-
1
-
-
0021970675
-
Radiation-therapy alone or in combination with chemotherapy in the treatment of residual or inoperable carcinoma of the rectum and rectosigmoid or pelvic recurrence following colorectal surgery - Radiation-therapy oncology group-study
-
Rominger, C.J.; Gelber, R.D.; Gunderson, L.L; Conner, N. Radiation-therapy alone or in combination with chemotherapy in the treatment of residual or inoperable carcinoma of the rectum and rectosigmoid or pelvic recurrence following colorectal surgery - Radiation-therapy oncology group-study. Am. J. Clin. Oncol. 1985, 8, 118-127.
-
(1985)
Am. J. Clin. Oncol
, vol.8
, pp. 118-127
-
-
Rominger, C.J.1
Gelber, R.D.2
Gunderson, L.L.3
Conner, N.4
-
2
-
-
0023855192
-
Postoperative adjuvant chemotherapy or BCG for colon cancer - Results from NSABP protocol-C-01
-
Wolmark, N.; Fisher, B.; Rockette, H.; Redmond, C.; Wickerham, D.L., Fisher, E.R.; Jones, J.; Glass, A.; Lerner, H.; Lawrence, W.; Prager, D.; Wexler, M.; Evans, J.; Cruz, A.; Dimitrov, N.; Jochimsen, P. Postoperative adjuvant chemotherapy or BCG for colon cancer - Results from NSABP protocol-C-01. J. Natl. Cancer Inst. 1988, 80, 30-36.
-
(1988)
J. Natl. Cancer Inst
, vol.80
, pp. 30-36
-
-
Wolmark, N.1
Fisher, B.2
Rockette, H.3
Redmond, C.4
Wickerham, D.L.5
Fisher, E.R.6
Jones, J.7
Glass, A.8
Lerner, H.9
Lawrence, W.10
Prager, D.11
Wexler, M.12
Evans, J.13
Cruz, A.14
Dimitrov, N.15
Jochimsen, P.16
-
3
-
-
0029051690
-
Thymidine phosphorylase mediates the sensitivity of human colon-carcinoma cells to 5-fluorouracil
-
Schwartz, E.L.; Baptiste, N.; Wadler, S.; Makower, D. Thymidine phosphorylase mediates the sensitivity of human colon-carcinoma cells to 5-fluorouracil. J. Biol. Chem. 1995, 270, 19073-19077.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 19073-19077
-
-
Schwartz, E.L.1
Baptiste, N.2
Wadler, S.3
Makower, D.4
-
4
-
-
0344267645
-
Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: In vitro and in vivo study
-
Evrard, A.; Cuq, P.; Robert, B.; Vian, L.; Pelegrin, A.; Cano, J.P. Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: In vitro and in vivo study. Int. J. Cancer 1999, 80, 465-470.
-
(1999)
Int. J. Cancer
, vol.80
, pp. 465-470
-
-
Evrard, A.1
Cuq, P.2
Robert, B.3
Vian, L.4
Pelegrin, A.5
Cano, J.P.6
-
5
-
-
0000875305
-
Studies on fluorinated pyrimidines. 13. Inhibition of thymidylate synthetase
-
Hartmann, K.U.; Heidelberger, C. Studies on fluorinated pyrimidines. 13. Inhibition of thymidylate synthetase. J. Biol. Chem. 1961, 236, 3006-3013.
-
(1961)
J. Biol. Chem
, vol.236
, pp. 3006-3013
-
-
Hartmann, K.U.1
Heidelberger, C.2
-
6
-
-
0029156922
-
Thymidylate synthase and drug-resistance
-
Peters, G.J.; Vanderwilt, C.L.; Vantriest, B.; Codaccipisanelli, G.; Johnston, P.G.; Vangroeningen, C.J.; Pinedo, H.M. Thymidylate synthase and drug-resistance. Eur. J. Cancer 1995, 31A, 1299-1305.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 1299-1305
-
-
Peters, G.J.1
Vanderwilt, C.L.2
Vantriest, B.3
Codaccipisanelli, G.4
Johnston, P.G.5
Vangroeningen, C.J.6
Pinedo, H.M.7
-
7
-
-
0032080712
-
High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy
-
Yeh, K.H.; Shun, C.T.; Chen, C.L.; Lin, J.T.; Lee, W.J.; Lee, P.H.; Chen, Y.C.; Cheng, A.L. High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy. Cancer 1998, 82, 1626-1631.
