Molecular mechanisms for the inheritance of acquired characteristics-exosomes, microRNA shuttling, fear and stress: Lamarck resurrected?

Frontiers in Genetics

Volumn 5, Issue MAY, 2014, Pages

  Smythies, John ^a   Edelstein, Lawrence ^b   Ramachandran, Vilayanur ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Medimark Corporation   (United States)

Author keywords

Epididymis; Epigenetics; Exosomes; Lamarck; MicroRNAs; Sperm; Transgenerational inheritance

Indexed keywords

EID: 84905669699     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00133     Document Type: Article

References (24)

1. Barckmann, B., and Simonelig, M. (2013). Control of maternal mRNA stability in germ cells and early embryos. Biochim. Biophys. Acta 1829, 714-724. doi: 10.1016/j.bbagrm.2012.12.011
2. Belleannée, C., Calvo, é., Caballero, J., and Sullivan, R. (2013). Epididymosomes convey different repertoires of microRNAs throughout the bovine epididymis. Biol. Reprod. 89, 30. doi: 10.1095/biolreprod.113.110486
3. Dias, B. G., and Ressler, K. J. (2014). Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat. Neurosci. 17, 89-96. doi: 10.1038/nn.3594
4. Edelstein, L., and Smythies, J. (2014). Epigenetic aspects of telocytes/cordocytes: jacks of all trades, masters of most. Front. Cell. Neurosci. 8:32. doi: 10.3389/fncel.2014.00032
5. Fullston, T., Ohlsson Teague, E. M. C., Palmer, N. O., DeBlasio, M. J., Mitchell, M., et al. (2013). Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB J. 27, 4226-4243. doi: 10.1096/fj.12-224048
6. Gapp, K., Jawaid, A., Sarkies, P., Bohacek, J., Pelczar, P., Prados, J., et al. (2014). Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nat. Neurosci. 17, 667-669. doi: 10.1038/nn.3695
7. Gupta, A., and Pulliam, L. (2014). Exosomes as mediators of neuroinflammation. J. Neuroinflamm. 11:68. doi: 10.1186/1742-2094-11-68
8. Gursky, V. V., Panok, L., Myasnikova, E. M., Manu, Samsonova, M. G., Reinitz, J., et al. (2011). Mechanisms of gap gene expression canalization in the Drosophila blastoderm. BMC Syst. Biol. 5:118. doi: 10.1186/1752-0509-5-118
9. Gustaffson, A. (1979). Linnaeus' Peloria: the history of a monster. Theor. Appl. Genet. 54, 241-248. doi: 10.1007/BF00281206
10. Hossain, M. M., Sohel, M. M. H., Schellander, K., and Tesfaye, D. (2012). Characterization and importance of microRNAs in mammalian gonadal function. Cell Tissue Res. 349, 679-690. doi: 10.1007/s00441-012-1469-6
11. Jodar, M., Selvaraju, S., Sendler, E., Diamond, M. P., and Krawetz, S. A. (2013). The presence, role and clinical use of spermatozoal RNAs. Hum. Reprod. Update 19, 604-624. doi: 10.1093/humupd/dmt031
12. Kalani, A., Tyagi, A., and Tyagi, N. (2014). Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol. Neurobiol. 49, 590-600. doi: 10.1007/s12035-013-8544-1
13. Kawano, M., Kawaji, H., Grandjean, V., Kiani, J., and Rassoulzadegan, M. (2012). Novel small noncoding RNAs in mouse spermatozoa, zygotes and early embryos. PLoS ONE 7:e44542. doi: 10.1371/journal.pone.0044542
14. Kumar, M., Kumar, K., Jain, S., Hassan, T., and Dada, R. (2013). Novel insights into the genetic and epigenetic paternal contribution to the human embryo. Clinics (Sao. Paulo) 68(Suppl. 1), 5-14. doi: 10.6061/clinics/2013(Sup01)02
15. Marczylo, E., Amoako, A. A., Konje, J. C., Gant, T. W., and Marczylo, T. H. (2012). Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern? Epigenetics 7, 432-439. doi: 10.4161/epi.19794
16. Marques-Pita, M., and Rocha, L. M. (2013). Canalization and control in automata networks: body segmentation in Drosophila melanogaster. PLoS ONE 8:e55946. doi: 10.1371/journal.pone.0055946
17. Pusic, A. D., Pusic, K. M., and Kraig, R. P. (2014). What are exosomes and how can they be used in multiple sclerosis therapy? Expert Rev. Neurother. 14, 353-355. doi: 10.1586/14737175.2014.890893
18. Rodgers, A. B., Morganm, C. P., Bronsonm, S. L., Revello, S., and Bale, T. L. (2013). Paternal stress exposure alters sperm microrna content and reprograms offspring hpa stress axis regulation. J. Neurosci. 33, 9003-9012. doi: 10.1523/JNEUROSCI.0914-13.2013
19. Sahoo, S., Douglas, W., and Losordo, D. W. (2014). Exosomes and cardiac repair after myocardial infarction. Circ. Res. 114, 333-344. doi: 10.1161/CIRCRESAHA.114.300639
20. Sampey, G. C., Meyering, S. S., Asad Zadeh, M., Saifuddin, M., Hakami, R. M., and Kashanchi, F. (2014). Exosomes and their role in CNS viral infections. J. Neurovirol. doi: 10.1007/s13365-014-0238-6. [Epub ahead of print].
21. Smythies, J., and Edelstein, L. (2013a). Transsynaptic modality codes in the brain: possible involvement of synchronized spike timing, microRNAs, exosomes and epigenetic processes. Front. Intregr. Neurosci. 6:126. doi: 10.3389/fnint.2012.00126
22. Smythies, J., and Edelstein, L. (2013b). Telocytes, exosomes, gap junctions and the cytoskeleton: the makings of a primitive nervous system? Front. Cell. Neurosci. 7:278. doi: 10.3389/fncel.2013.00278
23. Stringer, J. M., Barrand, S., and Western, P. (2013). Fine-tuning evolution: germ-line epigenetics and inheritance. Reproduction 146, R37-R48. doi: 10.1530/REP-12-0526
24. Sullivan, R., Saez, F., Girouard, J., and Frenette, G. (2005). Role of exosomes in sperm maturation during the transit along the male reproductive tract. Blood Cells Mol. Dis. 35, 1-10. doi: 10.1016/j.bcmd.2005.03.005