Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization

Molecular Pharmaceutics

Volumn 11, Issue 8, 2014, Pages 2845-2854

  Oh, Donghoon ^a   Nasrolahi Shirazi, Amir ^a,b   Northup, Kevin ^a   Sullivan, Brian ^a   Tiwari, Rakesh Kumar ^a,b   Bisoffi, Marco ^b   Parang, Keykavous ^a,b  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b CHAPMAN UNIVERSITY   (United States)

Author keywords

acylation; cyclic peptide; cyclization; drug delivery; polyarginine

Indexed keywords

6 CARBOXYFLUORESCEIN; ARGININE; CELL PENETRATING PEPTIDE; DODECANOYL R 5; DODECANOYL R 6; DRUG CARRIER; F' DODECANOYL R 5; HEXADECANOYL R 5; LAURIC ACID; OCTANOIC ACID; OCTANOYL R 5; PALMITIC ACID; PHOSPHOPEPTIDE; POLYARGININE; UNCLASSIFIED DRUG; W DODECANOYL R 5; 6-CARBOXYFLUORESCEIN; CYCLOPEPTIDE; FATTY ACID; FLUORESCEIN DERIVATIVE; PEPTIDE; PHOSPHOLIPID; TRYPTOPHAN;

ACYLATION; ARTICLE; CONTROLLED STUDY; CYCLIZATION; ENDOCYTOSIS; ENERGY DEPENDENT ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; INTERNALIZATION; OVARIAN CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN TRANSPORT; CELL MEMBRANE; CELL PROLIFERATION; CHEMISTRY; CONFOCAL MICROSCOPY; HEK293 CELL LINE; METABOLISM; OVARIAN NEOPLASMS; TUMOR CELL LINE;

ACYLATION; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CELL-PENETRATING PEPTIDES; CYCLIZATION; DRUG CARRIERS; ENDOCYTOSIS; FATTY ACIDS; FEMALE; FLUORESCEINS; HEK293 CELLS; HUMANS; MICROSCOPY, CONFOCAL; OVARIAN NEOPLASMS; PEPTIDES; PEPTIDES, CYCLIC; PHOSPHOLIPIDS; PHOSPHOPEPTIDES; TRYPTOPHAN;

EID: 84905472272     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500203e     Document Type: Article

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