Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3736-3738

  Fujimoto, Kenzo ^a   Takematsu, Yu Ki ^a   Shigeno, Atsuo ^a   Furusawa, Mirei ^a   Sakamoto, Takashi ^a  

^a JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

5 Fluorouracil; Cancer cells; Photoirradiation; Prodrug

Indexed keywords

5-IODOURACIL; ANTINEOPLASTIC AGENT; FLUOROURACIL; OLIGONUCLEOTIDE; PRODRUG; URACIL; ANTIMITOTIC AGENT; FLUOROURACIL DERIVATIVE; HYDROGEN; PHOSPHOROTHIOIC ACID DERIVATIVE; URACIL DERIVATIVE;

ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; HUMAN; PHOTOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; DRUG EFFICACY; FEMALE; HUMAN CELL; HYDROGEN BOND; LIGHT EXPOSURE; MITOSIS INHIBITION; PHOTOREACTIVITY;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES; PHOTOCHEMICAL PROCESSES; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL;

EID: 84905909868     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.002     Document Type: Article

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