Tafenoquine at therapeutic concentrations does not prolong fridericia-corrected QT interval in healthy subjects

Journal of Clinical Pharmacology

Volumn 54, Issue 9, 2014, Pages 995-1005

  Green, Justin A ^a   Patel, Apurva K ^b   Patel, Bela R ^b   Hussaini, Azra ^c   Harrell, Emma J ^a   McDonald, Mirna J ^b   Carter, Nick ^a   Mohamed, Khadeeja ^a   Duparc, Stephan ^d   Miller, Ann K ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c PAREXEL INTERNATIONAL   (United States)

^d Health Technology and Facilities Planning Health Policy   (Switzerland)

Author keywords

anti malarial; cardiology; moxifloxacin; QT; tafenoquine

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BILIRUBIN GLUCURONIDE; CREATINE KINASE; CREATININE; HEMOGLOBIN; METHEMOGLOBIN; MOXIFLOXACIN; TAFENOQUINE; AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY MASS; CIRCADIAN RHYTHM; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EXPOSURE; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG SAFETY; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HEART DEPOLARIZATION; HEART REPOLARIZATION; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NAUSEA AND VOMITING; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PLACEBO EFFECT; PLASMODIUM VIVAX MALARIA; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION; URTICARIA; ADOLESCENT; BIOLOGICAL MODEL; BLOOD; CLINICAL TRIAL; DRUG EFFECTS; ELECTROCARDIOGRAPHY; HEART RATE; MIDDLE AGED; SINGLE BLIND PROCEDURE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AMINOQUINOLINES; ANTIMALARIALS; ELECTROCARDIOGRAPHY; FEMALE; HEALTHY VOLUNTEERS; HEART RATE; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84905501916     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1002/jcph.302     Document Type: Article

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