The PRDX2 gene is transcriptionally silenced and de novo methylated in hodgkin and reed-sternberg cells of classical hodgkin lymphoma

Blood

Volumn 123, Issue 23, 2014, Pages 3672-3674

  Schneider, Markus ^a   Szaumkessel, Marcin ^b   Richter, Julia ^c   Ammerpohl, Ole ^c   Hansmann, Martin Leo ^d   Küppers, Ralf ^a   Siebert, Reiner ^c   Giefing, Maciej ^b,e  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b POLISH ACADEMY OF SCIENCES   (Poland)

^c UNIVERSITY OF KIEL   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OCTAMER TRANSCRIPTION FACTOR 1; PEROXIREDOXIN 2; PROTEIN; REACTIVE OXYGEN METABOLITE; TCF4 PROTEIN; TRANSCRIPTION FACTOR ELF 1; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG; HISTONE; PEROXIREDOXIN; TUMOR SUPPRESSOR PROTEIN;

ACUTE MYELOBLASTIC LEUKEMIA; BONE MARROW CELL; CANCER PROGNOSIS; CLASSICAL HODGKIN LYMPHOMA; DEACETYLATION; DNA METHYLATION; EPIGENETICS; GENE SILENCING; GERMINAL CENTER; HUMAN; LASER MICRODISSECTION; LETTER; LYMPHOBLASTOID CELL LINE; MEMORY CELL; PRIORITY JOURNAL; PROMOTER REGION; PYROSEQUENCING; REED STERNBERG CELL; FEMALE; GENETICS; MALE; METABOLISM; NOTE;

DNA METHYLATION; FEMALE; HISTONES; HUMANS; MALE; PEROXIREDOXINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84905914746     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-02-553263     Document Type: Letter

References (7)

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2. Ammerpohl O, Haake A, Pellissery S, et al. Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes. Leukemia. 2012;26(1): 185-188.
3. Küppers R, Klein U, Schwering I, et al. Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling. J Clin Invest. 2003; 111(4):529-537.
4. ENCODE Project Consortium. A user's guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biol. 2011;9(4):e1001046.
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7. Giefing M, Winoto-Morbach S, Sosna J, et al. Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacity. PLoS ONE. 2013;8(12): e84928.