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Volumn 18, Issue 2, 2014, Pages 100-106

Pharmaceutical innovation: Impact on expenditure and outcomes and subsequent challenges for pharmaceutical policy, with a special reference to Greece

Author keywords

Drug costs; Greece; Innovation diffusion; Pharmaceutical economics; Pharmaceutical technology

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTACID AGENT; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ANTIMIGRAINE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HISTAMINE H2 RECEPTOR ANTAGONIST; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INFLUENZA VACCINE; NEUROLEPTIC AGENT; PROTON PUMP INHIBITOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SEROTONIN UPTAKE INHIBITOR;

EID: 84905700332     PISSN: 11084189     EISSN: 17908019     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (59)
  • 1
    • 70149116516 scopus 로고    scopus 로고
    • The role of health technology assessment in the European Union, European Observatory on Health Systems and Policies, Copenhagen
    • Sorenson C, Drummond M, Kanavos P. Ensuring value for money in health care. The role of health technology assessment in the European Union, European Observatory on Health Systems and Policies, Copenhagen, 2008, 3-4.
    • (2008) Ensuring value for money in health care. , pp. 3-4
    • Sorenson, C.1    Drummond, M.2    Kanavos, P.3
  • 2
    • 84875997218 scopus 로고    scopus 로고
    • Topfer L, Chan L(eds), INAHTA Secretariat, Cologne, DE. Available from: last accessed 2012 Nov1
    • Facey K. INAHTA Health Technology Assessment (HTA) Glossary [Internet]. Topfer L, Chan L(eds), INAHTA Secretariat, Cologne, DE, 2006. Available from: http://www.inahta.net/Glossary/, last accessed 2012 Nov 1.
    • (2006) INAHTA Health Technology Assessment (HTA) Glossary [Internet].
    • Facey, K.1
  • 4
    • 84866785839 scopus 로고    scopus 로고
    • Health Care Financing Administration, Centers for Medicare and Medicaid Services, Baltimore, MD. Available from: last accessed 2012 Feb21
    • Smith S, Heffler SK, Freeland MS. The Impact of Technological Change on Health Care Cost Spending: An Evaluation of the Literature [Internet], Health Care Financing Administration, Centers for Medicare and Medicaid Services, Baltimore, MD,2000. Available from: http://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/NationalHealthExpendData/downloads/tech_2000_0810.pdf, last accessed 2012 Feb 21.
    • (2000) The Impact of Technological Change on Health Care Cost Spending: An Evaluation of the Literature [Internet]
    • Smith, S.1    Heffler, S.K.2    Freeland, M.S.3
  • 6
    • 84893776079 scopus 로고    scopus 로고
    • Diffusion of health technologies: Evidence from the pharmaceutical sector
    • Joan C-F, Courbage C, McGuire A (eds), Oxford University Press, New York
    • Serra-Sastre V, McGuire A, Diffusion of health technologies: evidence from the pharmaceutical sector. Joan C-F, Courbage C, McGuire A (eds), The Economics of New Technologies: incentives, organization, and financing, Oxford University Press, New York, 2009, 53-74.
    • (2009) The Economics of New Technologies: Incentives, organization, and financing , pp. 53-74
    • Serra-Sastre, V.1    McGuire, A.2
  • 7
    • 33746536484 scopus 로고    scopus 로고
    • Charles River Associates, A study undertaken for the European Commission [Internet], European Commission, Directorate General Health & Consumers, Brussels. Available from: last accessed 2014 Jan14
    • Charles River Associates, Innovation in the pharmaceutical sector. A study undertaken for the European Commission [Internet], European Commission, Directorate General Health & Consumers, Brussels, 2004. Available from: http://ec.europa.eu/health/ files/pharmacos/docs/doc2004/nov/eu_pharma_innovation_25-11-04_en.pdf, last accessed 2014 Jan 14.
    • (2004) Innovation in the pharmaceutical sector.
  • 8
    • 44449097177 scopus 로고    scopus 로고
    • Toward a definition of pharmaceutical innovation
    • Morgan S, Lopert R, Greyson D. Toward a definition of pharmaceutical innovation. Open Med. 2008; 2: e4-e7.
    • (2008) Open Med. , vol.2
    • Morgan, S.1    Lopert, R.2    Greyson, D.3
  • 9
    • 33749987748 scopus 로고    scopus 로고
    • An update on the first decade of the European centralized procedure: How many innovative drugs?
    • Motola D, De Ponti F, Poluzzi E, Martini N, Rossi P, Silvani MC, et al. An update on the first decade of the European centralized procedure: how many innovative drugs? Br J ClinPharmacol. 2006; 62: 610-616.
