Expression of testicular androgen receptor in non-obstructive azoospermia and its change after hormonal therapy

Andrology

Volumn 2, Issue 5, 2014, Pages 734-740

  Kato, Y ^a   Shiraishi, K ^a   Matsuyama, H ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Androgen receptor; Azoospermia; Sertoli cell

Indexed keywords

ANDROGEN RECEPTOR; CHORIONIC GONADOTROPIN; GONADOTROPIN; RECOMBINANT FOLLITROPIN; VIMENTIN; FOLLITROPIN;

ADULT; ARTICLE; AZOOSPERMIA; CELL MATURATION; GERM CELL; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICRODISSECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERTOLI CELL; SPERM RETRIEVAL; SPERMATOCYTE; SPERMATOGONIUM; SPERMATOZOON; TESTICULAR SPERM EXTRACTION; BIOSYNTHESIS; METABOLISM; OLIGOSPERMIA; RETROSPECTIVE STUDY; SALVAGE THERAPY; UPREGULATION;

ADULT; AZOOSPERMIA; CHORIONIC GONADOTROPIN; FOLLICLE STIMULATING HORMONE, HUMAN; HUMANS; MALE; OLIGOSPERMIA; RECEPTORS, ANDROGEN; RETROSPECTIVE STUDIES; SALVAGE THERAPY; SERTOLI CELLS; SPERM RETRIEVAL; SPERMATOZOA; UP-REGULATION;

EID: 84906047385     PISSN: 20472919     EISSN: 20472927     Source Type: Journal    
DOI: 10.1111/j.2047-2927.2014.00240.x     Document Type: Article

References (34)