-
(1998)
Cancer
, vol.82
, pp. 1626-1631
-
-
Yeh, K.H.1
Shun, C.T.2
Chen, C.L.3
Lin, J.T.4
Lee, W.J.5
Lee, P.H.6
Chen, Y.C.7
Cheng, A.L.8
-
8
-
-
0001199533
-
Chemical aspects of selective toxicity
-
Albert, A. Chemical aspects of selective toxicity. Nature 1958, 182, 421-423.
-
(1958)
Nature
, vol.182
, pp. 421-423
-
-
Albert, A.1
-
9
-
-
0019276096
-
Prodrugs and site-specific drug delivery
-
Stella, V.J.; Himmelstein, K.J. Prodrugs and site-specific drug delivery. J. Med. Chem. 1980, 23, 1275-1282.
-
(1980)
J. Med. Chem
, vol.23
, pp. 1275-1282
-
-
Stella, V.J.1
Himmelstein, K.J.2
-
10
-
-
39349084237
-
Prodrug strategies in anticancer chemotherapy
-
Kratz, F.; Muller I.A.; Ryppa, C.; Warnecke, A.; Prodrug strategies in anticancer chemotherapy. ChemMedChem 2008, 3, 20-53.
-
(2008)
ChemMedChem
, vol.3
, pp. 20-53
-
-
Kratz, F.1
Muller, I.A.2
Ryppa, C.3
Warnecke, A.4
-
11
-
-
40149088986
-
Prodrugs: Design and clinical applications
-
Rautio, J.; Kumpulainen, H.; Heimbach, T.; Oliyai, R. Oh, D.; Järvinen, T.; Savolainen, J. Prodrugs: Design and clinical applications. Nat. Rev. Drug Discov. 2008, 7, 255-270.
-
(2008)
Nat. Rev. Drug Discov
, vol.7
, pp. 255-270
-
-
Rautio, J.1
Kumpulainen, H.2
Heimbach, T.3
Oliyai, R.4
Oh, D.5
Järvinen, T.6
Savolainen, J.7
-
12
-
-
1542376883
-
Enzyme-catalyzed activation of anticancer prodrugs
-
Rooseboom, M.; Commandeur, J.N.M.; Vermeulen, N.P.E. Enzyme-catalyzed activation of anticancer prodrugs. Pharmacol. Rev. 2004, 56, 53-102.
-
(2004)
Pharmacol. Rev
, vol.56
, pp. 53-102
-
-
Rooseboom, M.1
Commandeur, J.N.M.2
Vermeulen, N.P.E.3
-
13
-
-
0018179513
-
Studies on anti-tumor agents .2. Syntheses and anti-tumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5- fluorouracil
-
Yasumoto, M.; Yamawaki, I.; Marunaka, T.; Hashimoto, S. Studies on anti-tumor agents .2. Syntheses and anti-tumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5- fluorouracil. J. Med. Chem. 1978, 21, 738-741.
-
(1978)
J. Med. Chem
, vol.21
, pp. 738-741
-
-
Yasumoto, M.1
Yamawaki, I.2
Marunaka, T.3
Hashimoto, S.4
-
14
-
-
0018918947
-
Structure of two hydroxylated metabolites of ftorafur
-
Meyer, R.B.; Levenson, C.H. Structure of two hydroxylated metabolites of ftorafur. Biochem. Pharmacol. 1980, 29, 665-668.
-
(1980)
Biochem. Pharmacol
, vol.29
, pp. 665-668
-
-
Meyer, R.B.1
Levenson, C.H.2
-
15
-
-
0019477355
-
The pharmacology of ftorafur (R, S-1-(tetrahydro-2- furanyl)-5-fluorouracil)
-
Au, J.L.; Sadee, W. The pharmacology of ftorafur (R, S-1-(tetrahydro-2- furanyl)-5-fluorouracil). Recent Results Cancer Res. 1981, 76, 100-114.
-
(1981)
Recent Results Cancer Res
, vol.76
, pp. 100-114
-
-
Au, J.L.1
Sadee, W.2
-
16
-
-
0018235648
-
Anti-tumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors
-
Iigo, M.; Hoshi, A.; Nakamura, A.; Kuretani, K. Anti-tumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors. Cancer Chemother. Pharmacol. 1978, 1, 203-208.
