Real-Time Elastography in the Assessment of Liver Fibrosis: A Review of Qualitative and Semi-quantitative Methods for Elastogram Analysis

Ultrasound in Medicine and Biology

Volumn 40, Issue 9, 2014, Pages 1923-1933

  Paparo, Francesco ^a   Corradi, Francesco ^a   Cevasco, Luca ^b   Revelli, Matteo ^b   Marziano, Andrea ^a   Molini, Lucio ^a   Cenderello, Giovanni ^a   Cassola, Giovanni ^a   Rollandi, Gian Andrea ^a  

^a GALLIERA HOSPITAL   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Elastic ratio; Fibrosis index; Liver fibrosis; Real time elastography

Indexed keywords

STIFFNESS; ULTRASONIC APPLICATIONS;

COLOR-CODED MAPS; ELASTIC PROPERTIES; ELASTIC RATIO; FIBROSIS INDEX; INTEROBSERVER VARIABILITY; LIVER FIBROSIS; QUALITATIVE ANALYSIS; REAL-TIME ELASTOGRAPHY;

MEDICAL IMAGING;

DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DIGESTIVE TRACT PARAMETERS; ELASTIC RATIO; ELASTOGRAPHY; FIBROSIS INDEX; HISTOGRAM; HUMAN; IMAGE ANALYSIS; INTERMETHOD COMPARISON; LIVER FIBROSIS; LIVER PARENCHYMA; LIVER PARENCHYMA STIFFNESS; OUTCOME ASSESSMENT; PHYSICAL PARAMETERS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REAL TIME ELASTOGRAPHY; REVIEW; TISSUE CHARACTERIZATION; COMPUTER SYSTEM; ECHOGRAPHY; IMAGE PROCESSING; LIVER; LIVER CIRRHOSIS; OBSERVER VARIATION; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

COMPUTER SYSTEMS; ELASTICITY IMAGING TECHNIQUES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIVER; LIVER CIRRHOSIS; OBSERVER VARIATION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84905580667     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2014.03.021     Document Type: Review

References (37)

