Nevirapine-resistant HIV-1 DNA in breast milk after single-dose nevirapine with or without zidovudine for prevention of mother-to-child transmission

Journal of the Pediatric Infectious Diseases Society

Volumn 1, Issue 3, 2012, Pages 244-249

  Gantt, Soren ^a,b   Payant, Rachel ^b   Carlsson, Jacquelyn ^b   Micek, Mark A ^a,c   Blanco, Ana Judith ^a,c   Beck, Ingrid A ^b   Matunha, Laurinda ^c   Montoya, Pablo ^a,c   Matediana, Eduardo ^d   Gloyd, Stephen ^a,c   Frenkel, Lisa M ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE CHILDREN S HOSPITAL   (United States)

^c HEALTH ALLIANCE INTERNATIONAL   (United States)

^d Mozambique Ministry of Health   (Mozambique)

Author keywords

[No Author keywords available]

Indexed keywords

NEVIRAPINE; VIRUS DNA; ZIDOVUDINE;

ANTIVIRAL RESISTANCE; ARTICLE; BREAST FEEDING; BREAST MILK; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFANT; MAJOR CLINICAL STUDY; MOTHER TO CHILD TRANSMISSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE DRUG DOSE; VIRUS LOAD; VIRUS TRANSMISSION;

EID: 84905585151     PISSN: 20487193     EISSN: 20487207     Source Type: Journal    
DOI: 10.1093/jpids/pis065     Document Type: Article

References (12)

1. Jackson JB, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 2003; 362:859-68.
2. Lockman S, Hughes MD, McIntyre J, et al. Antiretroviral therapies in women after single-dose nevirapine exposure. N Engl J Med 2010; 363:1499-509.
3. Palumbo P, Lindsey JC, Hughes MD, et al. Antiretroviral treatment for children with peripartum nevirapine exposure. N Engl J Med 2010; 363:1510-20.
4. Hudelson SE, McConnell MS, Bagenda D, et al. Emergence and persistence of nevirapine resistance in breast milk after single-dose nevirapine administration. AIDS 2010; 24:557-61.
5. Pilger D, Hauser A, Kuecherer C, et al. Minor drug-resistant HIV type-1 variants in breast milk and plasma of HIV type-1-infected Ugandan women after nevirapine single-dose prophylaxis. Antivir Ther 2011; 16:109-13.
6. Moorthy A, Gupta A, Bhosale R, et al. Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants. PLoS One 2009; 4:e4096.
7. Micek MA, Blanco AJ, Beck IA, et al. Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine. Clin Infect Dis 2010; 50:1405-14.
8. Wagner TA, Kress CM, Beck I, et al. Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay. J Clin Microbiol 2010; 48:1555-61.
9. Micek MA, Blanco AJ, Carlsson J, et al. Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine. J Infect Dis. In press.
10. Beck IA, Drennan KD, Melvin AJ, et al. Simple, sensitive, and specific detection of human immunodeficiency virus type 1 subtype B DNA in dried blood samples for diagnosis in infants in the field. J Clin Microbiol 2001; 39:29-33.
11. Gantt S, Shetty AK, Seidel KD, et al. Laboratory indicators of mastitis are not associated with elevated HIV-1 DNA loads or predictive of HIV-1 RNA loads in breast milk. J Infect Dis 2007; 196:570-6.
12. Gantt S, Carlsson J, Heath L, et al. Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis. J Virol 2010; 84:10812-9.