Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Rutten, Bert ^a   Tersteeg, Claudia ^a   Vrijenhoek, Joyce E P ^a,b   Van Holten, Thijs C ^a   Elsenberg, Ellen H A M ^a   Mak Nienhuis, Elske M ^a   De Borst, Gert Jan ^a   Jukema, J Wouter ^c   Pijls, Nico H J ^d   Waltenberger, Johannes ^e   Van Zonneveld, Anton Jan ^c   Moll, Frans L ^a   McClellan, Elizabeth ^f   Stubbs, Andrew ^f   Pasterkamp, Gerard ^a   Hoefer, Imo ^a   De Groot, Philip G ^a   Roest, Mark ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CATHARINA HOSPITAL   (Netherlands)

^e MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^f ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ATHEROSCLEROTIC PLAQUE; BLOOD; COHORT ANALYSIS; FEMALE; FLOW CYTOMETRY; HUMAN; MACROPHAGE; MALE; MIDDLE AGED; MONOCYTE; PATHOPHYSIOLOGY; PHYSIOLOGY; THROMBOCYTE;

AGED; BLOOD PLATELETS; COHORT STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; MACROPHAGES; MALE; MIDDLE AGED; MONOCYTES; PLAQUE, ATHEROSCLEROTIC;

EID: 84905993093     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105019     Document Type: Article

References (38)

