Tobramycin nebulizer solution in severe COPD patients colonized with pseudomonas aeruginosa: Effects on bronchial inflammation

Advances in Therapy

Volumn 25, Issue 10, 2008, Pages 1019-1030

  Dal Negro, Roberto ^a   Micheletto, Claudio ^a   Tognella, Silvia ^a   Visconti, Marilia ^a   Turati, Claudio ^a  

^a Ospedale Orlandi   (Italy)

Author keywords

Airway inflammation; Bronchial secretions; COPD exacerbations; Cytokines; Pseudomonas aeruginosa; Tobramycin

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM; CEFTAZIDIME; CIPROFLOXACIN; EOSINOPHIL CATIONIC PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; SULTAMICILLIN; TOBRAMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFECT; EOSINOPHIL COUNT; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; TREATMENT RESPONSE; CHEMISTRY; CLINICAL TRIAL; MICROBIOLOGY; NEBULIZER; SPUTUM;

AGED; BRONCHITIS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; NEBULIZERS AND VAPORIZERS; PSEUDOMONAS AERUGINOSA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SPUTUM; TOBRAMYCIN;

EID: 61749103937     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12325-008-0105-2     Document Type: Article

References (35)

1. K.F. Rabe S. Hurd A. Anzueto 2007 Global Initiative for Chronic Obstructive Lung Diseas Pawels. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary Am J Respir Crit Care Med. 176 532 555 10.1164/rccm.200703-456SO 17507545 (Pubitemid 47403272)
2. S. Ilurd 2000 The impact of COPD on lung health worldwide: epidemiology and incidence Chest 117 1 4 10.1378/chest.117.1.1
3. S. Sethi 2000 Infectious etiology of acute exacerbations of chronic bronchitis Chest. 117 suppl.2 380 385 (Pubitemid 32001777)
4. T.A.R. Seemungal G.C. Donaldson E.A. Paul 1998 Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med. 157 1418 1422 (Pubitemid 28242071)
5. K.H. Groenewegen A.M.W.J. Schols E.F.M. Wouters 2003 Mortality and mortalityrelated factors after hospitalization for acute exacerbation of COPD Chest. 124 459 467 10.1378/chest.124.2.459 12907529 (Pubitemid 37000120)
6. E. Monso A. Rossel G. Bonet 1999 Risk factors for lower airway bacterial colonization in chronic bronchitis Eur Respir J. 13 338 342 (Pubitemid 29086830)
7. R.W. Dal Negro A. Rossi I. Cerveri 2003 The burden of COPD in Italy: results from the confronting COPD survey Respir Med. 97 suppl.C 43 50 (Pubitemid 36266869)
8. R. Dal Negro 2008 Optimizing economic outcomes in the management of COPD Int J COPD. 3 1 10 (Pubitemid 351523714)
9. M. Miravitlles C. Murio T. Guerrero R. Gisbert 2002 Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD Chest. 121 1449 1455 10.1378/chest.121.5.1449 12006427 (Pubitemid 34499654)
10. R.W. Dal Negro S. Tognella R. Tosatto M. Dionisi P. Turco C.F. Donner 2008 Costs of chronic obstructive pulmonary disease (COPD) in Italy: the SIRIO study (Social Impact of Respiratory Integrated Outcomes) Respir Med. 102 92 101 10.1016/j.rmed.2007.08.001 (Pubitemid 350161843)
11. A.J. White S. Gompertz R.A. Stocley 2003 Chronic obstructive pulmonary disease 6: the aetiology of exacerbations of chronic obstructive pulmonary disease Thorax. 58 73 80 10.1136/thorax.58.1.73 12511727 (Pubitemid 36135363)
12. R. Wilson R. Grossman 2000 Introduction: the role of bacteria infection in chronic bronchitis Semin Respir Infect. 15 1 6 10.1053/srin.2000.0150001 10749544 (Pubitemid 30159931)
13. S. Sethi 1998 Management of acute exacerbations of chronic bronchitis Infect Dis Clin Pract. 7 300 308 10.1097/00019048-199812005-00004 (Pubitemid 28553341)
14. S. Sethi K. Muscarella N. Evans 2000 Airway inflammation and etiology of acute exacerbations of chronic bronchitis Chest. 118 1557 1565 10.1378/chest.118.6.1557 11115440 (Pubitemid 32001777)
15. J.V. Hirschmann 2000 Do bacteria cause exacerbation of COPD? Chest. 118 193 203 10.1378/chest.118.1.193 10893379
16. I.S. Patel T.A.R. Seemungal M. Wilks S.J. Lloyd-Owen G.C. Donaldson J.A. Wedzicha 2002 Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations Thorax. 57 759 764 10.1136/thorax.57.9.759 12200518 (Pubitemid 34984972)
