Study on in vivo pharmacokinetics of cucurbitacin injection in rats

Zhongguo Zhongyao Zazhi

Volumn 39, Issue 11, 2014, Pages 2126-2129

  Xu, Xiao Ting ^a,b,c   Deng, Zhi Peng ^a,c   Fan, Hui Xia ^a,b,c   Zhong, Hao ^a,c   Yao, Qing Qiang ^a,c  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF JINAN   (China)

^c Key Laboratory for Rare and Uncommon Diseases of Shandong   (China)

Author keywords

Cucurbitacin; LC MS MS; Pharmacokinetic characteristics

Indexed keywords

CUCURBITACIN; DIPHENHYDRAMINE; FORMIC ACID; METHANOL; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; NONHUMAN; POSITIVE ION ELECTROSPRAY; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; BLOOD; CHEMISTRY; CUCURBITACEAE; MALE; ORAL DRUG ADMINISTRATION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CUCURBITACEAE; CUCURBITACINS; DRUGS, CHINESE HERBAL; MALE; RATS; RATS, WISTAR;

EID: 84905676824     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20141136     Document Type: Article

References (5)

1. Chen J C, Niu X M, Li Z R, et al. Four new cucurbitane glycosides from Hemsleya jinfushanensis[J]. Planta Med, 2005, 71(10): 983.
2. Fuller R W, Cardellina J H, Cragg G M, et al. Cucurbitacins: differential cytotoxicity, dereplication and first isolation from Gonystylus keithii[J]. J Nat Prod, 1994, 57(10): 1442.
3. Boykin C, Zhang G, Chen Y, et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation[J]. Brit J Cancer, 2011, 104(5):781.
4. Alghasham A A. Cucurbitacins-a promising target for cancer therapy [J]. Int J Health Sci, 2013, 7(1): 77.
5. Tian R R, Chen J C, Zhang G H, et al. Anti-HIV-1 activities of hemslecins A and B[J]. Chin J Nat Med, 2008, 6(3): 214.