-
(1978)
Cancer Chemother. Pharmacol
, vol.1
, pp. 203-208
-
-
Iigo, M.1
Hoshi, A.2
Nakamura, A.3
Kuretani, K.4
-
17
-
-
0025233669
-
Transdermal delivery of 5-fluorouracil and its alkylcarbamoyl derivatives
-
Sasaki, H.; Takahashi, T.; Mori, Y. Nakamura, J.; Shibasaki, J. Transdermal delivery of 5-fluorouracil and its alkylcarbamoyl derivatives. Int. J. Pharm. 1990, 60, 1-9.
-
(1990)
Int. J. Pharm
, vol.60
, pp. 1-9
-
-
Sasaki, H.1
Takahashi, T.2
Mori, Y.3
Nakamura, J.4
Shibasaki, J.5
-
18
-
-
0033770342
-
5-Fluorouracil: Forty-plus and still ticking. A review of its preclinical and clinical development
-
Grem, J.L. 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. Invest. New Drugs 2000, 18, 299-313.
-
(2000)
Invest. New Drugs
, vol.18
, pp. 299-313
-
-
Grem, J.L.1
-
19
-
-
0032006318
-
Comparison of 5-fluoro-2′-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer
-
van Laar, J.A.M.; Rustum, Y.M.; Ackland, S.P.; van Groeningen, C.J.; Peters, G.J. Comparison of 5-fluoro-2′-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer. Eur. J. Cancer 1998, 34, 296-306.
-
(1998)
Eur. J. Cancer
, vol.34
, pp. 296-306
-
-
van Laar, J.A.M.1
Rustum, Y.M.2
Ackland, S.P.3
van Groeningen, C.J.4
Peters, G.J.5
-
20
-
-
0023785929
-
Subcutaneous polymeric matrix system p(hema-bga) for controlled release of an anticancer drug (5-fluorouracil). 2. Release kinetics
-
Denizli, A.; Kiremitci, M.; Piskin, E. Subcutaneous polymeric matrix system p(hema-bga) for controlled release of an anticancer drug (5-fluorouracil). 2. Release kinetics. Biomaterials 1988, 9, 363-366.
-
(1988)
Biomaterials
, vol.9
, pp. 363-366
-
-
Denizli, A.1
Kiremitci, M.2
Piskin, E.3
-
21
-
-
0025981613
-
Controlled release of 5-fluoro-2′-deoxyuridine by the combination of prodrug and polymer matrix
-
Endoh, H.; Kawaguchi, T.; Seki, T.; Hasegawa, T.; Juni, K. Controlled release of 5-fluoro-2′-deoxyuridine by the combination of prodrug and polymer matrix. Chem. Pharm. Bull. 1991, 39, 458-464.
-
(1991)
Chem. Pharm. Bull
, vol.39
, pp. 458-464
-
-
Endoh, H.1
Kawaguchi, T.2
Seki, T.3
Hasegawa, T.4
Juni, K.5
-
22
-
-
0033321793
-
Controlled release behavior of prodrugs based on the biodegradable poly(L-glutamic acid) microspheres
-
Kim, K.S.; Kim, T.K.; Graham, N.B. Controlled release behavior of prodrugs based on the biodegradable poly(L-glutamic acid) microspheres. Polym. J. 1999, 31, 813-816.
-
(1999)
Polym. J
, vol.31
, pp. 813-816
-
-
Kim, K.S.1
Kim, T.K.2
Graham, N.B.3
-
23
-
-
18544410822
-
In vitro and in vivo characterisation of a recombinant carboxypeptidase G(2)::anti-CEA scFv fusion protein
-
Michael, N.P.; Chester, K.A.; Melton, R.G.; Robson, L.; Nicholas, W.; Boden, J.A.; Pedley, R.B.; Begent, R.H.; Sherwood, R.F.; Minton, N.P. In vitro and in vivo characterisation of a recombinant carboxypeptidase G(2)::anti-CEA scFv fusion protein. Immunotechnology 1996, 2, 47-57.
-
(1996)
Immunotechnology
, vol.2
, pp. 47-57
-
-
Michael, N.P.1
Chester, K.A.2
Melton, R.G.3
Robson, L.4
Nicholas, W.5
Boden, J.A.6
Pedley, R.B.7
Begent, R.H.8
Sherwood, R.F.9
Minton, N.P.10
-
24
-
-
35848952531
-
Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer
-
Coelho, V.; Dernedde, J.; Petrausch, U.; Panjideh, H.; Fuchs, H.; Menzel, C.; Dubel, S.; Keilholz, U.; Thiel, E.; Deckert, P.M. Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer. Int. J. Oncol. 2007, 31, 951-957.
