Resistance exercise restores endothelial function and reduces blood pressure in type 1 diabetic rats

Arquivos Brasileiros de Cardiologia

Volumn 103, Issue 1, 2014, Pages 25-32

  Mota, Marcelo Mendonç ^a   da Silva, Tharciano Luiz Teixeira Braga ^a   Fontes, Milene Tavares ^a   Barreto, André Sales ^a   Araújo, João Eliakim dos Santos ^a   de Oliveira, Antônio Cesar Cabral ^a   Wichi, Rogério Brandão ^a   Santos, Márcio Roberto Viana ^a  

^a FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

Author keywords

Arterial pressure physiology; Diabetes; Endothelium; Exercise; Physical endurance; Rats; Vascular physiology

Indexed keywords

ACETYLCHOLINE; DICLOFENAC; GLUCOSE; N (G) NITROARGININE METHYL ESTER; NITRIC OXIDE; UNCLASSIFIED DRUG; CHOLINERGIC RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; GLUCOSE BLOOD LEVEL; N(G) NITROARGININE METHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING ORGAN SYSTEMS; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR CATHETER; CONTROLLED STUDY; ELECTROSTIMULATION; ENDOTHELIAL FUNCTION; ENDURANCE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MESENTERIC ARTERY; MUSCLE RELAXATION; NONHUMAN; RAT; RELAXATION TRAINING; RESISTANCE TRAINING; SITTING; VASCULAR RING; ANIMAL; BLOOD PRESSURE; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SUPERIOR MESENTERIC ARTERY; VASCULAR ENDOTHELIUM; WISTAR RAT;

ACETYLCHOLINE; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CHOLINERGIC AGONISTS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; MALE; MESENTERIC ARTERY, SUPERIOR; MODELS, ANIMAL; NG-NITROARGININE METHYL ESTER; PHYSICAL CONDITIONING, ANIMAL; RATS, WISTAR; RESISTANCE TRAINING;

EID: 84906070289     PISSN: 0066782X     EISSN: 16784170     Source Type: Journal    
DOI: 10.5935/abc.20140087     Document Type: Article

References (40)

