-
1
-
-
84905985785
-
Functional kinomics identifies candidate therapeutic targets in head and neck cancer
-
Moser R, Xu C, Kao M, Annis J, Lerma LA, Schaupp CM, et al. Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res 2014;20:4274-88.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 4274-4288
-
-
Moser, R.1
Xu, C.2
Kao, M.3
Annis, J.4
Lerma, L.A.5
Schaupp, C.M.6
-
2
-
-
80052158097
-
The mutational landscape of head and neck squamous cell carcinoma
-
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science 2011;333:1157-60.
-
(2011)
Science
, vol.333
, pp. 1157-1160
-
-
Stransky, N.1
Egloff, A.M.2
Tward, A.D.3
Kostic, A.D.4
Cibulskis, K.5
Sivachenko, A.6
-
3
-
-
37349055876
-
TP53 mutations and survival in squamous-cell carcinoma of the head and neck
-
DOI 10.1056/NEJMoa073770
-
Poeta ML, Manola J, Goldwasser MA, Forastiere A, Benoit N, Califano JA, et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med 2007;357:2552-61. (Pubitemid 350294222)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.25
, pp. 2552-2561
-
-
Poeta, M.L.1
Manola, J.2
Goldwasser, M.A.3
Forastiere, A.4
Benoit, N.5
Califano, J.A.6
Ridge, J.A.7
Goodwin, J.8
Kenady, D.9
Saunders, J.10
Westra, W.11
Sidransky, D.12
Koch, W.M.13
-
4
-
-
84855443905
-
TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence
-
Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, et al. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 2012;18:290-300.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 290-300
-
-
Skinner, H.D.1
Sandulache, V.C.2
Ow, T.J.3
Meyn, R.E.4
Yordy, J.S.5
Beadle, B.M.6
-
5
-
-
80455162370
-
Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer
-
Sano D, Xie TX, Ow TJ, Zhao M, Pickering CR, Zhou G, et al. Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer. Clin Cancer Res 2011;17:6658-70.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6658-6670
-
-
Sano, D.1
Xie, T.X.2
Ow, T.J.3
Zhao, M.4
Pickering, C.R.5
Zhou, G.6
-
6
-
-
84884529410
-
Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53
-
Gadhikar MA, Sciuto MR, Alves MV, Pickering CR, Osman AA, Neskey DM, et al. Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53. Mol Cancer Ther 2013;12:1860-73.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 1860-1873
-
-
Gadhikar, M.A.1
Sciuto, M.R.2
Alves, M.V.3
Pickering, C.R.4
Osman, A.A.5
Neskey, D.M.6
-
7
-
-
0035890610
-
2 checkpoint abrogator
-
Wang Y, Li J, Booher RN, Kraker A, Lawrence T, Leopold WR, et al. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res 2001;61:8211-7. (Pubitemid 33091614)
-
(2001)
Cancer Research
, vol.61
, Issue.22
, pp. 8211-8217
-
-
Wang, Y.1
Li, J.2
Booher, R.N.3
Kraker, A.4
Lawrence, T.5
Leopold, W.R.6
Sun, Y.7
-
8
-
-
70949083026
-
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
-
Hirai H, Iwasawa Y, Okada M, Arai T, Nishibata T, Kobayashi M, et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol Cancer Ther 2009;8:2992-3000.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2992-3000
-
-
Hirai, H.1
Iwasawa, Y.2
Okada, M.3
Arai, T.4
Nishibata, T.5
Kobayashi, M.6
-
9
-
-
80052491760
-
MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells
-
Bridges KA, Hirai H, Buser CA, Brooks C, Liu H, Buchholz TA, et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res 2011;17:5638-48.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5638-5648
-
-
Bridges, K.A.1
Hirai, H.2
Buser, C.A.3
Brooks, C.4
Liu, H.5
Buchholz, T.A.6
-
10
-
-
84858833041
-
Update on a phase I pharmacologic and pharmacodynamic study of MK-1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors
-
abstr 3068
-
Schellens J, Shapiro G, Pavlick A, Tibes R, Leijen S, Tolaney S, et al. Update on a phase I pharmacologic and pharmacodynamic study of MK-1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors. J Clin Oncol 29: 2011 (suppl; abstr 3068).
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Schellens, J.1
Shapiro, G.2
Pavlick, A.3
Tibes, R.4
Leijen, S.5
Tolaney, S.6
-
11
-
-
84896031764
-
Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, incombination with gemcitabine inUSpatients with advanced solid tumors
-
Sausville E, Lorusso P, Carducci M, Carter J, Quinn MF, Malburg L, et al. Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, incombination with gemcitabine inUSpatients with advanced solid tumors. Cancer Chemother Pharmacol 2014;73:539-49.
-
(2014)
Cancer Chemother Pharmacol
, vol.73
, pp. 539-549
-
-
Sausville, E.1
Lorusso, P.2
Carducci, M.3
Carter, J.4
Quinn, M.F.5
Malburg, L.6
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