-
(2007)
Int. J. Oncol
, vol.31
, pp. 951-957
-
-
Coelho, V.1
Dernedde, J.2
Petrausch, U.3
Panjideh, H.4
Fuchs, H.5
Menzel, C.6
Dubel, S.7
Keilholz, U.8
Thiel, E.9
Deckert, P.M.10
-
25
-
-
0000819461
-
Synthesis of self-immolative glucuronide spacers based on aminomethylcarbamate. Application to 5-fluorouracil prodrugs for antibody-directed enzyme prodrug therapy
-
Madec-Lougerstay, R.; Florent, J.C.; Monneret, C. Synthesis of self-immolative glucuronide spacers based on aminomethylcarbamate. Application to 5-fluorouracil prodrugs for antibody-directed enzyme prodrug therapy. J. Chem. Soc. Perkin Trans. 1 1999, 1369-1375.
-
(1999)
J. Chem. Soc. Perkin Trans. 1
, pp. 1369-1375
-
-
Madec-Lougerstay, R.1
Florent, J.C.2
Monneret, C.3
-
26
-
-
0031833651
-
Selective expression of carcinoembryonic antigen promoter in cancer cell lines- Targeting strategy for gene therapy in colorectal cancer
-
Fichera, A.; Michelassi, F.; Arenas, R.B. Selective expression of carcinoembryonic antigen promoter in cancer cell lines- Targeting strategy for gene therapy in colorectal cancer. Dis. Colon Rectum. 1998, 41, 747-754.
-
(1998)
Dis. Colon Rectum
, vol.41
, pp. 747-754
-
-
Fichera, A.1
Michelassi, F.2
Arenas, R.B.3
-
27
-
-
1442284594
-
Drug-induced increase of carcinoembryonic antigen expression in cancer cells
-
Aquino, A.; Formica, V.; Prete, S.P.; Correale, P.P.; Massara, M.C.; Turriziani, M.; De Vecchis, L; Bonmassar, E. Drug-induced increase of carcinoembryonic antigen expression in cancer cells. Pharmacol. Res. 2004, 49, 383-396.
-
(2004)
Pharmacol. Res
, vol.49
, pp. 383-396
-
-
Aquino, A.1
Formica, V.2
Prete, S.P.3
Correale, P.P.4
Massara, M.C.5
Turriziani, M.6
De Vecchis, L.7
Bonmassar, E.8
-
28
-
-
0031941292
-
Regional 'pro-drug' gene therapy: Intravenous administration of an adenoviral Vector expressing the E-coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma
-
Topf, N.; Worgall, S.; Hackett, N.R. Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral Vector expressing the E-coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma. Gene Ther. 1998, 5, 507-513.
-
(1998)
Gene Ther
, vol.5
, pp. 507-513
-
-
Topf, N.1
Worgall, S.2
Hackett, N.R.3
-
29
-
-
0038685423
-
Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy)
-
Denny, W.A. Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy). J. Biomed. Biotechnol. 2003, 48-70.
-
(2003)
J. Biomed. Biotechnol
, pp. 48-70
-
-
Denny, W.A.1
-
30
-
-
0035815157
-
N(1)-C(5′)-linked dimer hydrates of 5-substituted uracils produced by anodic oxidation in aqueous solution
-
Hatta, H.; Zhou, L.; Mori, M.; Teshima, S.; Nishimoto, S. N(1)-C(5′)-linked dimer hydrates of 5-substituted uracils produced by anodic oxidation in aqueous solution. J. Org. Chem. 2001, 66, 2232-2239.
-
(2001)
J. Org. Chem
, vol.66
, pp. 2232-2239
-
-
Hatta, H.1
Zhou, L.2
Mori, M.3
Teshima, S.4
Nishimoto, S.5
-
31
-
-
0026718848
-
1-(5′-Fluoro- 6′-hydroxy-5′,6′-dihydrouracil-5′-yl)-5-fluorouracil, a novel N(1)-C(5′)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions
-
Nishimoto, S.; Hatta, H.; Ueshima, H.; Kagiya, T. 1-(5′-Fluoro- 6′-hydroxy-5′,6′-dihydrouracil-5′-yl)-5-fluorouracil, a novel N(1)-C(5′)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions. J. Med. Chem. 1992, 35, 2711-2712.
