Association of aging, arterial stiffness, and cardiovascular disease: A review

Cardiology in Review

Volumn 22, Issue 5, 2014, Pages 223-232

  Veerasamy, Murugapathy ^a,b   Ford, Gary A ^a   Neely, Dermot ^c   Bagnall, Alan ^a,b   MacGowan, Guy ^b   Das, Rajiv ^b   Kunadian, Vijay ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b FREEMAN HOSPITAL   (United Kingdom)

^c NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

arterial stiffness; cardiovascular disease; coronary artery disease; coronary heart disease; vascular stiffness

Indexed keywords

AGING; ARTERIAL STIFFNESS; CORONARY DISEASE; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGING; CORONARY DISEASE; HUMANS; VASCULAR STIFFNESS;

EID: 84906068801     PISSN: 10615377     EISSN: 15384683     Source Type: Journal    
DOI: 10.1097/CRD.0000000000000009     Document Type: Review

References (98)

1. O'Rourke MF, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective. J Am Coll Cardiol. 2007;50:1-13. (Pubitemid 46963521)
2. Laurent S, Cockcroft J, Van Bortel L, et al; European Network for Noninvasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588-2605. (Pubitemid 44627304)
3. Mancia G, De Backer G, Dominiczak A, et al; Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105-1187. (Pubitemid 46924065)
4. Bank AJ, Wang H, Holte JE, et al. Contribution of collagen, elastin, and smooth muscle to in vivo human brachial artery wall stress and elastic modulus. Circulation. 1996;94:3263-3270. (Pubitemid 26427497)
5. Bank AJ, Kaiser DR, Rajala S, et al. In vivo human brachial artery elastic mechanics: effects of smooth muscle relaxation. Circulation. 1999;100:41-47. (Pubitemid 29297938)
6. Fleenor BS. Large elastic artery stiffness with aging: novel translational mechanisms and interventions. Aging Dis. 2013;4:76-83.
7. Xu C, Zarins CK, Pannaraj PS, et al. Hypercholesterolemia superimposed by experimental hypertension induces differential distribution of collagen and elastin. Arterioscler Thromb Vasc Biol. 2000;20:2566-2572.
8. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25:932-943. (Pubitemid 40627836)
9. Kalay N, Elcik D, Do?an A, et al. The effects of significant coronary stenosis and percutaneous coronary intervention on aortic stiffness. Turk Kardiyol Dern Ars. 2012;40:143-147.
10. Ando J, Yamamoto K. Flow detection and calcium signalling in vascular endothelial cells. Cardiovasc Res. 2013;99:260-268.
11. Dzau VJ. Significance of the vascular renin-angiotensin pathway. Hypertension. 1986;8:553-559. (Pubitemid 16066758)
12. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415. (Pubitemid 18090241)
13. Gurtner GH, Burke-Wolin T. Interactions of oxidant stress and vascular reactivity. Am J Physiol. 1991;260(4 pt 1):L207-L211.
14. Förstermann U, Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation. 2006;113:1708-1714.
15. Miyazaki H, Matsuoka H, Cooke JP, et al. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation. 1999;99:1141-1146. (Pubitemid 29120084)
16. Allison MA, Criqui MH, Wright CM. Patterns and risk factors for systemic calcified atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:331-336. (Pubitemid 38197587)
17. Post W, Bielak LF, Ryan KA, et al. Determinants of coronary artery and aortic calcification in the Old Order Amish. Circulation. 2007;115:717-724. (Pubitemid 46294762)
18. McEniery CM, McDonnell BJ, So A, et al; Anglo-Cardiff Collaboration Trial Investigators. Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals. Hypertension. 2009;53:524-531.
19. Safar ME, O'Rourke MF. Handbook of Hypertension, Volume 23: Arterial Stiffness in Hypertension. London, United Kingdom: Elsevier; 2006.
20. Nichols WW, O'Rourke MF. McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. Edinburgh, United Kingdom: Oxford University Press; 2005.
21. Bézie Y, Lamazière JM, Laurent S, et al. Fibronectin expression and aortic wall elastic modulus in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol. 1998;18:1027-1034. (Pubitemid 28323586)
22. Fischer GM, Llaurado JG. Collagen and elastin content in canine arteries selected from functionally different vascular beds. Circ Res. 1966;19:394-399.