    • (2006) Br J ClinPharmacol. , vol.62 , pp. 610-616
    • Motola, D.1    De Ponti, F.2    Poluzzi, E.3    Martini, N.4    Rossi, P.5    Silvani, M.C.6
  • 11
    • 84886602602 scopus 로고    scopus 로고
    • OECD, Organisation for Economic Co-operation and Development, Paris. Available from: last accessed 2013 Jun30
    • OECD, Health spending continues to stagnate, says OECD [Internet], Organisation for Economic Co-operation and Development, Paris, 2013. Available from: http://www.oecd.org/ els/health-systems/health-spending-continues-to-stagnate-saysoecd.htm, last accessed 2013 Jun 30.
    • (2013) Health spending continues to stagnate, says OECD [Internet]
  • 12
    • 84877967115 scopus 로고    scopus 로고
    • The slowdown in health care spending in 2009-11 reflected factors other than the weak economy and thus may persist
    • Ryu AJ, Gibson TB, McKellar MR, Chernew ME. The slowdown in health care spending in 2009-11 reflected factors other than the weak economy and thus may persist. Health Aff (Millwood). 2013; 32: 835-840.
    • (2013) Health Aff (Millwood). , vol.32 , pp. 835-840
    • Ryu, A.J.1    Gibson, T.B.2    McKellar, M.R.3    Chernew, M.E.4
  • 13
    • 84890898549 scopus 로고    scopus 로고
    • Kaiser Family Foundation. Kaiser Family Foundation, Menlo Park, CA. Available from: last accessed 2013 Aug31
    • Kaiser Family Foundation. Assessing the Effects of the Economy on the Recent Slowdown in Health Spending [Internet], Kaiser Family Foundation, Menlo Park, CA, 2013. Available from: http://kff.org/health-costs/issue-brief/assessing-the-effects-ofthe-economy-on-the-recent-slowdown-in-health-spending-2/, last accessed 2013 Aug 31.
    • (2013) Assessing the Effects of the Economy on the Recent Slowdown in Health Spending [Internet]
  • 16
    • 0036906005 scopus 로고    scopus 로고
    • New approaches to analysing prescription data and to transfer pharmacoepidemiological and evidencebased reports to prescribers
    • Addis A, Magrini N. New approaches to analysing prescription data and to transfer pharmacoepidemiological and evidencebased reports to prescribers. Pharmacoepidemiol Drug Saf. 2002; 11: 721-726.
    • (2002) Pharmacoepidemiol Drug Saf. , vol.11 , pp. 721-726
    • Addis, A.1    Magrini, N.2
  • 17
    • 0442276037 scopus 로고    scopus 로고
    • Why did drug spending increase during the 1990s? A decomposition based on Swedish data
    • Gerdtham UG, Lundin D. Why did drug spending increase during the 1990s? A decomposition based on Swedish data. Pharmacoeconomics. 2004; 22: 29-42.
    • (2004) Pharmacoeconomics. , vol.22 , pp. 29-42
    • Gerdtham, U.G.1    Lundin, D.2
  • 18
    • 41549105383 scopus 로고    scopus 로고
    • Adoption of pharmaceutical innovation and the growth of drug expenditure in Taiwan: Is it cost effective?
    • Hsieh CR, Sloan FA. Adoption of pharmaceutical innovation and the growth of drug expenditure in Taiwan: is it cost effective? Value Health. 2008; 11: 334-344.
    • (2008) Value Health. , vol.11 , pp. 334-344
    • Hsieh, C.R.1    Sloan, F.A.2
  • 19
    • 84877139545 scopus 로고    scopus 로고
    • Increasing Anti-Infective Drug Expenditure in Tianjin, China: A Decomposition Analysis
    • Wu J, Yue N, Xu W. Increasing Anti-Infective Drug Expenditure in Tianjin, China: A Decomposition Analysis. Value Health Regional Issues. 2013; 2:37-42.
    • (2013) Value Health Regional Issues. , vol.2 , pp. 37-42
    • Wu, J.1    Yue, N.2    Xu, W.3
  • 20
    • 79958000078 scopus 로고    scopus 로고
    • The impotence of price controls: Failed attempts to constrain pharmaceutical expenditures in Greece
    • Lambrelli D, O'Donnell O. The impotence of price controls: failed attempts to constrain pharmaceutical expenditures in Greece. Health Policy. 2011; 101: 162-171.
