Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence

Pathogens and Disease

Volumn 71, Issue 3, 2014, Pages 326-335

  Van Acker, Heleen ^a   Sass, Andrea ^a   Dhondt, Inne ^a   Nelis, Hans J ^a   Coenye, Tom ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Biofilm; Burkholderia; Persistence; TA modules

Indexed keywords

ANTITOXIN; BACTERIAL RNA; BACTERIAL TOXIN; CIPROFLOXACIN; TOBRAMYCIN; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN;

AGAR GEL ELECTROPHORESIS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOFILM; BURKHOLDERIA; BURKHOLDERIA CENOCEPACIA; BURKHOLDERIA CEPACIA; BURKHOLDERIA DOLOSA; BURKHOLDERIA MULTIVORANS; BURKHOLDERIA PSEUDOMALLEI; BURKHOLDERIA VIETNAMIENSIS; CONTROLLED STUDY; GENE OVEREXPRESSION; GENOMIC ISLAND; GROWTH INHIBITION; NONHUMAN; OPERON; PHENOTYPE; PLANKTON; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA SEQUENCE; TRANSCRIPTION INITIATION SITE; UPREGULATION; VECTOR CONTROL; WILD TYPE; DRUG EFFECTS; DRUG TOLERANCE; GENE EXPRESSION PROFILING; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL VIABILITY; PHYSIOLOGY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BIOFILMS; BURKHOLDERIA CENOCEPACIA; DRUG TOLERANCE; GENE EXPRESSION PROFILING; MICROBIAL VIABILITY;

EID: 84905692212     PISSN: None     EISSN: 2049632X     Source Type: Journal    
DOI: 10.1111/2049-632X.12177     Document Type: Article

References (34)

1. Ahidjo BA, Kuhnert D, McKenzie JL, Machowski EE, Gordhan BG, Arcus V, Abrahams GL & Mizrahi V (2011) VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS One 6: e21738.
2. Budde PP, Davis BM, Yuan J & Waldor MK (2007) Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J Bacteriol 189: 491-500.
3. Butt A, Muller C, Harmer N & Titball RW (2013) Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett 338: 86-94.
4. Cardona ST & Valvano MA (2005) An expression vector containing a rhamnose-inducible promoter provides tightly regulated gene expression in Burkholderia cenocepacia. Plasmid 54: 219-228.
5. Coenye T (2010) Social interactions in the Burkholderia cepacia complex: biofilms and quorum sensing. Future Microbiol 5: 1087-1099.
6. Cohen SN, Chang AC & Hsu L (1972) Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. P Natl Acad Sci USA 69: 2110-2114.
7. Cortes T, Schubert OT, Rose G, Arnvig KB, Comas I, Aebersold R & Young DB (2013) Genome-wide mapping of transcriptional start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis. Cell Rep 5: 1121-1131.
8. Costerton JW, Stewart PS & Greenberg EP (1999) Bacterial biofilms: a common cause of persistent infections. Science 284: 1318-1322.
9. Craig FF, Coote JG, Parton R, Freer JH & Gilmour NJ (1989) A plasmid which can be transferred between Escherichia coli and Pasteurella haemolytica by electroporation and conjugation. J Gen Microbiol 135: 2885-2890.
10. Figurski DH & Helinski DR (1979) Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. P Natl Acad Sci USA 76: 1648-1652.
11. Fux CA, Costerton JW, Stewart PS & Stoodley P (2005) Survival strategies of infectious biofilms. Trends Microbiol 13: 34-40.
12. Gerdes K & Maisonneuve E (2012) Bacterial persistence and toxin-antitoxin loci. Annu Rev Microbiol 66: 103-123.
13. Germain E, Castro-Roa D, Zenkin N & Gerdes K (2013) Molecular mechanism of bacterial persistence by HipA. Mol Cell 52: 248-254.
14. Gonzalez Barrios AF, Zuo R, Hashimoto Y, Yang L, Bentley WE & Wood TK (2006) Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol 188: 305-316.
15. Hall-Stoodley L, Costerton JW & Stoodley P (2004) Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol 2: 95-108.
16. Hoffmann S, Otto C, Kurtz S, Sharma CM, Khaitovich P, Vogel J, Stadler PF & Hackermuller J (2009) Fast mapping of short sequences with mismatches, insertions and deletions using index structures. PLoS Comput Biol 5: e1000502.
17. Jensen RB & Gerdes K (1995) Programmed cell death in bacteria: proteic plasmid stabilization systems. Mol Microbiol 17: 205-210.
18. Kasari V, Mets T, Tenson T & Kaldalu N (2013) Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli. BMC Microbiol 13: 45.
19. Kim Y, Wang X, Ma Q, Zhang XS & Wood TK (2009) Toxin-antitoxin systems in Escherichia coli influence biofilm formation through YjgK (TabA) and fimbriae. J Bacteriol 191: 1258-1267.
20. Kroger C, Dillon SC, Cameron AD et al. (2012) The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium. P Natl Acad Sci USA 109: E1277-E1286.
21. Lemos JA, Brown TA Jr, Abranches J & Burne RA (2005) Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules. FEMS Microbiol Lett 253: 251-257.
22. Leplae R, Geeraerts D, Hallez R, Guglielmini J, Dreze P & Van Melderen L (2011) Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families. Nucleic Acids Res 39: 5513-5525.
23. Lewis K (2008) Multidrug tolerance of biofilms and persister cells. Curr Top Microbiol Immunol 322: 107-131.
24. Magnuson RD (2007) Hypothetical functions of toxin-antitoxin systems. J Bacteriol 189: 6089-6092.
25. Mulcahy LR, Burns JL, Lory S & Lewis K (2010) Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J Bacteriol 192: 6191-6199.
26. Peeters C, Zlosnik JE, Spilker T, Hird TJ, Lipuma JJ & Vandamme P (2013) Burkholderia pseudomultivorans sp. nov., a novel Burkholderia cepacia complex species from human respiratory samples and the rhizosphere. Syst Appl Microbiol 36: 483-489.
27. Robson J, McKenzie JL, Cursons R, Cook GM & Arcus VL (2009) The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. J Mol Biol 390: 353-367.
28. Rotem E, Loinger A, Ronin I, Levin-Reisman I, Gabay C, Shoresh N, Biham O & Balaban NQ (2010) Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence. P Natl Acad Sci USA 107: 12541-12546.
29. Sevin EW & Barloy-Hubler F (2007) rasta-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes. Genome Biol 8: R155.
30. Van Acker H, Sass A, Bazzini S et al. (2013) Biofilm-grown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species. PLoS One 8: e58943.
31. Van Melderen L & Saavedra De Bast M (2009) Bacterial toxin-antitoxin systems: more than selfish entities? PLoS Genet 5: e1000437.
32. Wang X & Wood TK (2011) Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response. Appl Environ Microbiol 77: 5577-5583.
33. Wang X, Lord DM, Cheng HY et al. (2012) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat Chem Biol 8: 855-861.
34. Yamaguchi Y, Park JH & Inouye M (2011) Toxin-antitoxin systems in bacteria and archaea. Annu Rev Genet 45: 61-79.