Cellular localization of 5α-reductase in the rat cerebellum

Journal of Chemical Neuroanatomy

Volumn 59-60, Issue , 2014, Pages 8-16

  Kiyokage, Emi ^a,c   Toida, Kazunori ^a,c   Suzuki Yamamoto, Toshiko ^b,c   Ishimura, Kazunori ^c  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

5 reductase type 1; Astrocytes; Bergmann glia; Cerebellum; Neurosteroids; Oligodendrocytes

Indexed keywords

STEROID 5ALPHA REDUCTASE 1; CHOLESTENONE 5ALPHA REDUCTASE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTROCYTE; CELLULAR DISTRIBUTION; CEREBELLUM; CEREBELLUM CORTEX; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GRANULE CELL; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERNEURON; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THIN LAYER CHROMATOGRAPHY; ANIMAL; BIOSYNTHESIS; BRAIN LEVEL; C57BL MOUSE; ENZYMOLOGY; GLIA; KNOCKOUT MOUSE; WISTAR RAT;

ANIMALS; BRAIN CHEMISTRY; CEREBELLUM; CHOLESTENONE 5 ALPHA-REDUCTASE; FEMALE; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROGLIA; PURKINJE CELLS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84905966810     PISSN: 08910618     EISSN: 18736300     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2014.04.002     Document Type: Article

References (53)