-
(1992)
J. Med. Chem
, vol.35
, pp. 2711-2712
-
-
Nishimoto, S.1
Hatta, H.2
Ueshima, H.3
Kagiya, T.4
-
32
-
-
0024408986
-
Blood-flow, oxygen and nutrient supply, and metabolic microenvironment of human-tumors- A review
-
Vaupel, P.; Kallinowski, F.; Okunieff, P. Blood-flow, oxygen and nutrient supply, and metabolic microenvironment of human-tumors- A review. Cancer Res.1986, 49, 6449-6465.
-
(1986)
Cancer Res
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
34
-
-
6344282432
-
The design of drugs that target tumour hypoxia
-
Denny, W.A. The design of drugs that target tumour hypoxia. Aust. J. Chem. 2004, 57, 821-828.
-
(2004)
Aust. J. Chem
, vol.57
, pp. 821-828
-
-
Denny, W.A.1
-
35
-
-
34249930470
-
Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development
-
Bruno, R.D.; Njar, V.C.O. Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development. Bioorg. Med. Chem. 2007, 15, 5047-5060.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 5047-5060
-
-
Bruno, R.D.1
Njar, V.C.O.2
-
36
-
-
21244461192
-
Hypoxia-activated anticancer drugs
-
Denny, W.A. Hypoxia-activated anticancer drugs. Expert Opin. Ther. Pat. 2005, 15, 635-646.
-
(2005)
Expert Opin. Ther. Pat
, vol.15
, pp. 635-646
-
-
Denny, W.A.1
-
37
-
-
36148939048
-
Current molecular design of intelligent drugs and imaging probes targeting tumor-specic microenvironments
-
Tanabe, K.; Zhang, Z.; Ito, T.; Hatta, H.; Nishimoto, S. Current molecular design of intelligent drugs and imaging probes targeting tumor-specic microenvironments. Org. Biomol. Chem. 2007, 5, 3745-3757.
-
(2007)
Org. Biomol. Chem
, vol.5
, pp. 3745-3757
-
-
Tanabe, K.1
Zhang, Z.2
Ito, T.3
Hatta, H.4
Nishimoto, S.5
-
39
-
-
0034725814
-
Stereoelectronic effect on one-electron reductive release of 5-fluorouracil from 5-fluoro-1-(2′- oxocycloalkyl)uracils as a new class of radiation-activated antitumor prodrugs
-
Mori, M.; Hatta, H.; Nishimoto, S. Stereoelectronic effect on one-electron reductive release of 5-fluorouracil from 5-fluoro-1-(2′- oxocycloalkyl)uracils as a new class of radiation-activated antitumor prodrugs. J. Org. Chem. 2000, 65, 4641-4647.
-
(2000)
J. Org. Chem
, vol.65
, pp. 4641-4647
-
-
Mori, M.1
Hatta, H.2
Nishimoto, S.3
-
40
-
-
0034024791
-
A novel class of antitumor prodrug, 1-(2 ′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation
-
Shibamoto, Y.; Zhou, L.; Hatta, H.; Mori, M.; Nishimoto, S. A novel class of antitumor prodrug, 1-(2 ′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation. Jpn. J. Cancer Res. 2000, 91, 433-438.
-
(2000)
Jpn. J. Cancer Res
, vol.91
, pp. 433-438
-
-
Shibamoto, Y.1
Zhou, L.2
Hatta, H.3
Mori, M.4
Nishimoto, S.5
-
41
-
-
0035254229
-
In vivo evaluation of a novel antitumor prodrug, 1-(2 ′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation
-
Shibamoto, Y.; Zhou, L.; Hatta, H.; Mori, M.; Nishimoto, S. In vivo evaluation of a novel antitumor prodrug, 1-(2 ′-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2001, 49, 407-413.
-
(2001)
Int. J. Radiat. Oncol. Biol. Phys
, vol.49
, pp. 407-413
-
-
Shibamoto, Y.1
Zhou, L.2
Hatta, H.3
Mori, M.4
Nishimoto, S.5
-
42
-
-
0141504177
-
One-electron reduction characteristics of N(3)-substituted 5-fluorodeoxyuridines synthesized as radiation-activated prodrugs
-
Tanabe, K.; Mimasu, Y.; Eto, A.; Tachi, Y.; Sakakibara, S.; Mori, M.; Hatta. H.; Nishimoto, S. One-electron reduction characteristics of N(3)-substituted 5-fluorodeoxyuridines synthesized as radiation-activated prodrugs. Bioorg. Med. Chem. 2003, 11, 4551-4556.
