High prevalence of reduced chlorhexidine susceptibility in organisms causing central line-associated bloodstream infections

Infection Control and Hospital Epidemiology

Volumn 35, Issue 9, 2014, Pages 1183-1186

  Suwantarat, Nuntra ^a   Carroll, Karen C ^a,b   Tekle, Tsigereda ^b   Ross, Tracy ^b   Maragakis, Lisa L ^a,b   Cosgrove, Sara E ^a,b   Milstone, Aaron M ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE GLUCONATE; CHLORHEXIDINE; TOPICAL ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ANTISEPTIC SUSCEPTIBILITY; BACTERIUM ISOLATE; CATHETER INFECTION; CITROBACTER FREUNDII; COAGULASE NEGATIVE STAPHYLOCOCCUS; CORYNEBACTERIUM STRIATUM; DRUG SENSITIVITY; ENTEROBACTER CLOACAE; ENTEROCOCCUS; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA PNEUMONIAE; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; METHICILLIN RESISTANT COAGULASE NEGATIVE STAPHYLOCOCCUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NOTE; PANTOEA AGGLOMERANS; PREVALENCE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS PUTIDA; SERRATIA MARCESCENS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS; STREPTOCOCCUS; VANCOMYCIN RESISTANT ENTEROCOCCUS; VANCOMYCIN SUSCEPTIBLE ENTEROCOCCUS; ANALOGS AND DERIVATIVES; ANTIBIOTIC RESISTANCE; BACTEREMIA; CENTRAL VENOUS CATHETERIZATION; CLINICAL TRIAL; CROSS INFECTION; DRUG EFFECTS; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; GRAM POSITIVE BACTERIUM; GRAM POSITIVE INFECTION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PROSPECTIVE STUDY;

ANTI-INFECTIVE AGENTS, LOCAL; BACTEREMIA; CATHETER-RELATED INFECTIONS; CATHETERIZATION, CENTRAL VENOUS; CHLORHEXIDINE; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MICROBIAL SENSITIVITY TESTS; PROSPECTIVE STUDIES;

EID: 84905989514     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/677628     Document Type: Note

References (10)

1. Milstone AM, Elward A, Song X, et al. Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomised, crossover trial. Lancet 2013;381:1099-1106.
2. Climo MW, Yokoe DS, Warren DK, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med 2013;368:533-542.
3. Horner C, Mawer D, Wilcox M. Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter? J Antimicrob Chemother 2012;67:2547-2559.
4. Apisarnthanarak A, Yang Hsu L, Lim TP, Mundy LM. Increase in chlorhexidine minimal inhibitory concentration of Acinetobacter baumannii clinical isolates after implementation of advanced source control. Infect Control Hosp Epidemiol 2014;35: 98-99.
5. Higgins CS, Murtough SM, Williamson E, et al. Resistance to antibiotics and biocides among non-fermenting gram-negative bacteria. Clin Microbiol Infect 2001;7:308-315.
6. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: 23rd Informational Supplement. Wayne, PA: CLSI, 2013. CLSI document M100-S23.
7. Alam MM, Kobayashi N, Uehara N, et al. Analysis on distribution and genomic diversity of high-level antiseptic resistance genes qacA and qacB in human clinical isolates of Staphylococcus aureus. Microb Drug Resist 2003;9:109-121.
8. Grare M, Dibama HM, Lafosse S, et al. Cationic compounds with activity against multidrug-resistant bacteria: interest of a new compound compared with two older antiseptics, hexamidine and chlorhexidine. Clin Microbiol Infect 2010;16:432-438.
9. Kõljalg S, Naaber P, Mikelsaar M. Antibiotic resistance as an indicator of bacterial chlorhexidine susceptibility. J Hosp Infect 2002;51:106-113.
10. Otter JA, Patel A, Cliff PR, Halligan EP, Tosas O, Edgeworth JD. Selection for qacA carriage in CC22, but not CC30, methicillin- resistant Staphylococcus aureus bloodstream infection isolates during a successful institutional infection control programme. J Antimicrob Chemother 2013;68:992-999.