    • (2011) Health Policy. , vol.101 , pp. 162-171
    • Lambrelli, D.1    O'Donnell, O.2
  • 21
    • 84881662216 scopus 로고    scopus 로고
    • Determination of the main factors contributing to increases in medicine expenditures for the National Health Insurance Fund in Sudan
    • Mousnad MA, Shafie AA, Mohamed Ibrahim MI. Determination of the main factors contributing to increases in medicine expenditures for the National Health Insurance Fund in Sudan. J Pharm HealthServ Res. 2013; 4: 159-164.
    • (2013) J Pharm HealthServ Res. , vol.4 , pp. 159-164
    • Mousnad, M.A.1    Shafie, A.A.2    Mohamed Ibrahim, M.I.3
  • 23
    • 26644450484 scopus 로고    scopus 로고
    • Booming prescription drug expenditure: Apopulation-based analysis of age dynamics
    • Morgan SG. Booming prescription drug expenditure: apopulation-based analysis of age dynamics. Med Care. 2005; 43: 996-1008.
    • (2005) Med Care. , vol.43 , pp. 996-1008
    • Morgan, S.G.1
  • 24
    • 1542435142 scopus 로고    scopus 로고
    • Does the aging of the population really drive the demand for health care?
    • Reinhardt UE. Does the aging of the population really drive the demand for health care? Health Aff (Millwood). 2003; 22: 27-39.
    • (2003) Health Aff (Millwood). , vol.22 , pp. 27-39
    • Reinhardt, U.E.1
  • 26
    • 72249118219 scopus 로고    scopus 로고
    • University of British Columbia, Centre for Health Services and Policy Research, Vancouver, BC. Available from: last accessed 2013 Mar3
    • Morgan SG, The determinants of prescription drug expenditure. and what to do about them [Internet], University of British Columbia, Centre for Health Services and Policy Research, Vancouver, BC, 2008. Available from: http://amcp.org/WorkArea/ DownloadAsset.aspx?id=13234, last accessed 2013 Mar 3.
    • (2008) The determinants of prescription drug expenditure. and what to do about them [Internet]
    • Morgan, S.G.1
  • 27
    • 34447547883 scopus 로고    scopus 로고
    • Lipid-lowering drugs: Use and expenditure in Portugal (1995-2004)
    • Teixeira IJ, Escoval A, Schiappa M. Lipid-lowering drugs: use and expenditure in Portugal (1995-2004). Rev Port Cardiol. 2007; 26: 475-493.
    • (2007) Rev Port Cardiol. , vol.26 , pp. 475-493
    • Teixeira, I.J.1    Escoval, A.2    Schiappa, M.3
  • 28
    • 67651159373 scopus 로고    scopus 로고
    • Canadian Cardiovascular Outcomes Research Team. Longterm trends in use of and expenditures for cardiovascular medications in Canada
    • Jackevicius CA, Cox JL, Carreon D, Tu JV, Rinfret S, So D, et al. Canadian Cardiovascular Outcomes Research Team. Longterm trends in use of and expenditures for cardiovascular medications in Canada. CMAJ. 2009; 181: E19-E28.
    • (2009) CMAJ. , vol.181
    • Jackevicius, C.A.1    Cox, J.L.2    Carreon, D.3    Tu, J.V.4    Rinfret, S.5    So, D.6
  • 30
    • 0041632158 scopus 로고    scopus 로고
    • Health Insurance and the Growth in Pharmaceutical Expenditures
    • Danzon PM, Pauly MV. Health Insurance and the Growth in Pharmaceutical Expenditures. J Law Econ. 2002; 45: 587-613.
    • (2002) J Law Econ. , vol.45 , pp. 587-613
    • Danzon, P.M.1    Pauly, M.V.2
  • 32
    • 0344646776 scopus 로고    scopus 로고
    • Is technological change in medicine worth it?
    • Cutler DM, McClellan M. Is technological change in medicine worth it? Health Aff (Millwood). 2001; 20: 11-29.
    • (2001) Health Aff (Millwood). , vol.20 , pp. 11-29
    • Cutler, D.M.1    McClellan, M.2
  • 33
    • 30744464772 scopus 로고    scopus 로고
    • Productivity Commission (AU), Commonwealth of Australia, Melbourne. Available from: last accessed 2013 Feb10
    • Productivity Commission (AU), Impacts of Advances in Medical Technology in Australia [Internet], Commonwealth of Australia, Melbourne, 2005. Available from: http://www.pc.gov. au/__data/assets/pdf_file/0003/17193/medicaltechnology.pdf, last accessed 2013 Feb 10.
