Impact of gastric acid-suppressing therapies on platelet reactivity in patients with coronary artery disease treated with clopidogrel: Results of a pharmacodynamic study

Journal of the American College of Cardiology

Volumn 58, Issue 13, 2011, Pages 1396-1398

  Pham, John Paul ^b   Ueno, Masafumi ^b   Tello Montoliu, Antonio ^b   Ferreiro, José Luis ^b   Tomasello, Salvatore D ^b   Dharmashankar, Kodlipet ^b   Kodali, Murali ^b   Seecheran, Naveen ^b   Capodanno, Davide ^b   Desai, Bhaloo ^b   Bass, Theodore A ^b   Angiolillo, Dominick J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CIMETIDINE; CLOPIDOGREL; OMEPRAZOLE; RANITIDINE;

CONTROLLED STUDY; CORONARY ARTERY DISEASE; HUMAN; LETTER; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; OPEN STUDY; PHARMACODYNAMICS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

CORONARY ARTERY DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HUMANS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PROTON PUMP INHIBITORS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TICLOPIDINE; TREATMENT OUTCOME;

EID: 80052989922     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.06.031     Document Type: Letter

References (5)

1. E.R. Bates, W.C. Lau, and D.J. Angiolillo Clopidogrel-drug interactions J Am Coll Cardiol 57 2011 1251 1263
2. D.J. Angiolillo, C.M. Gibson, and S. Cheng Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies Clin Pharmacol Ther 89 2011 65 74
3. J.L. Ferreiro, and D.J. Angiolillo Antiplatelet therapy: clopidogrel plus PPIsa dangerous combination? Nat Rev Cardiol 6 2009 392 394
4. N.S. Abraham, M.A. Hlatky, and E.M. Antman ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents J Am Coll Cardiol 56 2010 2051 2066
5. L. Bonello, U.S. Tantry, R. Marcucci Working Group on High On-Treatment Platelet Reactivity Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate J Am Coll Cardiol 56 2010 919 933