1. Agís-Balboa R.C., Pinna G., Zhubi A., Maloku E., Veldic M., Costa E., Guidotti A. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc. Natl. Acad. Sci. (U. S. A.) 2006, 103:14602-14607.
2. Altman J. Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer. J. Comp. Neurol. 1972, 145:353-397.
3. Angulo M.C., Kozlov A.S., Charpak S., Audinat E. Glutamate released from glial cells synchronizes neuronal activity in the hippocampus. J. Neurosci. 2004, 24:6920-6927.
4. Baulieu E.E. Neurosteroids: a new function in the brain. Biology of the Cell 1991, Review.
5. Belelli D., Lambert J.J. Neurosteroids: endogenous regulators of the GABA (A) receptor. Nat. Rev. Neurosci. 2005, 6:565-575. Review.
6. Castelli M.P., Casti A., Casu A., Frau R., Bortolato M., Spiga S., Ennas M.G. Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis. Psychoneuroendocrinology 2013, 38:281-293.
7. Celotti F., Melcangi R.C., Martini L. The 5 alpha-reductase in the brain: molecular aspects and relation to brain function. Front. Neuroendocrinol. 1992, 13:163-215. Review.
8. Celotti F., Negri-Cesi P., Poletti A. Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization. Brain Res. Bull. 1997, 44:365-375. Review.
9. Gago N., Akwa Y., Sananès N., Guennoun R., Baulieu E.E., El-Etr M., Schumacher M. Progesterone and the oligodendroglial lineage: stage-dependent biosynthesis and metabolism. Glia 2001, 36:295-308.
10. Girdler S.S., Klatzkin R. Neurosteroids in the context of stress: implications for depressive disorders. Pharmacol. Ther. 2007, 116:125-139. Review.
11. Griffin L.D., Gong W., Verot L., Mellon S.H. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nat. Med. 2004, 7:704-711.
12. Gunn B.G., Brown A.R., Lambert J.J., Belelli D. Neurosteroids and GABA(A) receptor interactions: a focus on stress. Front. Neurosci. 2011, 5:131.
13. Hajszan T., Milner T.A., Leranth C. Sex steroids and the dentate gyrus. Prog. Brain Res. 2007, 163:399-415. Review.
14. Kimoto T., Ishii H., Higo S., Hojo Y., Kawato S. Semicomprehensive analysis of the postnatal age-related changes in the mRNA expression of sex steroidogenic enzymes and sex steroid receptors in the male rat hippocampus. Endocrinology 2010, 151:5795-5806.
15. Kiyokage E., Toida K., Suzuki-Yamamoto T., Ishimura K. Localization of 5alpha-reductase in the rat main olfactory bulb. J. Comp. Neurol. 2005, 493:381-395.
16. Kosaka T., Kosaka K., Nakayama T., Hunziker W., Heizmann C.W. Axons and axon terminals of cerebellar Purkinje cells and basket cells have higher levels of parvalbumin immunoreactivity than somata and dendrites: quantitative analysis by immunogold labeling. Exp. Brain Res. 1993, 93:483-491.
17. Kosaka K., Aika Y., Toida K., Heizmann C.W., Hunziker W., Jacobowitz D.M., Nagatsu I., Streit P., Visser T.J., Kosaka T. Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb. Neurosci. Res. 1995, 23:73-88.
18. Kozlov A.S., Angulo M.C., Audinat E., Charpak S. Target cell-specific modulation of neuronal activity by astrocytes. Proc. Natl. Acad. Sci. (U. S. A.) 2006, 103:10058-10063.
19. Lephart E.D. Pituitary and brain 5alpha-reductase messenger RNA levels in control, castrated, and dihydrotestosterone-treated rats. Mol. Cell.Neurosci. 1993, 4:526-531.
20. Lippman J.J., Lordkipanidze T., Buell M.E., Yoon S.O., Dunaevsky A. Morphogenesis and regulation of Bergmann glial processes during Purkinje cell dendritic spine ensheathment and synaptogenesis. Glia 2008, 56:1463-1477.
21. Lordkipanidze T., Dunaevsky A. Purkinje cell dendrites grow in alignment with Bergmann glia. Glia 2005, 51:229-234.
22. Mahendroo M.S., Cala K.M., Russell D.W. 5 alpha-reduced androgens play a key role in murine parturition. Mol. Endocrinol. 1996, 10:380-392.
23. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1986, 232:1004-1007.
24. McCarthy M.M. Estradiol and the developing brain. Physiol. Rev. 2008, 88:91-124. Review.
25. Melcangi R.C., Celotti F., Ballabio M., Poletti A., Castano P., Martini L. Testosterone 5 alpha-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axons. J. Steroid Biochem. 1988, 31:173-179.
26. Melcangi R.C., Celotti F., Martini L. Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes. Brain Res. 1994, 639:202-206.
27. Melcangi R.C., Poletti A., Cavarretta I., Celotti F., Colciago A., Magnaghi V., Motta M., Negri-Cesi P., Martini L. The 5alpha-reductase in the central nervous system: expression and modes of control. J. Steroid Biochem. Mol. Biol. 1998, 65:295-299. Review.