-
(2003)
Bioorg. Med. Chem
, vol.11
, pp. 4551-4556
-
-
Tanabe, K.1
Mimasu, Y.2
Eto, A.3
Tachi, Y.4
Sakakibara, S.5
Mori, M.6
Hatta, H.7
Nishimoto, S.8
-
43
-
-
0036693263
-
Comparison of 5-fluorouracil and 5-fluoro-2′-deoxyuridine as an effector in radiation-activated prodrugs
-
Shibamoto, Y.; Mimasu, Y.; Tachi, Y.; Hatta. H.; Nishimoto, S. Comparison of 5-fluorouracil and 5-fluoro-2′-deoxyuridine as an effector in radiation-activated prodrugs. J. Chemother. 2002, 14, 390-396.
-
(2002)
J. Chemother
, vol.14
, pp. 390-396
-
-
Shibamoto, Y.1
Mimasu, Y.2
Tachi, Y.3
Hatta, H.4
Nishimoto, S.5
-
44
-
-
0942289880
-
In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2′- deoxyuridine activated by hypoxic irradiation
-
Shibamoto, Y.; Tachi, Y.; Tanabe, K.; Hatta, H.; Nishimoto, S. In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2′- deoxyuridine activated by hypoxic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2004, 58, 397-402.
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys
, vol.58
, pp. 397-402
-
-
Shibamoto, Y.1
Tachi, Y.2
Tanabe, K.3
Hatta, H.4
Nishimoto, S.5
-
45
-
-
17144361816
-
Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: Radiolytic reduction and cytotoxicity characteristics
-
Tanabe, K.; Makimura, Y.; Tachi, Y. Imagawa-Sato, A.; Nishimoto, S. Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: Radiolytic reduction and cytotoxicity characteristics. Bioorg. Med. Chem. Lett. 2005, 15, 2321-2324.
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 2321-2324
-
-
Tanabe, K.1
Makimura, Y.2
Tachi, Y.3
Imagawa-Sato, A.4
Nishimoto, S.5
-
46
-
-
15144357021
-
Indolequinone antitumor agents: Reductive activation and elimination from (5-methoxy-1-methyl- 4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro
-
Naylor, M. A.; Swann, E.; Everett, S. A.; Jaffar, M.; Nolan, J.; Robertson, N.; Lockyer, S. D.; Patel, K. B.; Dennis, M. F.; Stratford, M. R. L.; Wardman, P.; Adams, G. E.; Moody, C. J.; Stratford, I. J. Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl- 4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro. J. Med. Chem. 1998, 41, 2720-2731.
-
(1998)
J. Med. Chem
, vol.41
, pp. 2720-2731
-
-
Naylor, M.A.1
Swann, E.2
Everett, S.A.3
Jaffar, M.4
Nolan, J.5
Robertson, N.6
Lockyer, S.D.7
Patel, K.B.8
Dennis, M.F.9
Stratford, M.R.L.10
Wardman, P.11
Adams, G.E.12
Moody, C.J.13
Stratford, I.J.14
-
47
-
-
0035959970
-
Indolequinone antitumor agents: Correlation between quinine structure and rate of metabolism by recombinant human NAD(P)H: quinine oxidoreductase. Part 2
-
Swann, E.; Barraja, P.; Oberlander, A. M.; Gardipee, W. T.; Hudnott, A. R.; Beall, H. D.; Moody, C. J. Indolequinone antitumor agents: correlation between quinine structure and rate of metabolism by recombinant human NAD(P)H: quinine oxidoreductase. Part 2. J. Med. Chem. 2001, 44, 3311-3319.
-
(2001)
J. Med. Chem
, vol.44
, pp. 3311-3319
-
-
Swann, E.1
Barraja, P.2
Oberlander, A.M.3
Gardipee, W.T.4
Hudnott, A.R.5
Beall, H.D.6
Moody, C.J.7
-
48
-
-
0036682238
-
Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase
-
Hernick, M.; Flader, C.; Borch, R. F. Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase. J. Med. Chem. 2002, 45, 3540-3548.
-
(2002)
J. Med. Chem
, vol.45
, pp. 3540-3548
-
-
Hernick, M.1
Flader, C.2
Borch, R.F.3
-
49
-
-
0036569920
-
Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: A key factor in controlling hypoxia-selective drug release
-
Everett, S. A.; Swann, E.; Naylor, M. A.; Stratford, M. R. L.; Patel, K. B.; Tian, A.; Newman, R. G.; Vojnovic, B.; Moody, C. J.; Wardman, P. Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: A key factor in controlling hypoxia-selective drug release. Biochem. Pharmacol. 2002, 63, 1629-1639.