23. Latham RD, Westerhof N, Sipkema P, et al. Regional wave travel and reflections along the human aorta: A study with six simultaneous micromanometric pressures. Circulation. 1985;72:1257-1269. (Pubitemid 16126806)
24. Laurent S, Boutouyrie P, Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension. 2005;45:1050-1055. (Pubitemid 40770302)
25. Grundmann RT (Ed.). Diagnosis, screening and treatment of abdominal, thoracoabdominal and thoracic aortic aneurysms (pp. 53-74). Rijeka, Croatia: InTech Europe. 2011.
26. Virmani R, Avolio AP, Mergner WJ, et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol. 1991;139:1119-1129.
27. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. Circulation. 2003;107:139-146. (Pubitemid 36070946)
28. Ferro G, Duilio C, Spinelli L, et al. Relation between diastolic perfusion time and coronary artery stenosis during stress-induced myocardial ischemia. Circulation. 1995;92:342-347.
29. Weber T, Auer J, O'Rourke MF, et al. Prolonged mechanical systole and increased arterial wave reflections in diastolic dysfunction. Heart. 2006;92:1616-1622. (Pubitemid 44629167)
30. Asmar R, Benetos A, Topouchian J, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension. 1995;26:485-490.
31. van der Heijden-Spek JJ, Staessen JA, Fagard RH, et al. Effect of age on brachial artery wall properties differs from the aorta and is gender dependent: a population study. Hypertension. 2000;35:637-642. (Pubitemid 30108161)
32. Cruickshank K, Riste L, Anderson SG, et al. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation. 2002;106:2085-2090. (Pubitemid 35192814)
33. Mohiaddin RH, Firmin DN, Longmore DB. Age-related changes of human aortic flow wave velocity measured noninvasively by magnetic resonance imaging. J Appl Physiol (1985). 1993;74:492-497. (Pubitemid 23059787)
34. Millasseau SC, Guigui FG, Kelly RP, et al. Noninvasive assessment of the digital volume pulse. Comparison with the peripheral pressure pulse. Hypertension. 2000;36:952-956.
35. Stevanov M, Baruthio J, Gounot D, et al. In vitro validation of MR measurements of arterial pulse-wave velocity in the presence of reflected waves. J Magn Reson Imaging. 2001;14:120-127. (Pubitemid 32709470)
36. Wenn CM, Newman DL. Arterial tortuosity. Australas Phys Eng Sci Med. 1990;13:67-70.
37. Chiu YC, Arand PW, Shroff SG, et al. Determination of pulse wave velocities with computerized algorithms. Am Heart J. 1991;121:1460-1470.
38. Van Bortel LM, Duprez D, Starmans-Kool MJ, et al. Clinical applications of arterial stiffness, Task Force III: recommendations for user procedures. Am J Hypertens. 2002;15:445-452. (Pubitemid 34478484)
39. Lehmann ED, Hopkins KD, Rawesh A, et al. Relation between number of cardiovascular risk factors/events and noninvasive Doppler ultrasound assessments of aortic compliance. Hypertension. 1998;32:565-569. (Pubitemid 28429150)
40. Vaitkevicius PV, Fleg JL, Engel JH, et al. Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation. 1993;88(4 pt 1):1456-1462. (Pubitemid 23296891)
41. Lehmann ED, Watts GF, Gosling RG. Aortic distensibility and hypercholesterolaemia. Lancet. 1992;340:1171-1172.
42. Theilade S, Lajer M, Persson F, et al. Arterial stiffness is associated with cardiovascular, renal, retinal, and autonomic disease in type 1 diabetes. Diabetes Care. 2013;36:715-721.
43. Zhang M, Bai Y, Ye P, et al. Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population. Clin Cardiol. 2011;34:622-627.
44. Oliver JJ, Webb DJ. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol. 2003;23:554-566. (Pubitemid 36438066)
45. Tardy Y, Meister JJ, Perret F, et al. Non-invasive estimate of the mechanical properties of peripheral arteries from ultrasonic and photoplethysmographic measurements. Clin Phys Physiol Meas. 1991;12:39-54.
46. Mackenzie IS, Wilkinson IB, Cockcroft JR. Assessment of arterial stiffness in clinical practice. QJM-Mon J Assoc Phys. 2002;95:67-74. (Pubitemid 34187779)
47. O'Rourke MF. Arterial Function in Health and Disease. Edinburgh: Churchill; 1982.
48. London G, Guerin A, Pannier B, et al. Increased systolic pressure in chronic uremia. Role of arterial wave reflections. Hypertension. 1992;20:10-19.
49. Wilkinson IB, MacCallum H, Hupperetz PC, et al. Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man. J Physiol. 2001;530(pt 3):541-550. (Pubitemid 32162340)