    • (2005) Impacts of Advances in Medical Technology in Australia [Internet]
  • 34
    • 79956088426 scopus 로고    scopus 로고
    • National and International Tests of the New Drug Cost Offset Theory
    • Santerre RE. National and International Tests of the New Drug Cost Offset Theory. South Econ J. 2011; 77: 1033-1043.
    • (2011) South Econ J. , vol.77 , pp. 1033-1043
    • Santerre, R.E.1
  • 35
    • 0442277183 scopus 로고    scopus 로고
    • Are the benefits of newer drugs worth their cost? Evidence from the 1996 MEPS
    • Lichtenberg FR. Are the benefits of newer drugs worth their cost? Evidence from the 1996 MEPS. Health Aff (Millwood). 2001; 20: 241-251.
    • (2001) Health Aff (Millwood). , vol.20 , pp. 241-251
    • Lichtenberg, F.R.1
  • 36
    • 0347880462 scopus 로고    scopus 로고
    • National Bureau of Economic Research, Cambridge, MA. Available from: last accessed 2013 Feb10
    • Lichtenberg FR. Benefits and costs of new drugs: an update, National Bureau of Economic Research, Cambridge, MA, 2002. Available from: http://www.nber.org/papers/w8996, last accessed 2013 Feb 10.
    • (2002) Benefits and costs of new drugs: An update
    • Lichtenberg, F.R.1
  • 37
    • 34248539393 scopus 로고    scopus 로고
    • Do newer prescription drugs pay for themselves? A reassessment of the evidence
    • Zhang Y, Soumerai SB. Do newer prescription drugs pay for themselves? A reassessment of the evidence. Health Aff (Millwood). 2007; 26: 880-886.
    • (2007) Health Aff (Millwood). , vol.26 , pp. 880-886
    • Zhang, Y.1    Soumerai, S.B.2
  • 38
    • 77951719204 scopus 로고    scopus 로고
    • The effect of newer drugs on health spending: Do they really increase the costs?
    • Civan A, Köksal B. The effect of newer drugs on health spending: do they really increase the costs? Health Econ. 2010; 19:581-595.
    • (2010) Health Econ. , vol.19 , pp. 581-595
    • Civan, A.1    Köksal, B.2
  • 40
    • 0035869519 scopus 로고    scopus 로고
    • HIV Cost and Services Utilization Study Consortium. Expenditures for the care of HIV-infected patients in the era of highly active antiretroviral therapy
    • Bozzette SA, Joyce G, McCaffrey DF, Leibowitz AA, Morton SC, Berry SH, et al. HIV Cost and Services Utilization Study Consortium. Expenditures for the care of HIV-infected patients in the era of highly active antiretroviral therapy. N Engl J Med. 2001; 344: 817-823.
    • (2001) N Engl J Med. , vol.344 , pp. 817-823
    • Bozzette, S.A.1    Joyce, G.2    McCaffrey, D.F.3    Leibowitz, A.A.4    Morton, S.C.5    Berry, S.H.6
  • 41
    • 84855983919 scopus 로고    scopus 로고
    • New drugs and the growth of health expenditure: Evidence from diabetic patients in Taiwan
    • Liu YM, Hsieh CR. New drugs and the growth of health expenditure: evidence from diabetic patients in Taiwan. Health Econ. 2012; 21: 496-513.
    • (2012) Health Econ. , vol.21 , pp. 496-513
    • Liu, Y.M.1    Hsieh, C.R.2
  • 43
    • 0010707420 scopus 로고    scopus 로고
    • National Bureau of Economic Research, Cambridge, MA, Available from: last accessed 2013 Feb10
    • Lichtenberg FR. Sources of U.S. longevity increase, 1960-1997, National Bureau of Economic Research, Cambridge, MA, 2002. Available from: http://www.nber.org/papers/w8755, last accessed 2013 Feb 10.
    • (2002) Sources of U.S. longevity increase, 1960-1997
    • Lichtenberg, F.R.1
  • 45
    • 34548359291 scopus 로고    scopus 로고
    • Pharmaceutical-embodied technical progress, longevity, and quality of life: Drugs as 'Equipment for Your Health'
    • Lichtenberg FR, Virabhak S. Pharmaceutical-embodied technical progress, longevity, and quality of life: drugs as 'Equipment for Your Health'. Manage Decis Econ. 2007; 28: 371-392.