17. N. Lechtzin M. John R. Irizarry C. Merlo G.B. Diette M. Boyle 2006 Outcomes of adults with cystic fibrosis infected with antibioticresistant Pseudomonas aeruginosa Respiration. 73 27 33 10.1159/000087686 16113513 (Pubitemid 43296235)
18. E. Caballero M.E. Drobnic M.T. Pérez J.M. Manresa R. Orriols 2001 Anti-Pseudomonas aerugionosa antibody detection in patients with bronchiectasis without cystic fibrosis Thorax. 56 669 674 10.1136/thorax.56.9.669 11514685 (Pubitemid 32831692)
19. R.W. Dal Negro C. Micheletto S. Tognella M. Visconti M. Guerriero M.F. Sandri 2005 A two-stage logistic model based on the measurement of proinflammatory cytokines in bronchial secretions for assessing bacterial, viral, and non-infectious origin of COPD exacerbations COPD. 2 7 16 10.1081/COPD-200050680 (Pubitemid 40776217)
20. T.F. Murphy A.L. Brauer K. Eschberger 2008 Pseudomonas aeruginosa in chronic obstructive pulmonary disease Am J Respir Crit Care Med. 177 853 860 10.1164/rccm.200709-1413OC 18202344 (Pubitemid 351600663)
21. D.E. Geller W. Pitlick P.A. Nardella W. Tracewell B.W. Ransey 2002 Pharmacokinetics and bioavailability of aerosolized Tobramycin in cystic fibrosis Chest. 122 219 226 10.1378/chest.122.1.219 12114362 (Pubitemid 34754166)
22. A.F. Barker S.B. Fiel M.H. Gotfried 2000 Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis Am J Respir Crit Care Med. 162 481 485 10934074
23. N.R. Anthonisen J. Manfreda C.P. Warren 1987 Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease Ann Intern Med. 106 196 204 3492164 (Pubitemid 17009877)
24. Barrow GI, Feltman RK. Cowan and Steel's Manual for the Identification of Medical Bacteria. 3rd edition. Cambridge: Cambridge University press; 1993.
25. F. Berthier C. Lambert C. Genin J. Bienvenu 1999 Evaluation of an automated immunoassay method for cytokine measurement using the Immulite Immunoassay system Clin Chem Lab Med. 37 593 599 10.1515/CCLM.1999.092 10418750 (Pubitemid 29304424)
26. O.A. Khair J.L. Devalia M.M. Abdelaziz 1994 Effect of erythromycin on Haemophilus influenzae endotoxin-induced release of IL-6, IL-8 and sICAM-1 by cultured human bronchial epithelial cells Eur Respir J. 7 2109 2116 10.1183/09031936.94.07122109 7713191
27. A.T. Hill E.J. Campbel S.L. Hill 2000 Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis Am J Med. 109 288 295 10.1016/S0002-9343(00)00507-6 10996579
28. N. Soler S. Ewing A. Torres 1999 Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease Eur Respir J. 14 1015 1022 10.1183/09031936.99.14510159 10596683 (Pubitemid 29091749)
29. A.L. Pukhalsky N.I. Kapranov E.A. Kalashnikova 1999 Inflammatory markers in cystic fibrosis patients with lung Pseudomonas aeruginosa infection Mediators Inflamm. 8 159 167 10.1080/09629359990496 10704054 (Pubitemid 29332055)
30. M.O. Husson N. Wizla-Derambure D. Turck P. Gosset B. Wallaert 2005 Effect of intermittent inhaled tobramycin on sputum cytokine profiles in cystic fibrosis J Antimicrob Chemother. 56 247 249 10.1093/jac/dki179 15932936 (Pubitemid 41418368)
31. A. Bhowmik T.A.R. Seemugal R.J. Sapsford 2000 Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations Thorax. 55 114 120 10.1136/thorax.55.2.114 10639527 (Pubitemid 30245950)
32. M.E. Drobnic P. Suné J.B. Montoro A. Ferrer R. Orriols 2005 Inhaled Tobramycin in noncystic fibrosis patients with bronchiectasis and chronic bronchial infection with pseudomonas aeruginosa Ann Pharmacother. 39 39 44 15562142 (Pubitemid 40052376)
33. P. Scheinberg E. Shore 2005 A pilot study of the safety and efficacy of Tobramycin solution for inhalation in patients with severe bronchiectasis Chest. 127 1420 1426 10.1378/chest.127.4.1420 15821224 (Pubitemid 46224309)
34. J.S. Olowite M.S. Niederman A.M. Fein 1991 Delivery of topical antibiotics: pharmacokinetics and clinical problem Semin Respir Infect. 6 158 167
35. D.Y. Koller M. Gotz C. Wojnarowski I. Eichler 1996 Relationship between disease severity and inflammation markers in cystic fibrosis Arch Dis Child. 75 498 501 10.1136/adc.75.6.498 9014602 (Pubitemid 27008210)