50. Gatzka CD, Cameron JD, Dart AM, et al. Correction of carotid augmentation index for heart rate in elderly essential hypertensives. ANBP2 Investigators. Australian Comparative Outcome Trial of Angiotensin-Converting Enzyme Inhibitor-and Diuretic-Based Treatment of Hypertension in the Elderly. Am J Hypertens. 2001;14(6 pt 1):573-577.
51. Wilkinson IB, MacCallum H, Flint L, et al. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol. 2000;525(pt 1):263-270. (Pubitemid 30311951)
52. Smulyan H, Marchais SJ, Pannier B, et al. Influence of body height on pulsatile arterial hemodynamic data. J Am Coll Cardiol. 1998;31:1103-1109. (Pubitemid 28212513)
53. Chen CH, Nevo E, Fetics B, et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation. 1997;95:1827-1836. (Pubitemid 27164400)
54. Chen CH, Ting CT, Nussbacher A, et al. Validation of carotid artery tonometry as a means of estimating augmentation index of ascending aortic pressure. Hypertension. 1996;27:168-175. (Pubitemid 26045913)
55. Pauca AL, O'Rourke MF, Kon ND. Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform. Hypertension. 2001;38:932-937. (Pubitemid 34258696)
56. Karamanoglu M, O'Rourke MF, Avolio AP, et al. An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man. Eur Heart J. 1993;14:160-167. (Pubitemid 23089501)
57. Hope SA, Tay DB, Meredith IT, et al. Use of arterial transfer functions for the derivation of central aortic waveform characteristics in subjects with type 2 diabetes and cardiovascular disease. Diabetes Care. 2004;27:746-751. (Pubitemid 38280544)
58. Hope SA, Meredith IT, Cameron JD. Effect of non-invasive calibration of radial waveforms on error in transfer-function-derived central aortic waveform characteristics. Clin Sci (Lond). 2004;107:205-211. (Pubitemid 39070938)
59. Apter JT. Correlation of visco-elastic properties with microscopic structure of large arteries. IV. Thermal responses of collagen, elastin, smooth muscle, and intact arteries. Circ Res. 1967;21:901-918.
60. Roach MR, Burton AC. The reason for the shape of the distensibility curves of arteries. Can J Biochem Physiol. 1957;35:681-690.
61. Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2010;121:505-511.
62. Wang KL, Cheng HM, Sung SH, et al. Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study. Hypertension. 2010;55:799-805.
63. Anderson SG, Sanders TA, Cruickshank JK. Plasma fatty acid composition as a predictor of arterial stiffness and mortality. Hypertension. 2009;53:839-845.
64. Willum-Hansen T, Staessen JA, Torp-Pedersen C, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation. 2006;113:664-670.
65. Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006;113:657-663.
66. Sutton-Tyrrell K, Najjar SS, Boudreau RM, et al; Health ABC Study. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation. 2005;111:3384-3390. (Pubitemid 40923391)
67. Meaume S, Benetos A, Henry OF, et al. Aortic pulse wave velocity predicts cardiovascular mortality in subjects 70 years of age. Arterioscler Thromb Vasc Biol. 2001;21:2046-2050. (Pubitemid 34219760)
68. Terai M, Ohishi M, Ito N, et al. Comparison of arterial functional evaluations as a predictor of cardiovascular events in hypertensive patients: the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study. Hypertens Res. 2008;31:1135-1145.
69. Boutouyrie P, Tropeano AI, Asmar R, et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension. 2002;39:10-15. (Pubitemid 34098081)
70. Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001;37:1236-1241. (Pubitemid 34163575)
71. Cardoso CR, Ferreira MT, Leite NC, et al. Prognostic impact of aortic stiffness in high-risk type 2 diabetic patients: The Rio de Janeiro Yype 2 Diabetes Cohort study. Diabetes Care. 2013;36:3772-3778.
72. Levisianou D, Foussas S, Skopelitis E, et al. Arterial stiffness predicts risk for long-term recurrence in patients with type 2 diabetes admitted for acute coronary event. Diabetes Res Clin Pract. 2013;99:315-320.
73. Roos CJ, Auger D, Djaberi R, et al. Relationship between LV diastolic function and arterial stiffness in asymptomatic patients with diabetes mellitus. Int J Cardiovasc Imaging. 2013;29:609-616.
