Mesenchymal stem cells ameliorate diabetic glomerular fibrosis in vivo and in vitro by inhibiting TGF-β signalling via secretion of bone morphogenetic protein 7

Diabetes and Vascular Disease Research

Volumn 11, Issue 4, 2014, Pages 251-261

  Lv, Shasha ^a   Liu, Gang ^a   Sun, Aili ^a   Wang, Jianping ^b   Cheng, Jing ^a   Wang, Weiwei ^a   Liu, Xiangchun ^a   Nie, Huibin ^a   Guan, Guangju ^a  

^a SHANDONG UNIVERSITY   (China)

^b YANTAI YUHUANGDING HOSPITAL   (China)

Author keywords

Bone marrow mesenchymal stem cells; Bone morphogenetic protein 7; Diabetic nephropathy; Fibrosis; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; GLUCOSE; NEUTRALIZING ANTIBODY; OSTEOGENIC PROTEIN 1; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC GLOMERULAR FIBROSIS; DIABETIC NEPHROPATHY; FEMALE; GLOMERULOSCLEROSIS; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PARACRINE SIGNALING; PERIODIC ACID SCHIFF STAIN; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS;

EID: 84905649897     PISSN: 14791641     EISSN: 17528984     Source Type: Journal    
DOI: 10.1177/1479164114531300     Document Type: Article

References (30)

1. Collins AJ, Foley RN, Herzog C, et al. US Renal Data System 2012 annual data report. Am J Kidney Dis 2013; 61: A7, e1-476.
2. Collins AJ, Foley RN, Gilbertson DT, et al. The state of chronic kidney disease, ESRD, and morbidity and mortality in the first year of dialysis. Clin J Am Soc Nephrol 2009; 4: S5-S11.
3. Li JH, Huang XR, Zhu H-J, et al. Role of TGF-β signalling in extracellular matrix production under high glucose conditions. Kidney Int 2003; 63: 2010-2019.
4. Reeves WB and Andreoli TE. Transforming growth factor β contributes to progressive diabetic nephropathy. Proc Natl Acad Sci USA 2000; 97: 7667-7669.
5. Basile DP. Transforming growth factor-beta as a target for treatment in diabetic nephropathy. Am J Kidney Dis 2001; 38: 887-892.
6. Yanagita M. Inhibitors/antagonists of TGF-β system in kidney fibrosis. Nephrol Dial Transplant 2012; 27: 3686-3691.
7. Lan HY. Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens 2003; 12: 25-29.
8. Chen S, Iglesias-de la Cruz MC, Jim B, et al. Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem Biophys Res Commun 2003; 300: 16-22.
9. Benigni A, Zoja C, Corna D, et al. Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat. J Am Soc Nephrol 2003; 14: 1816-1824
10. Ziyadeh FN, Hoffman BB, Han DC, et al. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factorbeta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 2000; 97: 8015-8020
11. Morigi M, Introna M, Imberti B, et al. Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice. Stem Cells 2008; 26: 2075-2082
12. Morigi M, Imberti B, Zoja C, et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 2004; 15: 1794-1804
13. Semedo P, Correa-Costa M, Antonio Cenedeze M, et al. Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model. Stem Cells 2009; 27: 3063-3073
14. Kunter U, Rong S, Djuric Z, et al. Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis. J Am Soc Nephrol 2006; 17: 2202-2212
15. Lv S-S, Liu G, Wang J-P, et al. Mesenchymal stem cells transplantation ameliorates glomerular injury in streptozotocin- induced diabetic nephropathy in rats via inhibiting macrophage infiltration. Int Immunopharmacol 2013; 17: 275-282
16. Ezquer FE, Ezquer ME, Parrau DB, et al. Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice. Biol Blood Marrow Transplant 2008; 14: 631-640
17. Ezquer F, Ezquer M, Simon V, et al. Endovenous administration of bone-marrow-derived multipotent mesenchymal stromal cells prevents renal failure in diabetic mice. Biol Blood Marrow Transplant 2009; 15: 1354-1365
18. Wang S, Li Y, Zhao J, et al. Mesenchymal stem cells ameliorate podocyte injury and proteinuria in a type 1 diabetic nephropathy rat model. Biol Blood Marrow Transplant 2013; 19: 538-546
19. Bruno S, Grange C, Deregibus MC, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009; 20: 1053-1067
20. Van Koppen A, Joles JA, van Balkom BW, et al. Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease. PLoS One 2012; 7: e38746.
21. Eliopoulos N, Zhao J, Bouchentouf M, et al. Human marrow- derived mesenchymal stromal cells decrease cisplatin renotoxicity in vitro and in vivo and enhance survival of mice post-intraperitoneal injection. Am J Physiol Renal Physiol 2010; 299: F1288-F1298
22. Park JH, Hwang I, Hwang SH, et al. Human umbilical cord blood-derived mesenchymal stem cells prevent diabetic renal injury through paracrine action. Diabetes Res Clin Pract 2012; 98: 465-473
23. Si Y, Zhao Y, Hao H, et al. Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity. Diabetes 2012; 61: 1616-1625
24. Lindoso RS, Araujo DS, Adao-Novaes J, et al. Paracrine interaction between bone marrow-derived stem cells and renal epithelial cells. Cell Physiol Biochem 2011; 28: 267-278
25. Tesch GH and Allen TJ. Rodent models of streptozotocininduced diabetic nephropathy (Methods in Renal Research). Nephrology 2007; 12: 261-266
26. Lee RH, Seo MJ, Reger RL, et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/ scid mice. Proc Natl Acad Sci USA 2006; 103: 17438-17443
27. Li D, Wang N, Zhang L, et al. Mesenchymal stem cells protect podocytes from apoptosis induced by high glucose via secretion of epithelial growth factor. Stem Cell Res Ther 2013; 4: 103
28. Wang S, Chen Q, Simon TC, et al. Bone morphogenic protein- 7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int 2003; 63: 2037-2049
29. Mitu GM, Wang S and Hirschberg R. BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Renal Physiol 2007; 293: F1641-F1648
30. Zhang XL, Selbi W, de la Motte C, et al. Bone morphogenic protein-7 inhibits monocyte-stimulated TGF-β1 generation in renal proximal tubular epithelial cells. J Am Soc Nephrol 2005; 16: 79-89.