Adenovirus causing fever, upper respiratory infection, and allograft nephritis complicated by persistent asymptomatic viremia

Transplant Infectious Disease

Volumn 16, Issue 4, 2014, Pages 648-652

  Lachiewicz, A M ^a   Cianciolo, R ^a   Miller, M B ^a   Derebail, V K ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; Cidofovir; Granulomatous interstitial nephritis; Immunosuppression; Kidney transplant; Viremia

Indexed keywords

ANTIVIRUS AGENT; CIDOFOVIR; CYTOSINE; IMMUNOGLOBULIN; PHOSPHONIC ACID DERIVATIVE;

ADENOVIRIDAE; ADENOVIRUS INFECTIONS, HUMAN; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; CASE REPORT; CLASSIFICATION; DRUG COMBINATION; FEMALE; HUMAN; IMMUNOCOMPROMISED PATIENT; INTERSTITIAL NEPHRITIS; ISOLATION AND PURIFICATION; KIDNEY TRANSPLANTATION; PATHOLOGY; RESPIRATORY TRACT INFECTION; VIREMIA; VIROLOGY; YOUNG ADULT;

ADENOVIRIDAE; ADENOVIRUS INFECTIONS, HUMAN; ANTIVIRAL AGENTS; CYTOSINE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOGLOBULINS, INTRAVENOUS; KIDNEY TRANSPLANTATION; NEPHRITIS, INTERSTITIAL; ORGANOPHOSPHONATES; RESPIRATORY TRACT INFECTIONS; VIREMIA; YOUNG ADULT;

EID: 84905585768     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/tid.12248     Document Type: Article

References (14)

1. Florescu DF, Hoffman JA. Adenovirus in solid organ transplantation. Am J Transplant 2013; 13 (Suppl 4): 206-211.
2. Florescu MC, Miles CD, Florescu DF. What do we know about adenovirus in renal transplantation? Nephrol Dial Transplant 2013; 28 (8): 2003-2010.
3. Lu X, Erdman DD. Molecular typing of human adenoviruses by PCR and sequencing of a partial region of the hexon gene. Arch Virol 2006; 151 (8): 1587-1602.
4. Leruez-Ville M, Minard V, Lacaille F, et al. Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin Infect Dis 2004; 38 (1): 45-52.
5. Echavarria M. Adenoviruses in immunocompromised hosts. Clin Microbiol Rev 2008; 21 (4): 704-715.
6. Watcharananan SP, Avery R, Ingsathit A, et al. Adenovirus disease after kidney transplantation: course of infection and outcome in relation to blood viral load and immune recovery. Am J Transplant 2011; 11 (6): 1308-1314.
7. Sive JI, Thomson KJ, Morris EC, Ward KN, Peggs KS. Adenoviremia has limited clinical impact in the majority of patients following alemtuzumab-based allogeneic stem cell transplantation in adults. Clin Infect Dis 2012; 55 (10): 1362-1370.
8. Humar A, Kumar D, Mazzulli T, et al. A surveillance study of adenovirus infection in adult solid organ transplant recipients. Am J Transplant 2005; 5 (10): 2555-2559.
9. Ljungman P, Ribaud P, Eyrich M, et al. Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2003; 31 (6): 481-486.
10. Kuypers DR, Bammens B, Claes K, Evenepoel P, Lerut E, Vanrenterghem Y. A single-centre study of adjuvant cidofovir therapy for BK virus interstitial nephritis (BKVIN) in renal allograft recipients. J Antimicrob Chemother 2009; 63 (2): 417-419.
11. Kerensky T, Hasan A, Schain D, et al. Histopathologic resolution of adult liver transplantation adenovirus hepatitis with cidofovir and intravenous immunoglobulin: a case report. Transplant Proc 2013; 45 (1): 293-296.
12. Saquib R, Melton LB, Chandrakantan A, et al. Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin. Transpl Infect Dis 2010; 12 (1): 77-83.
13. Florescu DF, Pergam SA, Neely MN, et al. Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients. Biol Blood Marrow Transplant 2012; 18 (5): 731-738.
14. Storsley L, Gibson IW. Adenovirus interstitial nephritis and rejection in an allograft. J Am Soc Nephrol 2011; 22 (8): 1423-1427.