Peak exercise oxygen uptake during and following long-duration spaceflight

Journal of Applied Physiology

Volumn 117, Issue 3, 2014, Pages 231-238

  Moore Jr , Alan D ^a   Downs, Meghan E ^b   Lee, Stuart M C ^a   Feiveson, Alan H ^c   Knudsen, Poul ^d   Ploutz Snyder, Lori ^e  

^a WYLE LABORATORIES   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c NASA JOHNSON SPACE CENTER   (United States)

^d Danish Aerospace Company   (Denmark)

^e UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

Author keywords

Aerobic capacity; International Space Station; Weightlessness

Indexed keywords

OXYGEN;

COSMONAUT; EXERCISE; FEMALE; HEART RATE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; SPACE FLIGHT; TIME; WEIGHTLESSNESS;

ASTRONAUTS; EXERCISE; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; OXYGEN; SPACE FLIGHT; TIME FACTORS; WEIGHTLESSNESS;

EID: 84905456959     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01251.2013     Document Type: Article

References (48)

1. Abdullah SM, Hastings JL, Shibata S, Platts SH, Hamilton DR, Thomas JD, Hughes DE, Bungo MW, Levine BL. Effects of prolonged space flight on cardiac structure and function (Abstract). Circulation 128:A18672, 2013.
2. Alfrey CP, Udden MM, Huntoon CL, Driscoll T. Destruction of newly released red blood cells in space flight. Med Sci Sports Exercise 28:S42-S44, 1996.
3. Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T, Pickett MH. Control of red blood cell mass in spaceflight. J Appl Physiol 81:98-104, 1996.
4. Bassett DR Jr, Howley ET. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exercise 32:70-84, 2000.
5. Bonne TC, Doucende G, Fluck D, Jacobs RA, Nordsborg NB, Robach P, Walther G, Lundby C. Phlebotomy eliminates the maximal cardiac output response to six weeks of exercise training. Am J Physiol Regul Integr Comp Physiol 306:R752-R760, 2014.
6. Buderer MC, Rummel JA, Michel EL, Mauldin DG, Sawin CF. Exercise cardiac output following Skylab missions: the second manned Skylab mission. Aviation Space Environ Med 47:365-372, 1976.
7. Clemensen P, Christensen P, Norsk P, Gronlund J. A modified photoand magnetoacoustic multigas analyzer applied in gas exchange measurements. J Appl Physiol 76:2832-2839, 1994.
8. Cnaan A, Laird NM, Slasor P. Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Stat Med 16:2349-2380, 1997.
9. Convertino V, Hung J, Goldwater D, De Busk RF. Cardiovascular responses to exercise in middle-Aged men after 10 days of bedrest. Circulation 65:134-140, 1982.
10. Convertino VA. Cardiovascular consequences of bed rest: effect on maximal oxygen uptake. Med Sci Sports Exercise 29:191-196, 1997.
11. 2 kinetics of constantload exercise following bed-rest-induced deconditioning. J Appl Physiol 57:1545-1550, 1984.
12. Convertino VA, Kirby CR, Karst GM, Goldwater DJ. Response to muscular exercise following repeated simulated weightlessness. Aviation Space Environ Med 56:540-546, 1985.
13. Coyle EF, Hemmert MK, Coggan AR. Effects of detraining on cardiovascular responses to exercise: role of blood volume. J Appl Physiol 60:95-99, 1986.
14. 2 during exercise in humans: the peak vs. maximum issue. J Appl Physiol 95:1901-1907, 2003.
15. Dorfman TA, Levine BD, Tillery T, Peshock RM, Hastings JL, Schneider SM, Macias BR, Biolo G, Hargens AR. Cardiac atrophy in women following bed rest. J Appl Physiol 103:8-16, 2007.
16. Dorfman TA, Rosen BD, Perhonen MA, Tillery T, McColl R, Peshock RM, Levine BD. Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting. J Appl Physiol 104:1037-1044, 2008.
17. Evans H L J, Ferrar KE, Smith AE, Parfitt G, Eston RG. A systematic review of methods to predict maximal oxygen uptake from submaximal open circuit spirometry in healthy adults.. J Sci Med Sport In press.
18. Greene WH. Instrumental variables. In: Econometric Analysis. Upper Saddle River, NJ: Prentice Hall, 2000, p. 370-387.
19. Hastings JL, Krainski F, Snell PG, Pacini EL, Jain M, Bhella PS, Shibata S, Fu Q, Palmer MD, Levine BD. Effect of rowing ergometry and oral volume loading on cardiovascular structure and function during bed rest. J Appl Physiol 112:1735-1743, 2012.
20. Hochberg Y. A sharper Bonferroni procedure for multiple tests of significance. Biometrika 75:800-802, 1998.
21. Hung J, Goldwater D, Convertino VA, McKillop JH, Goris ML, De Busk RF. Mechanisms for decreased exercise capacity after bed rest in normal middle-Aged men. Am J Cardiol 51:344-348, 1983.