1. Athanasiou A., Tardivon A., Tanter M., Sigal-Zafrani B., Bercoff J., Deffieux T., Gennisson J.L., Fink M., Neuenschwander S. Breast lesions: Quantitative elastography with supersonic shear imaging-preliminary results. Radiology 2010, 256:297-303.
2. Bamber J., Cosgrove D., Dietrich C.F., Fromageau J., Bojunga J., Calliada F., Cantisani V., Correas J.M., D'Onofrio M., Drakonaki E.E., Fink M., Friedrich-Rust M., Gilja O.H., Havre R.F., Jenssen C., Klauser A.S., Ohlinger R., Saftoiu A., Schaefer F., Sporea I., Piscaglia F. EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography: Part 1. Basic principles and technology. Ultraschall Med 2013, 34:169-184.
3. Bavu E., Gennisson J.L., Couade M., Bercoff J., Mallet V., Fink M., Badel A., Vallet-Pichard A., Nalpas B., Tanter M., Pol S. Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: A clinical study on 113 hepatitis C virus patients. Ultrasound Med Biol 2011, 37:1361-1373.
4. Bavu E., Gennisson J.L., Mallet V., Osmanski B.F., Coaude M., Bercoff J., Fink M., Sogni P., Vallet-Pichard A., Nalpas B. Supersonic shear imaging is a new potent morphologic non-invasive technique to assess liver fibrosis: Part II. Comparison with Fibroscan. J Hepatol 2010, 52:S166.
5. Bedossa O., Dargère D., Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003, 38:1449-1457.
6. Boursier J., Konatè A., Gorea G., Reaud S., Quemener E., Oberti F., Hubert-Fouchard I., Dib N., Calés P. Reproducibility of liver stiffness measurement by ultrasonographic elastometry. Clin Gastroenterol Hepatol 2008, 6:1263-1269.
7. Colombo S., Buonocore M., Del Poggio A., Jamoletti C., Elia S., Mattiello M., Zabbialini D., Del Poggio P. Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis. J Gastroenterol 2012, 47:461-469.
8. Corradi F., Piscaglia F., Flori S., D'Errico-Grigioni A., Vasuri F., Tamè M.R., Andreone P., Boni P., Gianstefani A., Bolondi L. Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: Usefulness of transient elastography. Dig Liver Dis 2009, 41:217-225.
9. Ferraioli G., Tinelli C., Malfitano A., Dal Bello B., Filice G., Filice C., Liver Fibrosis Study Group, Above E., Barbarini G., Brunetti E., Calderon W., Di Gregorio M., Lissandrin R., Ludovisi S., Maiocchi L., Michelone G., Mondelli M., Patruno S.F., Perretti A., Poma G., Sacchi P., Zaramella M., Zicchetti M. Performance of real-time strain elastography, transient elastography, and aspartate-to-platelet ratio index in the assessment of fibrosis in chronic hepatitis C. AJR Am J Roentgenol 2012, 199:19-25.
10. Fiorini E., Cipriano V., De Molo C., Righi S., Ainora M.E., Arcelli A., Bertusi C., Montanari M., Bianchi G., Serra C. Real-time elastography as a noninvasive technique for quantification of fibrosis in patients with chronic liver disease: Preliminary findings. J Ultrasound 2012, 15:220-225.
11. Friedrich-Rust M., Ong M.F., Herrmann E., Dries V., Samaras P., Zeuzem S., Sarrazin C. Real-time elastography for non-invasive assessment of liver fibrosis in chronic viral hepatitis. AJR Am J Roentgenol 2007, 188:758-764.
12. Friedrich-Rust M., Schwarz A., Ong M., Dries V., Schirmacher P., Herrmann E., Samaras P., Bojunga J., Bohle R.M., Zeuzem S., Sarrazin C. Real-time tissue elastography versus FibroScan for non-invasive assessment of liver fibrosis in chronic liver disease. Ultraschall Med 2009, 30:478-484.
13. Friedrich-Rust M., Wunder K., Kriener S., Sotoudeh F., Richter S., Bojunga J., Herrmann E., Poynard T., Dietrich C.F., Vermehren J., Zeuzem S., Sarrazin C. Liver fibrosis in viral hepatitis: Non-invasive assessment with acoustic radiation force impulse imaging versus transient elastography. Radiology 2009, 252:595-604.
14. Fujimoto K., Kato M., Kudo M., Yada N., Shiina T., Ueshima K., Yamada Y., Ishida T., Azuma M., Yamasaki M., Yamamoto K., Hayashi N., Takehara T. Novel image analysis method using ultrasound elastography for non-invasive evaluation of hepatic fibrosis in patients with chronic hepatitis C. Oncology 2013, 84(Suppl. 1):3-12.
15. Gheonea D.I., Sǎftoiu A., Ciurea T., Gorunescu F., Iordache S., Popescu G.L., Belciug S., Gorunescu M., Sǎndulescu L. Real-time sono-elastography in the diagnosis of diffuse liver diseases. World J Gastroenterol 2010, 16:1720-1726.
16. Gheorghe L., Iacob S., Gheorghe C. Real-time sonoelastography: A new application in the field of liver disease. J Gastrointest Liver Dis 2008, 17:469-474.
17. Gulizia R., Ferraioli G., Filice C. Open questions in the assessment of liver fibrosis using real-time elastography. AJR Am J Roentgenol 2008, 190:W370-W371. author reply W372-W373.
