466-471. http://dx.doi.org/10.1128/JCM.01150-06.
5. Chung DR, Lee SS, Lee HR, Kim HB, Choi HJ, Eom JS, Kim JS, Choi YH, Lee JS, Chung MH, Kim YS, Lee H, Lee MS, Park CK, Korean Study Group for Liver Abscess. 2007. Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea. J. Infect. 54:578-583. http://dx.doi.org/10.1016/j.jinf. 2006.11.008. (Pubitemid 46731226)
6. Shon AS, Bajwa RP, Russo TA. 2013. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence 15:107-118. http://dx.doi.org/10.4161/viru.22718.
7. Cheng DL, Liu YC, Yen MY, Liu CY, Wang RS. 1991. Septicmetastatic lesions of pyogenic liver abscess. Their association with Klebsiella pneumoniae bacteraemia in diabetic patients. Arch. Intern. Med. 151:1557-1559.
8. Decré D, Verdet C, Emirian A, Le Gourrierec T, Petit JC, Offenstadt G, Maury E, Brisse S, Arlet G. 2011. Emerging severe and fatal infections due to Klebsiella pneumoniae in two university hospitals in France. J. Clin. Microbiol. 49:3012-3014. http://dx.doi.org/10.1128/JCM.00676-11.
9. Vila A, Cassata A, Pagella H, Amadio C, Yeh KM, Chang FY, Siu LK. 2011. Appearance of Klebsiella pneumoniae liver abscess syndrome in Argentina: case report and review of molecular mechanisms of pathogenesis. Open Microbiol. J. 5:107-113. http://dx.doi.org/10.2174/1874285801105010107.
10. Chang L, Bastian I, Warner M. 2013. Survey of Klebsiella pneumoniae bacteraemia in two South Australian hospitals and detection of hypermucoviscous phenotype and magA/rmpA genotypes in K. pneumoniae isolates. Infection 41:559-563. http://dx.doi.org/10.1007/s15010-012-0374-y.
11. McCabe R, Lambert L, Frazee B. 2010. Invasive Klebsiella pneumoniae infections, California, USA. Emerg. Infect. Dis. 16:1490-1491. http://dx.doi.org/10.3201/eid1609.100386.
12. Clinical and Laboratory Standards Institute. 2012. Performance standards for antimicrobial susceptibility testing; 22nd informational supplement. CLSI M100-S22. CLSI, Wayne, PA.
13. Fang CT, Lai SY, Yi WC, Hsueh PR, Liu KL, Chang SC. 2007. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin. Infect. Dis. 45:284-293. http://dx.doi.org/10.1086/519262.
14. Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S. 2005. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J. Clin. Microbiol. 43:4178-4182. http://dx.doi.org/10.1128/JCM.43.8.4178-4182.2005. (Pubitemid 41129719)
15. Feil EJ, Li BC, Aanensen DM, Hanage WP, Spratt BG. 2004. eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data. J. Bacteriol. 186:1518-1530. http://dx.doi.org/10.1128/JB.186.5.1518-1530.2004. (Pubitemid 38248742)
16. Yu VL, Hansen DS, Ko WC, Sagnimeni A, Klugman KP, von Gottberg A, Goossens H, Wagener MM, Benedi VJ, International Klebsiella Study Group. 2007. Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections, Emerg. Infect. Dis. 13:986-993. http://dx.doi.org/10.3201/eid1307.070187. (Pubitemid 47048070)
17. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, Swaminathan B. 1989. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
18. Nassif X, Honoré N, Vasselon T, Cole ST, Sansonetti PJ. 1989. Positive control of colanic acid synthesis in Escherichia coli by rmpA and rmpB, two virulence-plasmid genes of Klebsiella pneumoniae. Mol. Microbiol. 3:1349-1359. http://dx.doi.org/10.1111/j.1365-2958.1989.tb00116.x.
19. Li W, Sun G, Yu Y, Li N, Chen M, Jin R, Jiao Y, Wu H. 2014. Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin. Infect. Dis. 58:225-232. http://dx.doi.org/10.1093/cid/cit675.
20. Pan YJ, Fang HC, Yang HC, Lin TL, Hsieh PF, Tsai FC, Keynan Y, Wang JT. 2008. Capsular polysaccharide synthesis regions in Klebsiella pneumoniae serotype K57 and a new capsular serotype. J. Clin. Microbiol. 46:2231-2240. http://dx.doi.org/10.1128/JCM.01716-07.
21. Chuang YP, Fang CT, Lai SY, Chang SC, Wang JT. 2006. Genetic determinants of capsular serotype K1 of Klebsiella pneumoniae causing primary pyogenic liver abscess. J. Infect. Dis. 193:645-654. http://dx.doi.org/10.1086/499968.
22. Cheng NC, Yu YC, Tai HC, Hsueh PR, Chang SC, Lai SY, Yi WC, Fang CT. 2012. Recent trend of necrotizing fasciitis in Taiwan: focus on monomicrobial Klebsiella pneumoniae necrotizing fasciitis. Clin. Infect. Dis. 55:930-939. http://dx.doi.org/10.1093/cid/cis565.
23. Lin CJ, Lin CY, Li WY, Hsiue HC, Huang YT, Ruan SY, Wang JT, Hsueh PR. 2009. Repeated bacteraemia with subsequent septic arthritis caused by Klebsiella pneumoniae capsular serotype K57 in a patient with diabetes. Clin. Infect. Dis. 49:1284-1286. http://dx.doi.org/10.1086/605689.
24. Chen YJ, Chen SY, Wang JT, Hsueh PR. 2009. Mycotic aneurysm caused by gas-forming serotype K5 Klebsiella pneumoniae. Int. J. Infect. Dis. 13:e47-e48. http://dx.doi.org/10.1016/j.ijid.2008.06.008.
25. Hsu CR, Lin TL, Chen YC, Chou HC, Wang JT. 2011. The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited. Microbiology 157:3446-3457. http://dx.doi.org/10.1099/mic.0.050336-0.
26. Ko WC, Paterson DL, Sagnimeni AJ, Hansen DS, Von Gottberg A, Mohapatra S, Casellas JM, Goossens H, Mulazimoglu L, Trenholme G, Klugman KP, McCormack JG, Yu VL. 2002. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg. Infect. Dis. 8:160-166. http://dx.doi.org/10.3201/eid0802.010025. (Pubitemid 34202438)
27. Lee HC, Chuang YC, Yu WL, Lee NY, Chang CM, Ko NY, Wang LR, Ko WC. 2006. Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community-acquired bacteraemia. J. Intern. Med. 259:606-614. http://dx.doi.org/10.1111/j.1365- 2796.2006.01641.x.
28. Turton JF, Englender H, Gabriel SN, Turton SE, Kaufmann ME, Pitt TL. 2007. Genetically similar isolates of Klebsiella pneumoniae serotype K1 causing liver abscesses in three continents. J. Med. Microbiol. 56:593-597. http://dx.doi.org/10.1099/jmm.0.46964-0. (Pubitemid 46717480)
29. Lau YJ, Hu BS, Wu WL, Lin YH, Chang HY, Shi ZY. 2000. Identification of a major cluster of Klebsiella pneumoniae isolates from patients with liver abscess in Taiwan. J. Clin. Microbiol. 38:412-414.
30. Cheng HP, Chang FY, Fung CP, Siu LK. 2002. Klebsiella pneumoniae liver abscess in Taiwan is not caused by a clonal spread strain. J. Microbiol. Immunol. Infect. 35:85-88.