Defunctioning polymorphism in the immunoglobulin G inhibitory receptor (FcγRIIB-T/T232) does not impact on kidney transplant or recipient survival

Transplantation

Volumn 98, Issue 3, 2014, Pages 285-291

  Clatworthy, Menna R ^a   Matthews, Rebeccah J ^a   Doehler, Bernd ^b   Willcocks, Lisa C ^a   Opelz, Gerhard ^b   Smith, Kenneth G C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Antibodies; CD32B; Chronic antibody mediated rejection.; FcF receptors; FcFRIIB; IgG; Renal transplantation

Indexed keywords

CREATININE; FC RECEPTOR IIB; PANEL REACTIVE ANTIBODY;

ACUTE GRAFT REJECTION; ADOLESCENT; ADULT; AFRICAN CARIBBEAN; AGED; ARTICLE; CAUCASIAN; CHILD; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; GRAFT SURVIVAL; HETEROZYGOTE; HOMOZYGOTE; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; GRAFT SURVIVAL; HUMANS; KIDNEY TRANSPLANTATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, IGG; TRANSPLANTATION, HOMOLOGOUS;

EID: 84905868566     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000287     Document Type: Article

References (28)

1. Stegall MD, Raghavaiah S, Gloor JM. The (re)emergence of B cells in organ transplantation. Curr Opin Organ Transplant 2010; 15: 451.
2. Loupy A, Hill GS, Jordan SC. The impact of donor-specific anti-HLA antibodies on late kidney allograft failure. Nat Rev Nephrol 2012; 8: 348.
3. Bentall A, Cornell LD, Gloor JM, et al. Five-year outcomes in living donor kidney transplants with a positive crossmatch. Am J Transplant 2013; 13: 76.
4. Nimmerjahn F, Ravetch JV. Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 2008; 8: 34.
5. Titus JA, Perez P, Kaubisch A, et al. Human K/natural killer cells targeted with hetero-cross-linked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo. J Immunol 1987; 139: 3153.
6. Metes D, Ernst LK, Chambers WH, et al. Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. Blood 1998; 91: 2369.
7. Smith KGC, Clatworthy MR. FcgammaRIIB in autoimmunity and infection: Evolutionary and therapeutic implications. Nat Rev Immunol 2010; 10: 328.
8. Baerenwaldt A, Lux A, Danzer H, et al. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci USA 2011; 108: 18772.
9. Xiang Z, Cutler AJ, Brownlie RJ, et al. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol 2007; 8: 419.
10. Takai T, Ono M, Hikida M, et al. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 1996; 379: 346.
11. Bolland S, Ravetch JV. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. Immunity 2000; 13: 277.
12. Clynes RA, Towers TL, Presta LG, et al. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 2000; 6: 443.
13. Clatworthy MR, Smith KG. FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med 2004; 199: 717.
14. ClatworthyMR,Willcocks L,Urban B, et al. Systemic lupus erythematosusassociated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria. Proc Natl Acad Sci USA 2007; 104: 7169.
15. Callaghan CJ, Win TS, Motallebzadeh R, et al. Regulation of allograft survival by inhibitory FcgammaRIIb signaling. J Immunol 2012; 189: 5694.
16. Floto RA, Clatworthy MR, Heilbronn KR, et al. Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts. Nat Med 2005; 11: 1056.
17. Kono H, Kyogoku C, Suzuki T, et al. FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum Mol Genet 2005; 14: 2881.
18. Willcocks LC, Carr EJ, Niederer HA, et al. A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. Proc Natl Acad Sci USA 2010; 107: 7881.
19. Li X, Wu J, Carter RH, et al. A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling. Arthritis Rheum 2003; 48: 3242.
20. Haas M. Pathology of C4d-negative antibody-mediated rejection in renal allografts. Curr Opin Organ Transplant 2013; 18: 319.
21. Sellares J, Reeve J, Loupy A, et al. Molecular diagnosis of antibodymediated rejection in human kidney transplants. Am J Transplant 2013; 13: 971.
22. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 2008; 8: 753.
23. Hidalgo LG, Sis B, Sellares J, et al. NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: Evidence for NK cell involvement in antibody-mediated rejection. Am J Transplant 2010; 10: 1812.
24. Hirohashi T, Chase CM, Della Pelle P, et al. A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant 2012; 12: 313.
25. Randhawa PS, Schonder K, Shapiro R, et al. Polyomavirus BK neutralizing activity in human immunoglobulin preparations. Transplantation 2010; 89: 1462.
26. Gjertsson I, Kleinau S, Tarkowski A. The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog 2002; 33: 145.
27. Maglione PJ, Xu J, Casadevall A, et al. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. J Immunol 2008; 180: 3329.
28. Da Silva DM, Fausch SC, Verbeek JS, et al. Uptake of human papillomavirus virus-like particles by dendritic cells is mediated by Fcgamma receptors and contributes to acquisition of T cell immunity. J Immunol 2007; 178: 7587.