    • (2007) Manage Decis Econ. , vol.28 , pp. 371-392
    • Lichtenberg, F.R.1    Virabhak, S.2
  • 46
  • 47
    • 0346620161 scopus 로고    scopus 로고
    • The effect of new drug approvals on HIV mortality in the US, 1987-1998
    • Lichtenberg FR. The effect of new drug approvals on HIV mortality in the US, 1987-1998. Econ Hum Biol. 2003; 1: 259-266.
    • (2003) Econ Hum Biol. , vol.1 , pp. 259-266
    • Lichtenberg, F.R.1
  • 48
    • 44649159153 scopus 로고    scopus 로고
    • Recent trends of cancer in Europe: A combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s
    • Karim-Kos HE, de Vries E, Soerjomataram I, Lemmens V, Siesling S, Coebergh JW. Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer. 2008; 44: 1345-1389.
    • (2008) Eur J Cancer. , vol.44 , pp. 1345-1389
    • Karim-Kos, H.E.1    de Vries, E.2    Soerjomataram, I.3    Lemmens, V.4    Siesling, S.5    Coebergh, J.W.6
  • 50
    • 84872358725 scopus 로고    scopus 로고
    • The impact of new (orphan) drug approvals on premature mortality from rare diseases in the United States and France, 1999-2007
    • Lichtenberg FR. The impact of new (orphan) drug approvals on premature mortality from rare diseases in the United States and France, 1999-2007. Eur J Health Econ. 2013; 14:41-56.
    • (2013) Eur J Health Econ. , vol.14 , pp. 41-56
    • Lichtenberg, F.R.1
  • 51
    • 83655205469 scopus 로고    scopus 로고
    • OECD. OECD Publishing, Paris
    • OECD. Value for money in health spending. OECD Publishing, Paris, 2010, 167-173.
    • (2010) Value for money in health spending. , pp. 167-173
  • 52
    • 84905679177 scopus 로고    scopus 로고
    • Pharmacoeconomics and decision-making in health care: Current situation and future trends
    • Karampli E, Athanasakis K, Kyriopoulos J. Pharmacoeconomics and decision-making in health care: current situation and future trends. Iatriki. 2010; 98: 354-362.
    • (2010) Iatriki. , vol.98 , pp. 354-362
    • Karampli, E.1    Athanasakis, K.2    Kyriopoulos, J.3
  • 54
    • 78650121960 scopus 로고    scopus 로고
    • The relative value of medical innovations on population health status: Physicians' views in Greece
    • Athanasakis K, Konstantinou E, Thireos E, Kyriopoulos J. The relative value of medical innovations on population health status: Physicians' views in Greece. Archives of Hellenic Medicine. 2010; 27: 963-969.
    • (2010) Archives of Hellenic Medicine. , vol.27 , pp. 963-969
    • Athanasakis, K.1    Konstantinou, E.2    Thireos, E.3    Kyriopoulos, J.4
  • 55
    • 84870919541 scopus 로고    scopus 로고
    • Reforms in the Greek pharmaceutical market during the financial crisis
    • Vandoros S, Stargardt T. Reforms in the Greek pharmaceutical market during the financial crisis. Health Policy. 2013; 109: 1-6.
    • (2013) Health Policy. , vol.109 , pp. 1-6
    • Vandoros, S.1    Stargardt, T.2
  • 56
    • 34247252906 scopus 로고    scopus 로고
    • Pharmaceutical regulation in Greece at the crossroad of change: Economic, political and constitutional considerations for a new regulatory paradigm
    • Contiades X, Golna C, Souliotis K. Pharmaceutical regulation in Greece at the crossroad of change: economic, political and constitutional considerations for a new regulatory paradigm. Health Policy. 2007; 82: 116-129.
    • (2007) Health Policy. , vol.82 , pp. 116-129
    • Contiades, X.1    Golna, C.2    Souliotis, K.3
  • 57
    • 84892991693 scopus 로고    scopus 로고
    • Pharmaceutical innovation and longevity growth in 30 developing and high-income countries, 2000-2009
    • Lichtenberg FR. Pharmaceutical innovation and longevity growth in 30 developing and high-income countries, 2000-2009. Health Policy Technol. 2014; 3: 36-58.
    • (2014) Health Policy Technol. , vol.3 , pp. 36-58
    • Lichtenberg, F.R.1
  • 58
    • 84906972996 scopus 로고    scopus 로고
    • A (repeated) proposal for pharmaceutical policy reform in Greece
    • Souliotis K. A (repeated) proposal for pharmaceutical policy reform in Greece. Archives of Hellenic Medicine. 2013; 30: 520-521.
    • (2013) Archives of Hellenic Medicine. , vol.30 , pp. 520-521
    • Souliotis, K.1


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