18. Havre R.F., Waage J.R., Gilja O.H., Odegaard S., Nesje L.B. Real-time elastography: Strain ratio measurements are influenced by the position of the reference area. Ultraschall Med 2011 June 10, [Epub ahead of print].
19. Hirooka M., Koizumi Y., Hiasa Y., Abe M., Ikeda Y., Matsuura B., Onji M. Hepatic elasticity in patients with ascites: Evaluation with real-time tissue elastography. AJR Am J Roentgenol 2011, 196:W766-W771.
20. Kanamoto M., Shimada M., Ikegami T., Uchiyama H., Imura S., Morine Y., Kanemura H., Arakawa Y., Nii A. Real time elastography for non-invasive diagnosis of liver fibrosis. J Hepatobiliary Pancreat Surg 2009, 16:463-467.
21. Koizumi Y., Hirooka M., Kisaka Y., Konishi I., Abe M., Murakami H., Matsuura B., Hiasa Y., Onji M. Liver fibrosis in patients with chronic hepatitis C: Non-invasive diagnosis by means of real-time tissue elastography-Establishment of the method for measurement. Radiology 2011, 258:610-617.
22. Morikawa H., Fukuda K., Kobayashi S., Fujii H., Iwai S., Enomoto M., Tamori A., Sakaguchi H., Kawada N. Real-time tissue elastography as a tool for the non-invasive assessment of liver stiffness in patients with chronic hepatitis C. J Gastroenterol 2011, 46:350-358.
23. Nightingale K., Soo M.S., Nightingale R., Trahey G. Acoustic radiation force impulse imaging: In vivo demonstration of clinical feasibility. Ultrasound Med Biol 2002, 28:227-235.
24. Ochi H., Hirooka M., Koizumi Y., Miyake T., Tokumoto Y., Soga Y., Tada F., Abe M., Hiasa Y., Onji M. Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in non-alcoholic fatty liver diseases. Hepatology 2012, 56:1271-1278.
25. Orlacchio A., Bolacchi F., Antonicoli M., Coco I., Costanzo E., Tosti D., Francioso S., Angelico M., Simonetti G. Liver elasticity in NASH patients evaluated with real-time elastography (RTE). Ultrasound Med Biol 2012, 38:537-544.
26. Paparo F., Cevasco L., Zefiro D., Biscaldi E., Bacigalupo L., Balocco M., Pongiglione M., Banderali S., Forni G.L., Rollandi G.A. Diagnostic value of real-time elastography in the assessment of hepatic fibrosis in patients with liver iron overload. Eur J Radiol 2013, 82:e755-e761.
27. Sãftoiu A., Gheonea D.I., Ciurea T. Hue histogram analysis of real-time elastography images for non-invasive assessment of liver fibrosis. AJR Am J Roentgenol 2007, 189:W232-W233.
28. Sandrin L, Oudry J, Bastard C, Fournier C, Miette V, Mueller S. Non-invasive assessment of liver fibrosis by vibration-controlled transient elastography (Fibroscan®). In: Takahashi H, ed. Liver biopsy. Rijeka: Intech, 2011. DOI: 10.5772/20729.
29. Sporea I., Sirli R.L. Hepatic elastography for the assessment of liver fibrosis-Present and future. Ultraschall Med 2012, 33:550-558.
30. Tanter M., Touboul D., Gennisson J.L., Bercoff J., Fink M. High-resolution quantitative imaging of cornea elasticity using supersonic shear imaging. IEEE Trans Med Imaging 2009, 28:1881-1893.
31. Tatsumi C., Kudo M., Ueshima K., Kitai S., Ishikawa E., Yada N., Hagiwara S., Inoue T., Minami Y., Chung H., Maekawa K., Fujimoto K., Kato M., Tonomura A., Mitake T., Shiina T. Non-invasive evaluation of hepatic fibrosis for type C chronic hepatitis. Intervirology 2010, 53:76-81.
32. Tatsumi C., Kudo M., Ueshima K., Kitai S., Takahashi S., Inoue T., Minami Y., Chung H., Maekawa K., Fujimoto K., Akiko T., Takeshi M. Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastography. Intervirology 2008, 51(Suppl. 1):27-33.
33. Tomeno W., Yoneda M., Imajo K., Suzuki K., Ogawa Y., Shinohara Y., Mawatari H., Fujita K., Shibata W., Kirikoshi H., Maeda S., Nakajima A., Saito S. Evaluation of the liver fibrosis index calculated by using real-time tissue elastography for the non-invasive assessment of liver fibrosis in chronic liver diseases. Hepatol Res 2013, 43:735-742.
34. Tsochatzis E.A., Gurusamy K.S., Ntaoula S., Cholongitas E., Davidson B.R., Burroughs A.K. Elastography for the diagnosis of severity of fibrosis in chronic liver disease: A meta-analysis of diagnostic accuracy. J Hepatol 2011, 54:650-659.
35. Wang J., Guo L., Shi X., Pan W., Bai Y., Ai H. Real-time elastography with a novel quantitative technology for assessment of liver fibrosis in chronic hepatitis B. Eur J Radiol 2012, 81:e31-e36.
36. Xie L., Chen X., Guo Q., Dong Y., Guang Y., Zhang X. Real-time elastography for diagnosis of liver fibrosis in chronic hepatitis B. J Ultrasound Med 2012, 31:1053-1060.
37. Yada N., Kudo M., Morikawa H., Fujimoto K., Kato M., Kawada N. Assessment of liver fibrosis with real-time tissue elastography in chronic viral hepatitis. Oncology 2013, 84(Suppl 1):13-20.