Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing

Journal of Pharmacological Sciences

Volumn 109, Issue 4, 2009, Pages 525-531

  Jettanacheawchankit, Suwimon ^a   Sasithanasate, Siriruk ^a   Sangvanich, Polkit ^a   Banlunara, Wijit ^a   Thunyakitpisal, Pasutha ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Acemannan; Aloe vera; Growth factor; Oral wound healing; Proliferation

Indexed keywords

ACEMANNAN; CARBOMER; COLLAGEN TYPE 1; KERATINOCYTE GROWTH FACTOR; SODIUM CHLORIDE; THYMIDINE; TRIAMCINOLONE ACETONIDE; TRITIUM; VASCULOTROPIN;

ALOE VERA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GINGIVA; GINGIVA ULCER; HARD PALATE; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PUNCH BIOPSY; RAT; SPRAGUE DAWLEY RAT; WOUND HEALING;

EID: 66249125012     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08204FP     Document Type: Article

References (32)

1. Singer AJ, Clark RAF. Cutaneous wound healing. N Engl J Med. 1999;341:738-746.
2. Aukhil I. Biology of wound healing. Periodontol 2000. 2000; 22:44-50.
3. Little JW. Complementary and alternative medicine: impact on dentistry. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:137-145.
4. Bae JS, Jang KH, Park SC, Jin HK. Promotion of dermal wound healing by polysaccharides isolated from Phellinus gilvus in rats. J Vet Med Sci. 2005;67:111-114.
5. Trombetta D, Puglia C, Perri D, Licata A, Pergolizzi S, Lauriano ER, et al. Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat. Phytomedicine. 2006;13:352-358.
6. Reynolds T, Dweck AC. Aloe vera leaf gel: a review update. J Ethnopharmacol. 1999;68:3-37.
7. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem. 1998;181:71-76.
8. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J Ethnopharmacol. 1998;59:179-186.
9. Femenia A, Sanchez ES, Simal S, Rossello C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissue. Carbohydrate Polymers. 1999;39:109-117.
10. Zhang L, Tizard IR. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 1996;35:119-128.
11. Djeraba A, Quere P. In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera. Int J Immunopharmacol. 2000;22:365-372.
12. Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int Immunopharmacol. 2004;4:1745-1755.
13. Tai-Nin Chow J, Williamson DA, Yates KM, Goux WJ. Chemical characterization of the immunomodulating polysaccharide of Aloe vera L. Carbohydr Res. 2005;340:1131-1142.
14. Jittapiromsak N, Jettanacheawchankit S, Lardungdee P, Sangvanich P, Thunyakitpisal P. Effect of acemannan on BMP-2 expression in primary pulpal fibroblasts and periodontal fibroblasts, in vitro study. J Oral Tissue Engin. 2007;4:149-154.
15. Yoshizumi M, Kagami S, Suzaki Y, Tsuchiya K, Houchi H, Hisayama T, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000;84:146-155.
16. Oda Y, Kagami H, Ueda M. Accelerating effects of basic fibroblast growth factor on wound healing of rat palatal mucosa. J Oral Maxillofac Surg. 2004;62:73-80.
17. Parnell LKS, Chinnah AD, Tizard IR. Use of mouse footpad model to test effectiveness of wound dressings. Wounds. 2002;14:177-186.
18. Regan JD, Chu EHY. A convenient method for assay of DNA synthesis in synchronized human cell cultures. J Cell Biol. 1966;28:139-143.
19. Abdullah KM, Abdullah A, Johnson ML, Bilski JJ, Petry K, Redmer DA, et al. Effects of Aloe vera on gap junctional intercellular communication and proliferation of human diabetic and nondiabetic skin fibroblasts. J Altern Complement Med. 2003;9:711-718.
20. Fogleman RW, Shellenberger TE, Balmer MF, Carpenter RH, McAnalley BH. Subchronic oral administration of acemannan in the rat and dog. Vet Hum Toxicol. 1992;34:144-147.
21. Werner S. Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev. 1998; 9:153-165.
22. Pierce GF, Yanagihara D, Klopchin K, Danilenko DM, Hsu E, Kenney WC, et al. Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor. J Exp Med. 1994;179:831-840.
23. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581-611.
24. Rossiter H, Barresi C, Pammer J, Rendl M, Haigh J, Wagner EF, et al. Loss of vascular endothelial growth factor a activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation. Cancer Res. 2004;64:3508-3516.
25. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol. 2004;164:1935-1947.
26. Lee JK, Lee MK, Yun YP, Kim Y, Kim JS, Kim YS, et al. Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Int Immunopharmacol. 2001;1:1275-1284.
27. Carbopol® 934P NF Polymer. Available at: http://www.pharma.lubrizol. com/ProductOverview/Carbopol934PNF.pdf Accessed July 17, 2008
28. Pal K, Banthia AK, Majumdar DK. Hydrogels for biomedical applications: a short review. J Mater Sci Mater Med. In press.
29. Scully C. Clinical practice. Aphthous ulceration. N Engl J Med. 2006;355:165-172.
30. Dickson A. Oral mucosa. In: Garant PR, editor. Oral cells and tissues. Chicago: Quintessense; 2003. p. 81.
31. East L, Isacke CM. The mannose receptor family. Biochim Biophys Acta. 2002;1572:364-386.
32. Boskovic J, Arnold JN, Stilion R, Gordon S, Sim RB, Rivera-Calzada A, et al. Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. J Biol Chem. 2006;281:8780-8787.