1. De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130(5):963-74.
2. Kumar S, Singh R, Vasudeva N, Sharma S. Acute and chronic animal models for the evaluation of anti-diabetic agents. Cardiovasc Diabetol. 2012;11:9.
3. Tesfamariam B, Brown ML, Cohen RA. Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest. 1991;87(5):1643-8.
4. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1996;97(1):22-8.
5. Tang EH, Vanhoutte PM. Endothelial dysfunction: a strategic target in thetreatment of hypertension? Pflugers Arch. 2010;459(6):995-1004.
6. Schram N, Chaturvedi C, Schalkwijk C, Giorgino F, Ebeling P, Fuller JH, et al. Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB prospective complications study. Diabetes Care. 2003;26(7):2165-73.
7. Matheus AS, Tannus LR, Cobas RA, Palma CC, Negrato CA, Gomes Mde B. Impact of diabetes on cardiovascular disease: an update. Int J Hypertens. 2013;2013:653789.
8. Farrell PA, Fedele MJ, Hernandez J, Fluckey JD, Miller JL 3rd, Lang CH, et al. Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise. J Appl Physiol. 1999;87(3):1075-82.
9. Braith RW, Stewart KJ. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation. 2006;113(22):2642-50.
10. Araujo AJ, Santos AC, Souza KS, Aires MB, Santana-Filho VJ, Fioretto ET, et al. Resistance training controls arterial blood pressure from L-NAME induced hypertensive rats. Arq Bras Cardiol. 2013;100(4):339-46.
11. Hall KE, McDonald MW, Grisé KN, Campos OA, Noble EG, Melling CW. The role of resistance and aerobic exercise training on insulin sensitivity measures in STZ-induced Type 1 diabetic rodents. Metabolism. 2013;62(10):1485-94.
12. Mann S, Beedie C, Balducci S, Zanuso S, Allgrove J, Bertiato F, et al. Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev. 2013; Oct 15. [Epub ahead of print].
13. Fuchsjäger-Mayrl G, Pleiner J, Wiesinger GF, Sieder AE, Quittan M, Nuhr MJ, et al. Exercise training improves vascular endothelial function in patients with type 1 diabetes. Diabetes Care. 2002;25(10):1795-801.
14. Chakraphan D, Sridulyakul P, Thipakorn B, Bunnag S, Huxley VH, Patumraj S. Attenuation of endothelial dysfunction by exercise training in STZ-induced diabetic rats. Clin Hemorheol Microcirc. 2005;32(3):217-26.
15. Mota MM, Silva TL, Fontes MT, Barreto AS, Oliveira AC, Santos MR. Treinamento aeróbio previne alterações na vasodilatação dependente do endotélio em ratos diabéticos. Rev educ fis UEM. 2013;24(3).
16. da Silva Costa EC, Goncalves AA, Areas MA, Morgabel RG. Os efeitos da metformina sobre a dispersão do intervalo QT e QTc de ratos diabéticos. Arq Bras Cardiol. 2008;90(4):254-60.
17. Tamaki T, Uchiyama S, Nakano S. A weight-lifting exercise model for inducing hypertrophy in the hindlimb muscles of rats. Med Sci Sports Exerc. 1992;24(8):881-6.
18. Galdino GS, Duarte IDG, Perez AC. Participation of endogenous opioids in the antinociception induced by resistance exercise in rats. Braz J Med Biol Res. 2010;43(9):906-9.
19. Cássia Cypriano EPR, Padilha AS, de Oliveira EM, Vassallo DV, de Fúcio Lizardo JH. Cardiovascular adaptive responses in rats submitted to moderate resistance training. Eur J Appl Physiol. 2008;103(5):605-13.
20. Barauna VG, Junior ML, Costa Rosa LF, Casarini DE, Krieger JE, De Oliveira EM. Cardiovascular adaptations in rats submitted to a resistance-training model. Clin Exp Pharmacol Physiol. 2005;32(4):249-54.
21. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288(5789):373-6.
22. Howley ET. Type of activity: Resistance, aerobic and leisure versus occupational physical activity. Med Sci Sports Exerc. 2001;33(6):364-9.
23. Børsheim E, Bahr R. Effect of exercise intensity, duration and mode on post-exercise oxygen consumption. Sports Med. 2003;33(14):1037-60.
24. Castaneda C, Layne JE; Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care. 2002;25(12):2335-41.
25. Dunstan DW, Daly RM, Owen N, Jolley D, de Courten M, Shaw J, et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 2002;25(10):1729-36.
26. Sigal RJ, Kenny GP, Boulé NG, Wells GA, Prudhomme D, Fortier M, et al. Effects of aerobic training, resistance training, or bothon glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med. 2007;147(6):357-69.
27. Nishikawa T, Edelstein D, Brownlee M. The missing link: a single unifying mechanism for diabetic complications. Kidney Int Suppl. 2000;77:S26-30.
28. Lenzen S, Panten U. Alloxan: history and mechanism of action. Diabetologia. 1988;31(6):337-42.
29. Szkudelski T. The mechanism of alloxan and streptozotocin action in β cells of the rat pancreas. Physiol Res. 2001;50(6):536-46.
30. Winterbourn CC, Munday R. Glutathione-mediated redox cycling of alloxan. Mechanisms of superoxide dismutase inhibition and of metal-catalyzed OH. formation. Biochem Pharmacol. 1989;38(2):271-7.
31. Jensen TE, Richter EA. Regulation of glucose and glycogen metabolism during and after exercise. J Physiol. 2012;590(5):1069-76.
32. Ropelle ER, Pauli JR, Carvalheira JBC. Efeitos moleculares do exercício físico sobre as vias de sinalização insulínica. Motriz. 2005;11(1):49-55.
33. Gross JL, Silveiro SP, Camargo LL. Diabetes mellito: diagnóstico, classificação do controle glicêmico. Arq Bras Endrocrinol Metab. 2002;46(1):16-26.
34. De Angelis K, da Pureza DY, Flores LJ, Rodrigues B, Melo KF, Schaan BD, et al. Efeitos fisiológicos do treinamento físico em pacientes portadores de diabetes tipo 1. Arq Bras Endocrinol Metab. 2006;50(6):1005-13.
35. Lash JM, Bohlen HG. Structural and functional origins of suppressed acetylcholine vasodilation in diabetic rat intestinal arterioles. Circ Res. 1991;69(5):1259-68.
36. Cosentino F, Luscher TF. Endothelial dysfunction in diabetes mellitus. J Cardiovasc Pharmacol. 1998;32 Suppl 3:54-61.
37. Zguira MS, Vincent S, Le Douairon Lahaye S, Malarde L, Tabka Z, Saïag B. Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta. Cardiovasc Diabetol. 2013;12:32.
38. Faria T de O, Targueta GP, Angeli JK, Almeida EA, Stefanon I, Vassallo DV, et al. Acute resistance exercise reduces blood pressure and vascular reactivity, and increases endothelium-dependent relaxation in spontaneously hypertensive rats. Eur J Appl Physiol. 2010;110(2):359-66.
39. Chen SJ, Wu CC, Yen MH. Exercise training activates large-conductance calcium-activated K+ channels and enhances nitric oxide production in rat mesenteric artery and thoracic aorta. J Biomed Sci. 2001;8(3):248-55.
40. Halliwill JR, Mechanisms and clinical implications of postexercise hypotension in humans. Exerc Sports Sci Rev. 2001;29(2):65-70.