-
(2002)
Biochem. Pharmacol
, vol.63
, pp. 1629-1639
-
-
Everett, S.A.1
Swann, E.2
Naylor, M.A.3
Stratford, M.R.L.4
Patel, K.B.5
Tian, A.6
Newman, R.G.7
Vojnovic, B.8
Moody, C.J.9
Wardman, P.10
-
50
-
-
0034848005
-
Recognition and cleavage at the DNA major groove
-
Skibo, E. B.; Xing, C.; Groy, T. Recognition and cleavage at the DNA major groove. Bioorg. Med. Chem. 2001, 9, 2445-2459.
-
(2001)
Bioorg. Med. Chem
, vol.9
, pp. 2445-2459
-
-
Skibo, E.B.1
Xing, C.2
Groy, T.3
-
51
-
-
0033951038
-
Using photolabile ligands in drug discovery and development
-
Dormán, G.; Prestwich, G.D. Using photolabile ligands in drug discovery and development. Trends Biotech. 2000, 18, 64-77.
-
(2000)
Trends Biotech
, vol.18
, pp. 64-77
-
-
Dormán, G.1
Prestwich, G.D.2
-
52
-
-
0032540405
-
Nitrobenzyl-based photosensitive phosphoramide mustards: Synthesis and photochemical properties of potential prodrugs for cancer therapy
-
Reinhard, R.; Schmidt, B.F. Nitrobenzyl-based photosensitive phosphoramide mustards: Synthesis and photochemical properties of potential prodrugs for cancer therapy. J. Org. Chem. 1998, 63, 2434-2441.
-
(1998)
J. Org. Chem
, vol.63
, pp. 2434-2441
-
-
Reinhard, R.1
Schmidt, B.F.2
-
53
-
-
0034694705
-
New dendritic caged compounds: Synthesis, mass spectrometric characterization, and photochemical properties of dentrimers with a-carboxy-2-nitrobenzyl caged compounds at their periphery
-
Watanabe, S.; Sato, M.; Sakamoto, S.; Yamaguchi, K.; Iwamura, M. New dendritic caged compounds: synthesis, mass spectrometric characterization, and photochemical properties of dentrimers with a-carboxy-2-nitrobenzyl caged compounds at their periphery. J. Am. Chem. Soc. 2000, 122, 12588-12589.
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 12588-12589
-
-
Watanabe, S.1
Sato, M.2
Sakamoto, S.3
Yamaguchi, K.4
Iwamura, M.5
-
54
-
-
0036152653
-
Design, synthesis, photochemical properties and cytotoxic activities of water-soluble caged Lleucyl-L-leucine methyl esters that control apoptosis of immune cells
-
Mizuta, H.; Watanabe, S.; Sakurai, Y.; Nishiyama, K.; Furuta, T.; Kobayashi, Y.; Iwamura, M. Design, synthesis, photochemical properties and cytotoxic activities of water-soluble caged Lleucyl-L-leucine methyl esters that control apoptosis of immune cells. Bioorg. Med. Chem. 2002, 10, 675-683.
-
(2002)
Bioorg. Med. Chem
, vol.10
, pp. 675-683
-
-
Mizuta, H.1
Watanabe, S.2
Sakurai, Y.3
Nishiyama, K.4
Furuta, T.5
Kobayashi, Y.6
Iwamura, M.7
-
55
-
-
34547776440
-
Light-triggered molecule-scale drug dosing devices
-
McCoy, C.P.; Rooney, C.; Edwards, C.R.; Jones, D.S.; Gorman, S.P. Light-triggered molecule-scale drug dosing devices. J. Am. Chem. Soc. 2007, 129, 9572-9573.
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 9572-9573
-
-
McCoy, C.P.1
Rooney, C.2
Edwards, C.R.3
Jones, D.S.4
Gorman, S.P.5
-
56
-
-
33845434621
-
Rational design of a dual-mode optical and chemical prodrug
-
McCoy, C.P.; Rooney, C.; Jones, D. S.; Gorman, S.P.; Nieuwenhuyzen, M. Rational design of a dual-mode optical and chemical prodrug. Pharm. Res. 2007, 24, 194-200.