22. Jensen K, Jorgensen S, Johansen L. A metabolic cart for measurement of oxygen uptake during human exercise using inspiratory flow rate. Eur J Appl Physiol 87:202-206, 2002.
23. Lee SM, Schneider SM, Boda WL, Watenpaugh DE, Macias BR, Meyer RS, Hargens AR. Supine LBNP exercise maintains exercise capacity in male twins during 30-d bed rest. Med Sci Sports Exercise 39:1315-1326, 2007.
24. 2max: what do we know, and what do we still need to know? J Physiol 586:25-34, 2008.
25. Levine BD, Lane LD, Watenpaugh DE, Gaffney FA, Buckey JC, Blomqvist CG. Maximal exercise performance after adaptation to microgravity. J Appl Physiol 81:686-694, 1996.
26. Levine BD, Zuckerman JH, Pawelczyk JA. Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96:517-525, 1997.
27. Martin DS, South DA, Wood ML, Bungo MW, Meck JV. Comparison of echocardiographic changes after short- and long-duration spaceflight. Aviation Space Environ Med 73:532-536, 2002.
28. Michel EL, Rummel JA, Sawin CF. Skylab experiment M-171 "Metabolic Activity"-results of the first manned mission. Acta Astronautica 2:351-365, 1975.
29. Michel EL, Rummel JA, Sawin CF, Buderer MC, Lem JD. Results of Skylab Medical Experiment M171-Metabolic Activity. In: Biomedical Results from Skylab NASA SP-377. Washington, DC: Scientific and Technical Information Office, 1977.
30. Moore AD Jr, Lee SM, Charles JB, Greenisen MC, Schneider SM. Maximal exercise as a countermeasure to orthostatic intolerance after spaceflight. Med Sci Sports Exercise 33:75-80, 2001.
31. Moore AD, Lee S M C, Stenger MB, Platts SH. Cardiovascular exercise in the U. S space program: Past, present, and future. Acta Astonautica 66:974-988, 2010.
32. Pecatello LS, Arena R, Riebe D, Thompson P. ACSM's Guidelines for Exercise Testing and Prescription. Baltimore, MD: 2013.
33. Perhonen MA, Franco F, Lane LD, Buckey JC, Blomqvist CG, Zerwekh JE, Peshock RM, Weatherall PT, Levine BD. Cardiac atrophy after bed rest and spaceflight. J Appl Physiol 91:645-653, 2001.
34. Popov DV, Khusnutdinova DR, Shenkman BS, Vinogradova OL, Kozlovskaya IB. Dynamics of physical performance during long-duration space flight (first results of "Countermeasure" experiment). J Grav Physiol 11:P231-P232, 2004.
35. Ray CA, Cureton KJ. Interactive effects of body posture and exercise training on maximal oxygen uptake. J Appl Physiol 71:596-600, 1991.
36. Ray CA, Cureton KJ, Ouzts HG. Postural specificity of cardiovascular adaptations to exercise training. J Appl Physiol 69:2202-2208, 1990.
37. Rummel JA, Michel EL, Sawin CF, Buderer MC. Medical experiment M-171: results from the second manned Skylab mission. Aviation Space Environ Med 47:1056-1060, 1976.
38. 2pk during bed rest. Med Sci Sports Exercise 41:2165-2176, 2009.
39. Shibata S, Hastings JL, Abdullah SM, Bungo MW, Platts S, Hamilton DR, Levine BD. Determinants of cardiac loading during long duration spaceflight (Abstract). Circulation 128:A18500, 2013.
40. Shibata S, Perhonen M, Levine BD. Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest. J Appl Physiol 108:1177-1186, 2010.
41. Smith SM. Red blood cell and iron metabolism during space flight. Nutrition 18:864-866, 2002.
42. Smith SM, Heer MA, Shackelford LC, Sibonga JD, Ploutz-Snyder L, Zwart SR. Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: evidence from biochemistry and densitometry. J Bone Miner Res 27:1896-1906, 2012.
43. Sundblad P, Spaak J, Linnarsson D. Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (<6 degrees). Eur J Appl Physiol 83:303-309, 2000.
44. Trappe S, Costill D, Gallagher P, Creer A, Peters JR, Evans H, Riley DA, Fitts RH. Exercise in space: human skeletal muscle after 6 months aboard the International Space Station. J Appl Physiol 106:1159-1168, 2009.
45. Trappe T, Trappe S, Lee G, Widrick J, Fitts R, Costill D. Cardiorespiratory responses to physical work during and following 17 days of bed rest and spaceflight. J Appl Physiol 100:951-957, 2006.
46. Watenpaugh DE, Ballard RE, Schneider SM, Lee SM, Ertl AC, William JM, Boda WL, Hutchinson KJ, Hargens AR. Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity. J Appl Physiol 89:218-227, 2000.
47. Williams D, Kuipers A, Mukai C, Thirsk R. Acclimation during space flight: effects on human physiology. Can Med Assoc J 180:1317-1323, 2009.
48. 2 in man. J Appl Physiol 35:85-89, 1973.