1. Aumuller G, Steinbruck M, Krause W & Wagner HJ. (1988) Distribution of vimentin-type intermediate filaments in Sertoli cells of the human testis, normal and pathologic. Anat Embryol 178, 129-136.
2. Blok U, Mackenbach P, Trapman J, Themmen APN, Brinkmann AO & Grootegoed JA. (1989) Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells. Mol Cell Endocrinol 63, 267-271.
3. Boukari K, Meduri G, Brailly-Tabard S, Guibourdenche J, Ciampi ML, Massin N, Martinerie L, Picard JY, Rey R, Lombès M & Young J. (2009) Lack of androgen receptor expression in Sertoli cells accounts for the absence of anti-Mullerian hormone repression during early human testis development. J Clin Endocrinol Metab 94, 1818-1825.
4. Bremner WJ, Millar MR, Sharpe RM & Saunders PT. (1994) Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens. Endocrinology 135, 1227-1234.
5. Chang C, Chen YT, Yeh SD, Xu Q, Wang RS, Guillou F, Lardy H & Yeh S. (2004) Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proc Natl Acad Sci USA 101, 6876-6881.
6. Chemes HE, Rey RA, Nistal M, Regadera J, Musse M, González- Peramato P & Serrano A. (2008) Physiological androgen insensitivity of the fetal, neonatal, and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells. J Clin Endocrinol Metab 93, 4408-4412.
7. De Gendt K, Swinnen JV, Saunders PT, Schoonjans L, Dewerchin M, Devos A, Tan K, Atanassova N, Claessens F, Lécureuil C, Heyns W, Carmeliet P, Guillou F, Sharpe RM & Verhoeven G. (2004) A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci USA 101, 1327-1332.
8. Dwyer AA, Sykiotis GP, Hayes FJ, Boepple PA, Lee H, Loughlin KR, Dym M, Sluss PM, Crowley WF Jr & Pitteloud N. (2013) Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 98, 1790-1795.
9. Griswold MD. (2005) Perspective on the function of Sertoli cells. In: Sertoli Cell Biology (eds MK Skinner & MD Griswold), pp. 15-18. Elsevier Science, San Diego, CA.
10. Guillaume E, Pineau C, Evrard B, Dupaix A, Moertz E, Sanchez JC, Hochstrasser DF & Jégou B. (2001) Cellular distribution of translationally controlled tumor protein in rat and human testes. Proteomics 1, 880-890.
11. Hazra R, Corcoran L, Robson M, McTavish KJ, Upton D, Handelsman DJ & Allan CM. (2013) Temporal role of Sertoli cell androgen receptor expression in spermatogenic development. Mol Endocrinol 27, 12-24.
12. Hill CM, Anway MD, Zirkin BR & Brown TR. (2004) Intratesticular androgen levels, androgen receptor localization, and androgen receptor expression in adult rat Sertoli cells. Biol Reprod 71, 1348-1358.
13. Holdcraft RW & Braun RE. (2004) Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development 131, 459-467.
14. Iwamura M, Abrahamsson PA, Benning M, Cockett AT & di Sant'Agnese PA. (1994) Androgen receptor immunostaining and its tissue distribution in formalin fixed, paraffin-embedded sections after microwave treatment. J Histochem Cytochem 42, 783-788.
15. Jarow JP, Chen H, Rosner TW, Trentacoste S & Zirkin BR. (2001) Assessment of the androgen environment within the human testis: minimally invasive method to obtain intratesticular fluid. J Androl 22, 640-645.
16. Kimura N, Mizokami A, Oonuma T, Sasano H & Nagura H. (1993) Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues. J Histochem Cytochem 41, 67l-678.
17. McLachlan RI, O'Donnell L, Meachem SJ, Stanton PG, de Kretser DM, Pratis K & Robertson DM. (2002) Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man. Recent Prog Horm Res 57, 149-179.
18. O'Shaughnessy PJ, Verhoeven G, de Gerndt K, Monteiro A & Abel MH. (2010) Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology 151, 2343-2348.
19. Plant TM & Marshall GR. (2001) The functional significance of FSH in spermatogenesis and the control of its secretion in male primates. Endocr Rev 22, 764-786.
20. Quigley CA, de Bellis A, Marschke KB, el-Awady MK, Wilson EM & French FS. (1995) Androgen receptor defects: historical, clinical and molecular perspectives. Endocr Rev 16, 271-321.
21. Rey RA, Musse M, Venara M & Chemes HE. (2009) Ontogeny of the androgen receptor expression in the fetal and postnatal testis: its relevance on Sertoli cell maturation and the onset of adult spermatogenesis. Microsc Res Tech 72, 787-795.
22. Ruizeveld de Winter JA, Trapman J, Vermey M, Mulder E, Zegers ND & van der Kwast TH. (1991) Androgen receptor expression in human tissues: an immunohistochemical study. J Histochem Cytochem 39, 927-936.
23. Schlegel PN. (1999) Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod 14, 131-135.
24. Sharpe RM. (2005) Sertoli cell endocrinology and signal transduction: androgen regulation. In: Sertoli Cell Biology (eds MK Skinner & MD Griswold), pp. 199-216. Elsevier Science, San Diego, CA.
25. Sharpe RM, McKinnell C, Kivlin C & Fisher JS. (2003) Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 125, 769-784.
26. Shinjo E, Shiraishi K & Matsuyama H. (2013) The effect of human chorionic gonadotropin-based hormonal therapy on intratesticular testosterone levels and spermatogonial DNA synthesis in men with non-obstructive azoospermia. Andrology 1, 929-935.
27. Shiraishi K, Ohmi C, Shimabukuro T & Matsuyama H. (2012) Human chorionic gonadotrophin treatment prior to microdissection testicular sperm extraction in non-obstructive azoospermia. Hum Reprod 27, 331-339.
28. Suarez-Quian CA, Martinez-Garcia F, Nistal M & Regadera J. (1999) Androgen receptor distribution in adult human testis. J Clin Endocrinol Metab 84, 350-358.
29. Takeda H, Chodak O, Mutchnik S, Nakamoto T & Chang C. (1989) Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor. J Endocrinol 126, 17-25.
30. Tsutsui K. (1991) Pituitary and gonadal hormone-dependent and -independent induction of follicle-stimulating hormone receptors in the developing testis. Endocrinology 128, 477-487.
31. Van Roijen JH, Van Assen S, Van Der Kwast TH, De Rooij DG, Boersma WJ, Vreeburg JT & Weber RF. (1995) Androgen receptor immunoexpression in the testes of subfertile men. J Androl 16, 510-516.
32. Verhoeven G, Willems A, Denolet E, Swinnen JV & De Gendt K. (2010) Androgens and spermatogenesis: lessons from transgenic mouse models. Philos Trans R Soc Lond B Biol Sci 365, 1537-1556.
33. Wang RS, Yeh S, Tzeng CR & Chang C. (2009) Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr Rev 30, 119-132.
34. Weedin JW, Bennett RC, Feing DM, Lamb DJ & Lipshultz LI. (2011) Early versus late maturation arrest: reproductive outcomes of testicular failure. J Urol 186, 621-626.