Location, location, location! the reality of life for an intestinal stem cell in the crypt

Journal of Pathology

Volumn 234, Issue 1, 2014, Pages 1-4

  Walther, Viola ^a   Graham, Trevor A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

homeostasis; intestinal stem cells; intravital imaging; Lgr5; neutral drift; stem cell plasticity

Indexed keywords

DIPHTHERIA TOXIN;

CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL POPULATION; CRYPT CELL; IN VIVO STUDY; INTESTINAL STEM CELL; NONHUMAN; PANETH CELL; PLASTICITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; STEM CELL; STEM CELL NICHE; ANIMAL; CYTOLOGY; INTESTINE MUCOSA; MOUSE; PHYSIOLOGY;

ANIMALS; CELL DIFFERENTIATION; INTESTINAL MUCOSA; MICE; PANETH CELLS; STEM CELLS;

EID: 84905869551     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4370     Document Type: Review

References (15)

1. Barker N, van Es JH, Kuipers J, et al., Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449: 1003-1007.
2. van der Flier LG, Clevers H,. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 2009; 71: 241-260.
3. Barker N, Ridgway RA, van Es JH, et al., Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009; 457: 608-611.
4. Clevers H., The intestinal crypt, a prototype stem cell compartment. Cell 2013; 154: 274-284.
5. Sangiorgi E, Capecchi MR,. Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 2008; 40: 915-920.
6. Montgomery RK, Carlone DL, Richmond CA, et al., Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci USA 2011; 108: 179-184.
7. Westphalen CB, Asfaha S, Hayakawa Y, et al., Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest 2014; 124: 1283-1295.
8. Snippert HJ, van der Flier LG, Sato T, et al., Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 2010; 143: 134-144.
9. Tian H, Biehs B, Warming S, et al., A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 2011; 478: 255-259.
10. Zhu Y, Huang YF, Kek C, et al., Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations. Cell Stem Cell 2013; 12: 298-303.
11. Lopez-Garcia C, Klein AM, Simons BD, et al., Intestinal stem cell replacement follows a pattern of neutral drift. Science 2010; 330: 822-825.
12. Ritsma L, Ellenbroek SIJ, Zomer A, et al., Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature 2014; 507: 362-365.
13. Kozar S, Morrissey E, Nicholson AM, et al. Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell 2013; 13: 626-633.
14. Sato T, van Es JH, Snippert HJ, et al., Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 2011; 469: 415-418.
15. Potten CS, Schofield R, Lajtha LG,. A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium. Biochim Biophys Acta 1979; 560: 281-299.