Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model

Odontology

Volumn 102, Issue 2, 2014, Pages 310-317

  Boonyagul, Sani ^a   Banlunara, Wijit ^a   Sangvanich, Polkit ^a   Thunyakitpisal, Pasutha ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Acemannan; Aloe vera; BMSC; Differentiation; Mineralization; Tooth socket healing

Indexed keywords

ACEMANNAN; BONE MORPHOGENETIC PROTEIN 2; BONE SIALOPROTEIN; MANNAN; OSTEOPONTIN;

ALOE; ANIMAL; BONE DENSITY; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EXTRACELLULAR MATRIX; HEMATOPOIETIC STEM CELL; ISOLATION AND PURIFICATION; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT; TOOTH EXTRACTION;

ALOE; ANIMALS; BONE DENSITY; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL PROLIFERATION; EXTRACELLULAR MATRIX; HEMATOPOIETIC STEM CELLS; INTEGRIN-BINDING SIALOPROTEIN; MALE; MANNANS; OSTEOPONTIN; RATS; RATS, SPRAGUE-DAWLEY; TOOTH EXTRACTION;

EID: 84906075297     PISSN: 16181247     EISSN: 16181255     Source Type: Journal    
DOI: 10.1007/s10266-012-0101-2     Document Type: Article

References (24)

1. Mendes RM, Silva GA, Lima MF, et al. Sodium hyaluronate accelerates the healing process in tooth sockets of rats. Arch Oral Biol. 2008;53: 1155-62.
2. Bodner L, Kaffe I, Littner MM, Cohen J. Extraction site healing in rats. A radiologic densitometric study. Oral Surg Oral Med Oral Pathol. 1993;75: 367-72.
3. Kasugai S, Todescan R Jr, Nagata T, et al. Expression of bone matrix proteins associated with mineralized tissue formation by adult rat bone marrow cells in vitro: inductive effects of dexamethasone on the osteoblastic phenotype. J Cell Physiol. 1991;147: 111-20.
4. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276: 71-4.
5. Reynolds T, Dweck AC. Aloe vera leaf gel: a review update. J Ethnopharmacol. 1999;68: 3-37.
6. Jettanacheawchankit S, Sasithanasate S, Sangvanich P, Banlunara W, Thunyakitpisal P. Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. J Pharmacol Sci. 2009;109: 525-31.
7. Jittapiromsak N, Sahawat D, Banlunara W, Sangvanich P, Thunyakitpisal P. Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Tissue Eng Part A. 2010;16: 1997-2006.
8. Jittapiromsak N, Jettanacheawchankit S, Lardungdee P, Sangevanich P, Thunyakitpisal P. Effect of acemannan on BMP-2 expression in primary pupal fibroblasts and periodontal fibroblasts, in vitro study. J Oral Tissue Eng. 2007;4: 149-54.
9. Tai-Nin Chow J, Williamson DA, Yates KM, Goux WJ. Chemical characterization of the immunomodulating polysaccharide of Aloe vera L. Carbohydr Res. 2005;340: 1131-42.
10. Ozawa S, Kasugai S. Evaluation of implant materials (hydroxyapatite, glass-ceramics, titanium) in rat bone marrow stromal cell culture. Biomaterials. 1996;17: 23-9.
11. Lennon DP, Caplan AI. Mesenchymal stem cells for tissue engineering. In: Vunjak-Novakovic G, Freshney RI, editors. Culture of specialized cells: culture of cells for tissue engineering. Hoboken: Wiley; 2006. p. 30.
12. Shui C, Spelsberg TC, Riggs BL, Khosla S. Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res. 2003;18: 213-21.
13. Sato D, Nishimura K, Ishioka T, et al. Local application of simvastatin to rat incisor socket: carrier-dependent effect on bone augmentation. J Oral Tissue Eng. 2005;2: 81-5.
14. Lerouxel E, Libouban H, Moreau MF, et al. Mandibular bone loss in an animal model of male osteoporosis (orchidectomized rat): a radiographic and densitometric study. Osteoporos Int. 2004;15: 814-9.
15. Wu Z, Liu C, Zang G, Sun H. The effect of simvastatin on remodelling of the alveolar bone following tooth extraction. Int J Oral Maxillofac Surg. 2008;37: 170-6.
16. Deckers MML, Karperien M, van der Bent C, et al. Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinology. 2000;141: 1667-74.
17. Frank O, Heim M, Jakob M, et al. Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro. J Cell Biochem. 2002;85: 737-46.
18. Lecoeur L, Ouhayoun JP. In vitro induction of osteogenic differentiation from non-osteogenic mesenchymal cells. Biomaterials. 1997;18: 989-93.
19. Hunter GK, Goldberg HA. Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein. Biochem J. 1994;302(Pt 1): 175-9.
20. Hunter GK, Kyle CL, Goldberg HA. Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. Biochem J. 1994;300(Pt 3): 723-8.
21. Amler MH. The time sequence of tissue regeneration in human extraction wounds. Oral Surg Oral Med Oral Pathol. 1969;27: 309-18.
22. Guglielmi G, Gluer CC, Majumdar S, Blunt BA, Genant HK. Current methods and advances in bone densitometry. Eur Radiol. 1995;5: 129-39.
23. Keogh MB, O'Brien FJ, Daly JS. A novel collagen scaffold supports human osteogenesis-applications for bone tissue engineering. Cell Tissue Res. 2010;340: 169-77.
24. Lin WL, McCulloch CA, Cho MI. Differentiation of periodontal ligament fibroblasts into osteoblasts during socket healing after tooth extraction in the rat. Anat Rec. 1994;240: 492-506.