28. Miyamoto T., Kagawa S., Kitagawa K., Futaki S., Yokoi H., Tsuruo Y., Ishimura K. Immunocytochemical localization of 5 alpha-reductase type 1 in the prostate of normal and castrated rats. Histochem. Cell Biol. 1996, 105:101-109.
29. Mukai H., Tsurugizawa T., Ogiue-Ikeda M., Murakami G., Hojo Y., Ishii H., Kimoto T., Kawato S. Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory. Neuroendocrinology 2006, 84:255-263. Review.
30. Normington K., Russell D.W. Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. J. Biol. Chem. 1992, 267:19548-19554.
31. Nudel U., Zakut R., Shani M., Neuman S., Levy Z., Yaffe D. The nucleotide sequence of the rat cytoplasmic beta-actin gene. Nucleic Acids Res. 1983, 11:1759-1771.
32. Pelletier G., Luu-The V., Labrie F. Immunocytochemical localization of 5 alpha-reductase in rat brain. Mol. Cell. Neurosci. 1994, 5:394-399.
33. Perea G., Navarrete M., Araque A. Tripartite synapses: astrocytes process and control synaptic information. Trends Neurosci. 2009, 8:421-431. Review.
34. Piet R., Jahr C.E. Glutamatergic and purinergic receptor-mediated calcium transients in Bergmann glial cells. J. Neurosci. 2007, 27:4027-4035.
35. Poletti A., Celotti F., Rumio C., Rabuffetti M., Martini L. Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brain. Mol. Cell. Endocrinol. 1997, 129:181-190.
36. Poletti A., Negri-Cesi P., Rabuffetti M., Colciago A., Celotti F., Martini L. Transient expression of the 5alpha-reductase type 2 isozyme in the rat brain in late fetal and early postnatal life. Endocrinology 1998, 139:2171-2178.
37. Rieger A., Deitmer J.W., Lohr C. Axon-glia communication evokes calcium signaling in olfactory ensheathing cells of the developing olfactory bulb. Glia 2007, 55:352-359.
38. Russell D.W., Wilson J.D. Steroid 5 alpha-reductase: two genes/two enzymes. Annu. Rev. Biochem. 1994, 63:25-61. Review.
39. Sakamoto H., Ukena K., Tsutsui K. Effects of progesterone synthesized de novo in the developing Purkinje cell on its dendritic growth and synaptogenesis. J. Neurosci. 2001, 21:6221-6232.
40. Sakamoto H., Mezaki Y., Shikimi H., Ukena K., Tsutsui K. Dendritic growth and spine formation in response to estrogen in the developing Purkinje cell. Endocrinology 2003, 144:4466-4477.
41. Schumacher M., Hussain R., Gago N., Oudinet J.P., Mattern C., Ghoumari A.M. Progesterone synthesis in the nervous system: implications for myelination and myelin repair. Front Neurosci. 2012, 6:10.
42. Schwarz J.M., Liang S.L., Thompson S.M., McCarthy M.M. Estradiol induces hypothalamic dendritic spines by enhancing glutamate release: a mechanism for organizational sex differences. Neuron 2008, 58:584-598.
43. Toida K., Kosaka K., Heizmann C.W., Kosaka T. Electron microscopic serial-sectioning/reconstruction study of parvalbumin-containing neurons in the external plexiform layer of the rat olfactory bulb. Neuroscience 1996, 72:449-466.
44. Toida K., Kosaka K., Heizmann C.W., Kosaka T. Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb: III. Structural features of calbindin D28K-immunoreactive neurons. J. Comp. Neurol. 1998, 392:179-198.
45. Toida K., Kosaka K., Aika Y., Kosaka T. Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb--IV. Intraglomerular synapses of tyrosine hydroxylase-immunoreactive neurons. Neuroscience 2000, 101:11-17.
46. Torres J.M., Ortega E. Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain. FASEB J. 2003, 17:1428-1433.
47. Tsuruo Y., Miyamoto T., Yokoi H., Kitagawa K., Futaki S., Ishimura K. Immunohistochemical presence of 5 alpha-reductase rat type 1-containing cells in the rat brain. Brain Res. 1996, 722:207-211.
48. Tsutsui K., Sakamoto H., Ukena K. Biosynthesis and action of neurosteroids in the cerebellar Purkinje neuron. J. Steroid Biochem. Mol. Biol. 2003, 85:311-321.
49. Tsutsui K., Sakamoto H., Shikimi H., Ukena K. Organizing actions of neurosteroids in the Purkinje neuron. Neurosci. Res. 2004, 49:273-279. Review.
50. Tsutsui K., Ukena K., Sakamoto H., Okuyama S., Haraguchi S. Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell. Front. Endocrinol. (Lausanne) 2011, 2:61.
51. Ukena K., Usui M., Kohchi C., Tsutsui K. Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats. Endocrinology 1998, 139:137-147.
52. Ukena K., Kohchi C., Tsutsui K. Expression and activity of 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase in the rat Purkinje neuron during neonatal life. Endocrinology 1999, 140:805-813.
53. Yamada K., Fukaya M., Shibata T., Kurihara H., Tanaka K., Inoue Y., Watanabe M. Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth and synapse formation of cerebellar Purkinje cells. J. Comp. Neurol. 2000, 418:106-120.