-
(2007)
Pharm. Res
, vol.24
, pp. 194-200
-
-
McCoy, C.P.1
Rooney, C.2
Jones, D.S.3
Gorman, S.P.4
Nieuwenhuyzen, M.5
-
57
-
-
33644969545
-
Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation
-
Tachi, Y.; Dai, W.-M.; Tanabe, K.; Nishimoto, S. Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation. Bioorg. Med. Chem. 2006, 14, 3199-3209.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 3199-3209
-
-
Tachi, Y.1
Dai, W.-M.2
Tanabe, K.3
Nishimoto, S.4
-
58
-
-
33746222883
-
Development of first photoresponsive prodrug of paclitaxel
-
Skwarczynski, M.; Noguchi, M.; Hirota, S.; Sohma, Y.; Kimura, T.; Hayashi, Y.; Kiso, Y. Development of first photoresponsive prodrug of paclitaxel. Bioorg. Med. Chem. Lett. 2006, 16, 4492-4496.
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 4492-4496
-
-
Skwarczynski, M.1
Noguchi, M.2
Hirota, S.3
Sohma, Y.4
Kimura, T.5
Hayashi, Y.6
Kiso, Y.7
-
59
-
-
43749100667
-
Development of novel water-soluble photocleavable protecting group and its application for design of photoresponsive paclitaxel prodrugs
-
Noguchi, M.; Skwarczynski, M.; Prakash, H.; Hirota, S.; Kimura, T.; Hayashi, Y.; Kiso, Y. Development of novel water-soluble photocleavable protecting group and its application for design of photoresponsive paclitaxel prodrugs. Bioorg. Med. Chem. 2008, 16, 5389-5397.
-
(2008)
Bioorg. Med. Chem
, vol.16
, pp. 5389-5397
-
-
Noguchi, M.1
Skwarczynski, M.2
Prakash, H.3
Hirota, S.4
Kimura, T.5
Hayashi, Y.6
Kiso, Y.7
-
60
-
-
0003391871
-
-
Morrison, H, Ed; John Wiley & Sons, Inc: New York, USA
-
Willner, I.; Willner, B. Biological Applications of Photochemical Switches; Morrison, H., Ed; John Wiley & Sons, Inc: New York, USA, 1993.
-
(1993)
Biological Applications of Photochemical Switches
-
-
Willner, I.1
Willner, B.2
-
61
-
-
17044442290
-
A photoactivated prodrug
-
Wei, Y.; Yan, Y.; Pei, D.; Gong, B. A photoactivated prodrug. Bioorg. Med. Chem. Lett. 1998, 8, 2419-2422.
-
(1998)
Bioorg. Med. Chem. Lett
, vol.8
, pp. 2419-2422
-
-
Wei, Y.1
Yan, Y.2
Pei, D.3
Gong, B.4
-
62
-
-
14544287702
-
Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil
-
Zhang, Z.; Hatta, H.; Ito, T.; Nishimoto, S. Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil. Org. Biomol. Chem. 2005, 3, 592-596.
-
(2005)
Org. Biomol. Chem
, vol.3
, pp. 592-596
-
-
Zhang, Z.1
Hatta, H.2
Ito, T.3
Nishimoto, S.4
-
63
-
-
53649105098
-
A model for light-triggered porphyrin anticancer prodrugs based on an o-nitrobenzyl photolabile group
-
Lin, W.; Peng, D.; Wang, B.; Long, L.; Guo, C.; Yuan, J. A model for light-triggered porphyrin anticancer prodrugs based on an o-nitrobenzyl photolabile group. Eur. J. Org. Chem. 2008, 793-796.
-
(2008)
Eur. J. Org. Chem
, pp. 793-796
-
-
Lin, W.1
Peng, D.2
Wang, B.3
Long, L.4
Guo, C.5
Yuan, J.6
-
64
-
-
0031879628
-
Uracil-tegafur in gastric carcinoma: A comprehensive review
-
Takiuchi, H.; Ajani, J. A. Uracil-tegafur in gastric carcinoma: a comprehensive review. J. Clin. Oncol. 1998, 16, 2877-2885.
-
(1998)
J. Clin. Oncol
, vol.16
, pp. 2877-2885
-
-
Takiuchi, H.1
Ajani, J.A.2
-
65
-
-
45849101264
-
Synthesis, characterization, and properties evaluation of methylcoumarin end-functionalized poly(methyl methacrylate) for photoinduced drug release
-
Sinkel, C.; Greiner, A.; Agarwal, S. Synthesis, characterization, and properties evaluation of methylcoumarin end-functionalized poly(methyl methacrylate) for photoinduced drug release. Macromolecules 2008, 41, 3460-3467.
-
(2008)
Macromolecules
, vol.41
, pp. 3460-3467
-
-
Sinkel, C.1
Greiner, A.2
Agarwal, S.3
|