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Volumn 20, Issue 16, 2014, Pages 4173-4175

CHK it out! Blocking WEE kinase routs TP53 mutant cancer

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; PROTEIN P53; UNCLASSIFIED DRUG; WEE KINASE; CELL CYCLE PROTEIN; NUCLEAR PROTEIN; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA;

EID: 84905973961     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0720     Document Type: Article
Times cited : (24)

References (12)
  • 1
    • 84905985785 scopus 로고    scopus 로고
    • Functional kinomics identifies candidate therapeutic targets in head and neck cancer
    • Moser R, Xu C, Kao M, Annis J, Lerma LA, Schaupp CM, et al. Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res 2014;20:4274-88.
    • (2014) Clin Cancer Res , vol.20 , pp. 4274-4288
    • Moser, R.1    Xu, C.2    Kao, M.3    Annis, J.4    Lerma, L.A.5    Schaupp, C.M.6
  • 4
    • 84855443905 scopus 로고    scopus 로고
    • TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence
    • Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, et al. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 2012;18:290-300.
    • (2012) Clin Cancer Res , vol.18 , pp. 290-300
    • Skinner, H.D.1    Sandulache, V.C.2    Ow, T.J.3    Meyn, R.E.4    Yordy, J.S.5    Beadle, B.M.6
  • 5
    • 80455162370 scopus 로고    scopus 로고
    • Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer
    • Sano D, Xie TX, Ow TJ, Zhao M, Pickering CR, Zhou G, et al. Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer. Clin Cancer Res 2011;17:6658-70.
    • (2011) Clin Cancer Res , vol.17 , pp. 6658-6670
    • Sano, D.1    Xie, T.X.2    Ow, T.J.3    Zhao, M.4    Pickering, C.R.5    Zhou, G.6
  • 6
    • 84884529410 scopus 로고    scopus 로고
    • Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53
    • Gadhikar MA, Sciuto MR, Alves MV, Pickering CR, Osman AA, Neskey DM, et al. Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53. Mol Cancer Ther 2013;12:1860-73.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1860-1873
    • Gadhikar, M.A.1    Sciuto, M.R.2    Alves, M.V.3    Pickering, C.R.4    Osman, A.A.5    Neskey, D.M.6
  • 8
    • 70949083026 scopus 로고    scopus 로고
    • Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
    • Hirai H, Iwasawa Y, Okada M, Arai T, Nishibata T, Kobayashi M, et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol Cancer Ther 2009;8:2992-3000.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2992-3000
    • Hirai, H.1    Iwasawa, Y.2    Okada, M.3    Arai, T.4    Nishibata, T.5    Kobayashi, M.6
  • 9
    • 80052491760 scopus 로고    scopus 로고
    • MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells
    • Bridges KA, Hirai H, Buser CA, Brooks C, Liu H, Buchholz TA, et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res 2011;17:5638-48.
    • (2011) Clin Cancer Res , vol.17 , pp. 5638-5648
    • Bridges, K.A.1    Hirai, H.2    Buser, C.A.3    Brooks, C.4    Liu, H.5    Buchholz, T.A.6
  • 10
    • 84858833041 scopus 로고    scopus 로고
    • Update on a phase I pharmacologic and pharmacodynamic study of MK-1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors
    • abstr 3068
    • Schellens J, Shapiro G, Pavlick A, Tibes R, Leijen S, Tolaney S, et al. Update on a phase I pharmacologic and pharmacodynamic study of MK-1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors. J Clin Oncol 29: 2011 (suppl; abstr 3068).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Schellens, J.1    Shapiro, G.2    Pavlick, A.3    Tibes, R.4    Leijen, S.5    Tolaney, S.6
  • 11
    • 84896031764 scopus 로고    scopus 로고
    • Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, incombination with gemcitabine inUSpatients with advanced solid tumors
    • Sausville E, Lorusso P, Carducci M, Carter J, Quinn MF, Malburg L, et al. Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, incombination with gemcitabine inUSpatients with advanced solid tumors. Cancer Chemother Pharmacol 2014;73:539-49.
    • (2014) Cancer Chemother Pharmacol , vol.73 , pp. 539-549
    • Sausville, E.1    Lorusso, P.2    Carducci, M.3    Carter, J.4    Quinn, M.F.5    Malburg, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.