Prasugrel but not high dose clopidogrel overcomes the lansoprazole neutralizing effect of P2Y12 inhibition: Results of the randomized DOSAPI study

European Journal of Clinical Pharmacology

Volumn 70, Issue 9, 2014, Pages 1049-1057

  Collet, Jean Philippe ^a   Hulot, Jean Sébastien ^a,b   Abtan, Jérémie ^a   Anzaha, Ghalia ^a   Kerneis, Mathieu ^a   Silvain, Johanne ^a   Cayla, Guillaume ^a   O'Connor, Stephen A ^a   Barthélémy, Olivier ^a   Beygui, Farzin ^a   Galier, Sophie ^a   Brugier, Delphine ^a   Stanek, Eric J ^c   Charland, Scott L ^c   Gallois, Vanessa ^a   Montalescot, Gilles ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c Medco Health Solutions   (United States)

Author keywords

Coronary artery disease; Platelet reactivity; Proton pump inhibitor; Thienopyridine

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; CYTOCHROME P450 2C19; LANSOPRAZOLE; PLACEBO; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; THIENOPYRIDINE DERIVATIVE; ANTITHROMBOCYTIC AGENT; ANTIULCER AGENT; P2RY12 PROTEIN, HUMAN; PIPERAZINE DERIVATIVE; PURINERGIC P2Y RECEPTOR ANTAGONIST; THIOPHENE DERIVATIVE; TICLOPIDINE;

ADULT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EXPOSURE; DRUG MEGADOSE; ENZYME INHIBITION; FACTORIAL DESIGN; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; PHARMACODYNAMICS; PLATELET INHIBITION; PLATELET REACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESIDUAL PLATELET REACTIVITY; STOMACH ACID; STOMACH PROTECTION; THROMBOCYTE FUNCTION AND CHARACTERISTICS; TREATMENT DURATION; AGED; ANALOGS AND DERIVATIVES; DRUG EFFECTS; DRUG INTERACTION; MIDDLE AGED; THROMBOCYTE ACTIVATION;

ADULT; AGED; ANTI-ULCER AGENTS; ASPIRIN; CORONARY ARTERY DISEASE; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; FEMALE; HUMANS; LANSOPRAZOLE; MALE; MIDDLE AGED; PIPERAZINES; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2Y12; THIOPHENES; TICLOPIDINE;

EID: 84906082589     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-014-1710-1     Document Type: Article

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