1. Lusis AJ (2000) Atherosclerosis. Nature 407: 233-241.
2. Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352: 1685-1695.
3. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20: 1262-1275. (Pubitemid 30262927)
4. Massberg S, Brand K, Gruner S, Page S, Muller E, et al. (2002) A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med 196: 887-896.
5. Leppanen A, Mehta P, Ouyang YB, Ju T, Helin J, et al. (1999) A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin. J Biol Chem 274: 24838-24848.
6. Simon DI, Chen Z, Xu H, Li CQ, Dong J, et al. (2000) Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med 192: 193-204. (Pubitemid 30470302)
7. Liu D, Krummey SM, Badell IR, Wagener M, Schneeweis LA, et al. (2014) 2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses. J Exp Med.
8. Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, et al. (2003) Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9: 61-67. (Pubitemid 36098261)
9. Furman MI, Barnard MR, Krueger LA, Fox ML, Shilale EA, et al. (2001) Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol 38: 1002-1006. (Pubitemid 32912702)
10. Furman MI, Benoit SE, Barnard MR, Valeri CR, Borbone ML, et al. (1998) Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease. J Am Coll Cardiol 31: 352-358. (Pubitemid 28153455)
11. Michelson AD, Barnard MR, Krueger LA, Valeri CR, Furman MI (2001) Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 104: 1533-1537. (Pubitemid 32917347)
12. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964. (Pubitemid 41746764)
13. Antithrombotic Trialists' Collaboration (2002) Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324: 71-86.
14. Karanas YL, Yim KK, Shuster BA, Lineaweaver WC (1995) Lemierre's syndrome: a case of postanginal septicemia and bilateral flank abscesses. Ann Plast Surg 35: 525-528.
15. Burger PC, Wagner DD (2003) Platelet P-selectin facilitates atherosclerotic lesion development. Blood 101: 2661-2666. (Pubitemid 36857627)
16. Jones CI, Garner SF, Angenent W, Bernard A, Berzuini C, et al. (2007) Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. J Thromb Haemost 5: 1756-1765. (Pubitemid 47091421)
17. Van Holten TC, Roest M, Riphagen J, Jansen C, Naarding P, et al. (2012) Citalopram is a more potent platelet function inhibitor than paroxetine in a case-control study. J Thromb Haemost 10: 1177-1179.
18. Hoefer IE, Sels JW, Jukema JW, Bergheanu S, Biessen E, et al. (2013) Circulating cells as predictors of secondary manifestations of cardiovascular disease: design of the Circulating Cells study. Clin Res Cardiol.
19. Verhoeven BA, Velema E, Schoneveld AH, de Vries JP, de Bruin P, et al. (2004) Athero-express: differential atherosclerotic plaque expression of mRNA and protein in relation to cardiovascular events and patient characteristics. Rationale and design. Eur J Epidemiol 19: 1127-1133. (Pubitemid 40228502)
20. Goldstein MR (1995) Endarterectomy for asymptomatic carotid artery stenosis. Jama 274: 1505-1506; author reply 1506-1507.
21. Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJ (2004) Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 363: 915-924. (Pubitemid 38388324)
22. Hellings WE, Pasterkamp G, Vollebregt A, Seldenrijk CA, De Vries JP, et al. (2007) Intraobserver and interobserver variability and spatial differences in histologic examination of carotid endarterectomy specimens. J Vasc Surg 46: 1147-1154. (Pubitemid 350267075)
23. Klinkhardt U, Bauersachs R, Adams J, Graff J, Lindhoff-Last E, et al. (2003) Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease. Clin Pharmacol Ther 73: 232-241. (Pubitemid 36269674)
24. Braun OO, Johnell M, Varenhorst C, James S, Brandt JT, et al. (2008) Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease. Thromb Haemost 100: 626-633.
25. Li D, Wang Y, Zhang L, Luo X, Li J, et al. (2012) Roles of purinergic receptor P2Y, G protein-coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 32: e81-89.
26. Hechler B, Freund M, Ravanat C, Magnenat S, Cazenave JP, et al. (2008) Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors. Circulation 118: 754-763.
27. van Bladel ER, Laarhoven AG, van der Heijden LB, Heitink-Polle KM, Porcelijn L, et al. (2014) Functional platelet defects in children with severe chronic ITP as tested with two novel assays applicable for low platelet counts. Blood.
28. Breet NJ, van Werkum JW, Bouman HJ, Kelder JC, Ruven HJ, et al. (2010) Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. Jama 303: 754-762.
29. Dawood BB, Lowe GC, Lordkipanidze M, Bem D, Daly ME, et al. (2012) Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel. Blood 120: 5041-5049.
30. Can MM, Tanboga IH, Turkyilmaz E, Karabay CY, Akgun T, et al. (2010) The risk of false results in the assessment of platelet function in the absence of antiplatelet medication: comparison of the PFA-100, multiplate electrical impedance aggregometry and verify now assays. Thromb Res 125: e132-137.
31. Bouman HJ, Parlak E, van Werkum JW, Breet NJ, ten Cate H, et al. (2010) Which platelet function test is suitable to monitor clopidogrel responsiveness? A pharmacokinetic analysis on the active metabolite of clopidogrel. J Thromb Haemost 8: 482-488.
32. Davies JA, Collins PW, Hathaway LS, Bowen DJ (2009) C1584: effect on von Willebrand factor proteolysis and von Willebrand factor antigen levels. Acta Haematol 121: 98-101.
33. da Costa Martins PA, van Gils JM, Mol A, Hordijk PL, Zwaginga JJ (2006) Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol 79: 499-507. (Pubitemid 44831227)
34. Gawaz M, Neumann FJ, Dickfeld T, Koch W, Laugwitz KL, et al. (1998) Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells. Circulation 98: 1164-1171. (Pubitemid 28436165)
35. Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, et al. (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391: 591-594. (Pubitemid 28157601)
36. Frenette PS, Denis CV, Weiss L, Jurk K, Subbarao S, et al. (2000) P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med 191: 1413-1422. (Pubitemid 30227127)
37. von Hundelshausen P, Weber KS, Huo Y, Proudfoot AE, Nelson PJ, et al. (2001) RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103: 1772-1777. (Pubitemid 32291415)
38. von Hundelshausen P, Koenen RR, Sack M, Mause SF, Adriaens W, et al. (2005) Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood 105: 924-930. (Pubitemid 40170856)