Expedient synthesis of peptides containing Nε- carboxymethyllysine

Synlett

Volumn 25, Issue 13, 2014, Pages 1835-1838

  Kamalov, Meder ^a,b   Yang, Sunghyun ^a   Harris, Paul W R ^a   Cooper, Garth J S ^b,c,d,e,f   Brimble, Margaret A ^a,b,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b MAURICE WILKINS CENTRE FOR MOLECULAR BIODISCOVERY   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

advanced glycation endproducts; peptides; protecting groups; solid phase synthesis

Indexed keywords

6 N CARBOXYMETHYLLYSINE; 9 FLUORENYLMETHYLOXYCARBONYL; ADVANCED GLYCATION END PRODUCT; REAGENT; RESIN; SYNTHETIC PEPTIDE; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; DEPROTECTION REACTION; GLYCATION; MOLECULAR PROBE; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PROCESS DESIGN; PROCESS DEVELOPMENT; PROTEIN DEGRADATION; PURIFICATION; SOLID PHASE SYNTHESIS; SOLVENT EFFECT;

EID: 84905562377     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0033-1378305     Document Type: Article

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18. 2 (30 min), then in DMF (10 min) and filtered. A solution of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (90 μL, 0.6 mmol, 6 equiv) and 2-mercaptoethanol (42 μL, 0.6 mmol, 6 equiv) in DMF (5 mL) was added in one portion and the mixture was shaken for 15 min, drained, and washed with DMF.