74. Zoungas S, Cameron JD, Kerr PG, et al. Association of carotid intima-medial thickness and indices of arterial stiffness with cardiovascular disease outcomes in CKD. Am J Kidney Dis. 2007;50:622-630. (Pubitemid 47444462)
75. Pannier B, Guérin AP, Marchais SJ, et al. Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients. Hypertension. 2005;45:592-596. (Pubitemid 40411265)
76. Blacher J, Safar ME, Pannier B, et al. Prognostic significance of arterial stiffness measurements in end-stage renal disease patients. Curr Opin Nephrol Hypertens. 2002;11:629-634. (Pubitemid 35440845)
77. Shoji T, Emoto M, Shinohara K, et al. Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. J Am Soc Nephrol. 2001;12:2117-2124. (Pubitemid 32880348)
78. Shokawa T, Imazu M, Yamamoto H, et al. Pulse wave velocity predicts cardiovascular mortality: findings from the Hawaii-Los Angeles-Hiroshima study. Circ J. 2005;69:259-264. (Pubitemid 40410178)
79. Kaneko H, Yajima J, Oikawa Y, et al. Role of arterial stiffness and impaired renal function in the progression of new coronary lesions after percutaneous coronary intervention. Cardiovasc Interv Ther. 2013;28:56-62.
80. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318-1327.
81. Tedesco MA, Natale F, Di Salvo G, et al. Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness. J Hum Hypertens. 2004;18:469-473. (Pubitemid 39023193)
82. Christen AI, Armentano RL, Miranda A, et al. Arterial wall structure and dynamics in type 2 diabetes mellitus methodological aspects and pathophysiological findings. Curr Diabetes Rev. 2010;6:367-377.
83. Bruno RM, Penno G, Daniele G, et al. Type 2 diabetes mellitus worsens arterial stiffness in hypertensive patients through endothelial dysfunction. Diabetologia. 2012;55:1847-1855.
84. Yiu KH, Zhao CT, Chen Y, et al. Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2013;12:94.
85. Mansour AS, Yannoutsos A, Majahalme N, et al. Aortic stiffness and cardiovascular risk in type 2 diabetes. J Hypertens. 2013;31:1584-1592.
86. Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin- convertingenzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:145-153.
87. Hirata K, Vlachopoulos C, Adji A, et al. Benefits from angiotensin-converting enzyme inhibitor 'beyond blood pressure lowering': beyond blood pressure or beyond the brachial artery? J Hypertens. 2005;23:551-556. (Pubitemid 40684713)
88. Guerin AP, Blacher J, Pannier B, et al. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation. 2001;103:987-992. (Pubitemid 32183805)
89. Toyama K, Sugiyama S, Oka H, et al. Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease. PLoS One. 2012;7:e41369.
90. Edwards DG, Schofield RS, Magyari PM, et al. Effect of exercise training on central aortic pressure wave reflection in coronary artery disease. Am J Hypertens. 2004;17:540-543. (Pubitemid 38726171)
91. Mustata S, Chan C, Lai V, et al. Impact of an exercise program on arterial stiffness and insulin resistance in hemodialysis patients. J Am Soc Nephrol. 2004;15:2713-2718. (Pubitemid 41103378)
92. Wilkinson IB, Franklin SS, Cockcroft JR. Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension. 2004;44:112-116. (Pubitemid 39014221)
93. Laufs U, La Fata V, Plutzky J, et al. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998;97:1129-1135. (Pubitemid 28152885)
94. Mahmud A, Feely J. Arterial stiffness and the renin-angiotensin- aldosterone system. J Renin Angiotensin Aldosterone Syst. 2004;5:102-108. (Pubitemid 39406718)
95. Sugawara J, Maeda S, Otsuki T, et al. Effects of nitric oxide synthase inhibitor on decrease in peripheral arterial stiffness with acute lowintensity aerobic exercise. Am J Physiol Heart Circ Physiol. 2004;287: H2666-H2669. (Pubitemid 39557138)
96. Ho CT, Lin CC, Hsu HS, et al. Arterial stiffness is strongly associated with insulin resistance in Chinese-a population-based study (Taichung Community Health Study, TCHS). J Atheroscler Thromb. 2011;18:122-130.
97. Jensen-Urstad KJ, Reichard PG, Rosfors JS, et al. Early atherosclerosis is retarded by improved long-term blood glucose control in patients with IDDM. Diabetes. 1996;45:1253-1258. (Pubitemid 26296328)
98. Satoh N, Ogawa Y, Usui T, et al. Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect. Diabetes Care. 2003;26:2493-2499. (Pubitemid 37055444)