Fecal volatile organic compounds: A novel, cheaper method of diagnosing inflammatory bowel disease?

Expert Review of Clinical Immunology

Volumn 10, Issue 9, 2014, Pages 1129-1131

  Probert, Chris S J ^a   Reade, Sophie ^a   Ahmed, Iftikhar ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

diagnostic; feces; inflammatory bowel disease; novel; volatile organic compound

Indexed keywords

METAL OXIDE; VOLATILE ORGANIC COMPOUND;

DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; FECES ANALYSIS; HUMAN; INFLAMMATORY BOWEL DISEASE; IRRITABLE COLON; MASS FRAGMENTOGRAPHY; METABOLOME; NONHUMAN; ODOR; RELAPSE; REVIEW; SENSOR; ANALYSIS; ANIMAL; CHEMISTRY; DISEASE MODEL; FECES; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASES; INTESTINE; METABOLISM; MICROBIOLOGY; MICROFLORA;

ANIMALS; DISEASE MODELS, ANIMAL; FECES; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINES; METABOLOME; MICROBIOTA; ODORS; VOLATILE ORGANIC COMPOUNDS;

EID: 84906053598     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2014.943664     Document Type: Review

References (21)

1. Knights D, Lassen KG, Xavier RJ. Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome. Gut 2013;62(10):1505-10
2. Canavese G, Bassotti G, Astegiano M, et al. Inflammatory bowel disease: a proposal to facilitate the achievement of an unequivocal diagnosis. World J Gastroenterol 2013; 19(3):426-8
3. Nappo A, Iacoviello L, Fraterman A, et al. High-sensitivity C-reactive protein is a predictive factor of adiposity in children: results of the identification and prevention of dietary- and lifestyle-induced health effects in children and infants (IDEFICS) study. J Am Heart Assoc 2013; 2(3)):e000101
4. Waugh N, Cummins E, Royle P, et al. Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation. Health Technol Asses 2013;17(55)):xv-xix.1-211
5. Probert CSJ. Role of faecal gas analysis for the diagnosis of IBD. Biochem Soc Trans 2011;39:1079-80
6. Probert CSJ, Ahmed I, Khalid T, et al. Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases. J Gastrointest Liver Dis 2009; 18(3):337-43
7. Arasaradnam RP, Covington JA, Harmston C, Nwokolo CU. Review article: next generation diagnostic modalities in gastroenterology - gas phase volatile compound biomarker detection. Aliment Pharmacol Ther 2014;39(8):780-9
8. Ratcliffe NM, de Lacy Costello B, Shepherd S. The use of MS for the investigation of irritable bowel syndrome and inflammatory bowel disease. Clin Lab Int Magazine 2013;37:18-20
9. Altomare DF, Di Lena M, Porcelli F, et al. Exhaled volatile organic compounds identify patients with colorectal cancer. Br J Surg 2013;100(1):144-50
10. Khalid T, White P, De Lacy Costello B, et al. A pilot study combining a GC-sensor device with a statistical model for the identification of bladder cancer from urine headspace. PloS One 2013;8(7)):e69602
11. de Lacy Costello B, Ratcliffe N M. Volatile organic compounds (VOCs) found in urine and stool. In: Volatile biomarkers: non-invasive diagnosis in physiology and medicine 1st edn. Amann A, Smith D, Editors Amsterdam: Elsevier; 2013. Pp 405-62
12. Arasaradnam RP, Ouaret N, Thomas MG, et al. A novel tool for noninvasive diagnosis and tracking of patients with inflammatory bowel disease. Inflamm Bowel Dis 2013; 19(5):999-1003
13. Patel N, Cikach F, Eng K, et al. Metabolomic analysis of exhaled breath to identify volatile organic compounds (VOCs) in children with inflammatory bowel disease. Gastroenterology 2013;144(5): S710-0
14. Jayasena H, Khalid T, Probert CS. PTU-076 Diagnostic potential of volatile organic compounds as faecal biomarkers in inflammatory bowel disease. Gut 2013; 62(Suppl 1)):A75-6
15. Walton C, Fowler DP, Turner C, et al. Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis 2013;19(10): 2069-78
16. Garner CE, Smith S, Costello BD, et al. Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J 2007; 21(8):1675-88
17. Ahmed I, Greenwood R, Costello BD, et al. An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PloS One 2013;8(3)):e58204
18. Kinross JM, Darzi AW, Nicholson JK. Gut microbiome-host interactions in health and disease. Genome Med 2011;3(3):14
19. Ahmed I, Smith S, Probert CS. Volatile organic compounds as diagnostic faecal biomarkers in inflammatory bowel disease method development. Gut 2009;58:A63-3
20. Reade S, Mayor A, Aggio R, et al. Optimisation of sample preparation for direct SPME-GC-MS analysis of murine and human faecal volatile organic compounds for metabolomic studies. J Anal Bioanal Tech 2014;5(2)
21. Shepherd SF, McGuire ND, de Lacy Costello BP, et al. The use of a gas chromatograph coupled to a metal oxide sensor for rapid assessment of stool samples from irritable bowel syndrome and inflammatory bowel disease patients. J Breath Res 2014;8(2):026001