Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases

Inflammatory Bowel Diseases

Volumn 19, Issue 10, 2013, Pages 2069-2078

  Walton, Christopher ^a   Fowler, Dawn P ^a   Turner, Claire ^b   Jia, Wenjing ^c   Whitehead, Rebekah N ^d   Griffiths, Lesley ^d   Dawson, Claire ^e   Waring, Rosemary H ^d   Ramsden, David B ^d   Cole, Jeffrey A ^d   Cauchi, Michael ^a   Bessant, Conrad ^a   Hunter, John O ^e  

^a CRANFIELD UNIVERSITY   (United Kingdom)

^b OPEN UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Colitis; Crohn's disease; Fatty acids; Irritable bowel syndrome; Ulcerative; Volatile; Volatile organic compounds

Indexed keywords

ACETONE; ALCOHOL; BUTANOL; BUTYRIC ACID; DIMETHYLDISULPHIDE; ESTER; INDOLE; PARA CRESOL; PHENOL; PROPANOL; PROPIONIC ACID; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND;

ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; CROHN DISEASE; FECES ANALYSIS; FEMALE; GASTROINTESTINAL DISEASE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

BACTERIA; BACTERIAL INFECTIONS; CASE-CONTROL STUDIES; CHRONIC DISEASE; COLITIS, ULCERATIVE; CROHN DISEASE; FECES; FEMALE; FOLLOW-UP STUDIES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEALTHY VOLUNTEERS; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; PROGNOSIS; VOLATILE ORGANIC COMPOUNDS;

EID: 84884579240     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e31829a91f6     Document Type: Article

References (43)

1. Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489:220-230.
2. Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008;134:577-594.
3. Qin JJ, Li RQ, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:55-60.
4. Carroll IM, Ringel-Kulka T, Siddle JP, et al. Alterations in composition and diversity of the intestinal microbiota in patients with diarrheapredominant irritable bowel syndrome. Neurogastroenterol Motil. 2012; 24:521-530.
5. Mukhopadhya I, Hansen R, El-Omar EM, et al. IBD-what role do proteobacteria play? Nat Rev Gastroenterol Hepatol. 2012;9:219-230.
6. Kinross JM, Darzi AW, Nicholson JK. Gut microbiome-host interactions in health and disease. Genome Med. 2011;3:14.
7. Duchmann R, Kaiser I, Hermann E, et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol. 1995;102:448-455.
8. van der Waaij LA, Kroese FG, Visser A, et al. Immunoglobulin coating of faecal bacteria in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2004;16:669-674.
9. Dear KL, Elia M, Hunter JO. Do interventions which reduce colonic bacterial fermentation improve symptoms of irritable bowel syndrome? Dig Dis Sci. 2005;50:758-766.
10. Pimental M. Validation of an objective bowel composite score for his in studies involving treatment. Am J Gastroenterol. 2002;97:S276.
11. King TS, Elia M, Hunter JO. Abnormal colonic fermentation in irritable bowel syndrome. Lancet. 1998;352:1187-1189.
12. Nanda R, James R, Smith H, et al. Food intolerance and the irritable bowel syndrome. Gut. 1989;30:1099-1104.
13. Jones VA, Shorthouse M, McLaughlan P, et al. Food intolerance-a major factor in the pathogenesis of irritable bowel syndrome. Lancet. 1982;2: 1115-1117.
14. Hamer HM, De Preter V, Windey K, et al. Functional analysis of colonic bacterial metabolism: relevant to health? Am J Physiol Gastrointest Liver Physiol. 2012;302:G1-G9.
15. Kuzma J, Nemecek-Marshall M, Pollock WH, et al. Bacteria produce the volatile hydrocarbon isoprene. Curr Microbiol. 1995;30:97-103.
16. Carterson AJ, Morici LA, Jackson DW, et al. The transcriptional regulator AlgR controls cyanide production in Pseudomonas aeruginosa. J Bacteriol. 2004;186:6837-6844.
17. Cody WL, Pritchett CL, Jones AK, et al. Pseudomonas aeruginosa AlgR controls cyanide production in an AlgZ-dependent manner. J Bacteriol. 2009;191:2993-3002.
18. Smith EA, Macfarlane GT. Dissimilatory amino acid metabolism in human colonic bacteria. Anaerobe. 1997;3:327-337.
19. Bunge M, Araghipour N, Mikoviny T, et al. On-line monitoring of microbial volatile metabolites by proton transfer reaction-mass spectrometry. Appl Environ Microbiol. 2008;74:2179-2186.
20. Lechner M, Rieder J. Mass spectrometric profiling of low-molecularweight volatile compounds-diagnostic potential and latest applications. Curr Med Chem. 2007;14:987-995.
21. Scholler C, Molin S, Wilkins K. Volatile metabolites from some gramnegative bacteria. Chemosphere. 1997;35:1487-1495.
22. Pavlou AK, Magan N, McNulty C, et al. Use of an electronic nose system for diagnoses of urinary tract infections. Biosens Bioelectron. 2002;17:893-899.
23. Pavlou AK, Magan N, Jones JM, et al. Detection of mycobacterium tuberculosis (TB) in vitro and in situ using an electronic nose in combination with a neural network system. Biosens Bioelectron. 2004;20:538-544.
24. Reinhold P, Purkhart R, Kohler H, et al. Chronic intestinal mycobacteria infection: discrimination via VOC analysis in exhaled breath and headspace of feces using differential ion mobility spectrometry. J Breath Res. 2011;5:027103.
25. Garner CE, Smith S, Costello BD, et al. Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J. 2007;21:1675-1688.
26. Probert CS, Jones PR, Ratcliffe NM. A novel method for rapidly diagnosing the causes of diarrhoea. Gut. 2004;53:58-61.
27. Riordan AM, Hunter JO, Cowan RE, et al. Treatment of active Crohnsdisease by exclusion diet-East Anglian Multicenter Controlled Trial. Lancet. 1993;342:1131-1134.
28. Parker TJ, Naylor SJ, Riordan AM, et al. Management of patients with food intolerance in irritable-bowel-syndrome-the development and use of an exclusion diet. J Hum Nutr Diet. 1995;8:159-166.
29. Peakman TC, Elliott P. The UK biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. Int J Epidemiol. 2008;37:234-244.
30. Backhed F, Ley RE, Sonnenburg JL, et al. Host-bacterial mutualism in the human intestine. Science. 2005;307:1915-1920.
31. Mortensen PB, Clausen MR. Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease. Scand J Gastroenterol Suppl. 1996;31:132-148.
32. Suarez FL, Springfield J, Levitt MD. Identification of gases responsible for the odour of human flatus and evaluation of a device purported to reduce this odour. Gut. 1998;43:100-104.
33. Van Nuenen M, Venema K, Van der Woude CJ, et al. The metabolic activity of fecal microbiota from healthy individuals and patients with inflammatory bowel disease. Dig Dis Sci. 2004;49:485-491.
34. De Preter V, Van Staeyen G, Esser D, et al. Development of a screening method to determine the pattern of fermentation metabolites in faecal samples using on-line purge-and-trap gas chromatographic-mass spectrometric analysis. J Chromatogr A. 2009;1216:1476-1483.
35. Siegel S, Castellan NJ. Nonparametric Statistics for the Behavioural Sciences. 2nd ed. New York, NY: McGraw-Hill; 1988.
36. Lupton JR. Microbial degradation products influence colon cancer risk: the butyrate controversy. J Nutr. 2004;134:479-482.
37. Best CA, Laposata M. Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake. Front Biosci. 2003;8: E202-E217.
38. Lange LG, Sobel BE. Mitochondrial dysfunction induced by fatty-acid ethyl-esters, myocardial metabolites of ethanol. J Clin Invest. 1983;72: 724-731.
39. Lewis VJ, Moss CW, Jones WL. Determination of volatile acid production of Clostridium by gas chromatography. Can J Microbiol. 1967;13: 1033-1040.
40. Phillips KD, Tearle PV, Willis AT. Rapid diagnosis of anaerobic infections by gas-liquid-chromatography of clinical material. J Clin Pathol. 1976;29:428-432.
41. Gorbach SL, Mayhew JW, Bartlett JG, et al. Rapid diagnosis of anaerobic infections by direct gas-liquid-chromatography of clinical specimens. J Clin Invest. 1976;57:478-484.
42. Sondag JE, Ali M, Murray PR. Rapid presumptive identification of anaerobes in blood cultures by gas-liquid-chromatography. J Clin Microbiol. 1980;11:274-277.
43. Rehman A, Lepage P, Nolte A, et al. Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients. J Med Microbiol. 2010;59:1114-1122.