Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest

Journal of Applied Physiology

Volumn 108, Issue 5, 2010, Pages 1177-1186

  Shibata, Shigeki ^a   Perhonen, Merja ^a   Levine, Benjamin D ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bed rest deconditioning; Cardiac function; Exercise; Orthostatic tolerance; Volume infusion

Indexed keywords

DEXTRAN; PLASMA SUBSTITUTE;

ARTICLE; ATROPHY; BED REST; BICYCLE; BLOOD VOLUME; BODY POSTURE; CARDIOVASCULAR EFFECT; CLINICAL TRIAL; COMPLIANCE (PHYSICAL); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART VENTRICLE PRESSURE; HEMODYNAMICS; HUMAN; HYPOVOLEMIA; INTRAVENOUS DRUG ADMINISTRATION; LOWER BODY NEGATIVE PRESSURE; MALE; MULTIMODALITY CANCER THERAPY; ORTHOSTATIC INTOLERANCE; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SUPINE POSITION; TIME; TREATMENT OUTCOME;

ATROPHY; BED REST; BICYCLING; BLOOD VOLUME; CARDIOVASCULAR DECONDITIONING; COMBINED MODALITY THERAPY; COMPLIANCE; DEXTRANS; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEAD-DOWN TILT; HEMODYNAMICS; HUMANS; HYPOVOLEMIA; INFUSIONS, INTRAVENOUS; LOWER BODY NEGATIVE PRESSURE; MALE; MYOCARDIUM; ORTHOSTATIC INTOLERANCE; PLASMA SUBSTITUTES; SUPINE POSITION; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 77951964310     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01408.2009     Document Type: Article

References (42)

1. Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thomas JD, Palmer D, Levine BD. Effect of aging and physical activity on left ventricular compliance. Circulation 110: 1799 - 1805, 2004.
2. Blomqvist C, Stone H. Cardiovascular adjustments to gravitational stress. In: Handbook of Physiology. The Cardiovascular System. Bethesda, MD: Am Physiol Soc, 1983, sect. 2, vol.III, pt. 2, p. 1025-1063.
3. Buckey JC Jr, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, Blomqvist CG. Orthostatic intolerance after spaceflight. J Appl Physiol 81: 7-18, 1996.
4. Bungo MW, Charles JB, Johnson PC Jr. Cardiovascular deconditioning during space flight and the use of saline as a countermeasure to orthostatic intolerance. Aviat Space Environ Med 56: 985-990, 1985.
5. Connolly D, Kirklin J, Wood E. The relationship between pulmonary artery wedge pressure and left atrial pressure in man. Circ Res 2: 434-440, 1954.
6. 6. Convertino VA. Blood volume response to physical activity and inactivity. Am J Med Sci 334: 72-79, 2007. (Pubitemid 47067450)
7. 7. Convertino VA, Engelke KA, Ludwig DA, Doerr DF. Restoration of plasma volume after 16 days of head-down tilt induced by a single bout of maximal exercise. Am J Physiol Regul Integr Comp Physiol 270: R3-R.10, 1996. (Pubitemid 26062526)
8. 8. de Groot PC, van Dijk A, Dijk E, Hopman MT. Preserved cardiac function after chronic spinal cord injury. Arch Phys Med Rehabil 87: 1195-1200, 2006. (Pubitemid 44277951)
9. 9. Dorfman TA, Levine BD, Tillen- T, Peshock RM, Hastings JL, Schneider SM, Macias BR, Biolo G, Hargens AR. Cardiac atrophy in women following bed rest. J Appl Physiol 103: 8-16, 2007. (Pubitemid 47092271)
10. 10. Dorfman TA, Rosen BD, Perhonen MA, Tillery T, McColl R, Peshock RM, Levine BD. Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting. J Appl Physiol 104: 1037-1044, 2008. (Pubitemid 351507942)
11. 11. Engelke KA, Doerr DF, Crandall CG, Convertino VA. Application of acute maximal exercise to protect orthostatic tolerance after simulated microgravity. Am J Physiol Regul Integr Comp Physiol. 271: R837-R847, 1996. (Pubitemid 126757859)
12. Foldager N, Blomqvist CG. Repeated plasma volume determination with the Evans Blue dye dilution technique: the method and a computer program. Comput Biol Med 21: 35-41, 1991.
13. Fu Q, Witkowski S, Levine BD. Vasoconstrictor reserve and sympathetic neural control of orthostasis. Circulation 110: 2931-2937, 2004.
14. Gaffney FA, Buckey JC, Lane LD, Hillebrecht A, Schulz H, Meyer M, Baisch F, Beck L, Heer M, Maass H, Arbeille P, Patat F, Blomqvist CG. The effects of a 10-day period of head-down tilt on the cardiovascular responses to intravenous saline loading. Acta Physiol Scand 604: 121-130, 1992.
15. Greenleaf JE, Bernauer EM, Ertl AC, Trowbridge TS, Wade CE. Work capacity during 30 days of bed rest with isotonic and isokinetic exercise training. J Appl Physiol 67: 1820-1826, 1989.
16. Greenleaf JE, Vernikos J, Wade CE, Barnes PR. Effect of leg exercise training on vascular volumes during 30 days of 6 degrees head-down bed rest. J Appl Physiol 72: 1887-1894, 1992.
17. 17. Greenleaf JE, Wade CE, Leftheriotis G. Orthostatic responses following 30-day bed rest deconditioning with isotonic and isokinetic exercise training. Aviat Space Environ Med 60: 537-542, 1989. (Pubitemid 19150959)
18. Guinet P, Schneider SM, Macias BR, Watenpaugh DE, Hughson RL, Le Traon AP, Bansard JY, Hargens AR. WISE-2005: effect of aerobic and resistive exercises on orthostatic tolerance during 60 days bed rest in women. Eur J Appl Physiol 106: 217-227, 2009.
19. Hundley WG, Li HF, Willard JE, Landau C, Lange RA, Meshack BM, Hillis LD, Peshock RM. Magnetic resonance imaging assessment of the severity of mitral regurgitation. Comparison with invasive techniques. Circulation 92: 1151-1158, 1995.
20. 20. Jarvis SS, Levine BD, Prisk GK, Shykoff BE, Elliott AR, Rosow E, Blomqvist CG, Pawelczyk JA. Simultaneous determination of the accuracy and precision of closed-circuit cardiac output rebreathing techniques. J Appl Physiol 103: 867-874, 2007. (Pubitemid 47358869)
21. 21. Katayama K, Sato K, Akima H, Ishida K, Takada H, Watanabe Y, Iwase M, Miyamura M, Iwase S. Acceleration with exercise during head-down bed rest preserves upright exercise responses. Aviat Space Environ Med 75: 1029-1035, 2004. (Pubitemid 39602159)
22. Katz J, Milliken MC, Stray-Gundersen J, Buja LM, Parkey RW, Mitchell JH, Peshock RM. Estimation of human myocardial mass with MR imaging. Radiology 169: 495-498, 1988.
23. Kimmerly DS, Shoemaker JK. Hypovolemia and neurovascular control during orthostatic stress. Am J Physiol Heart Circ Physiol 282: H645-H655, 2002.
24. Levine BD. Lower body negative pressure vs. lower body positive pressure to prevent cardiac atrophy after bed rest and spaceflight. What caused the controversy? (Author reply). J Appl Physiol 100: 1091-1092, 2006.
25. Levine BD, Lane LD, Buckey JC, Friedman DB, Blomqvist CG. Left ventricular pressure-volume and Frank-Starling relations in endurance athletes. Implications for orthostatic tolerance and exercise performance. Circulations: 1016-1023, 1991.
26. Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC Jr. Cooke WH, Baisch FJ, Eckberg DL, and Blomqvist CG. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J Physiol 538: 331-340, 2002.
27. Levine BD, Zuckerman JH, Pawelczyk JA. Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96: 517-525, 1997.
28. Nikolic S, Yellin EL, Tamura K, Vetter H, Tamura T, Meisner JS, Frater RW. Passive properties of canine left ventricle: diastolic stiffness and restoring forces. Circ Res 62: 1210-1222, 1988.
29. Noble MI. The Frank-Starling curve. Clin Sci Mol Med 54: 1-7, 1978.
30. Norsk P, Drummer C, Rocker L, Strollo F, Christensen NJ, Warberg J, Bie P, Stadeager C, Johansen LB, Heer M, Gunga HC, Gerzer R. Renal and endocrine responses in humans to isotonic saline infusion during microgravity. J Appl Physiol 78: 2253-2259, 1995.
31. 31. Perhonen MA, Franco F, Lane LD, Buckey JC, Blomqvist CG, Zerwekh JE, Peshock RM, Weatherall PT, Levine BD. Cardiac atrophy after bed rest and spaceflight. J Appl Physiol 91: 645-653, 2001. (Pubitemid 32681093)
32. Perhonen MA, Zuckerman JH, Levine BD. Deterioration of left ventricular chamber performance after bed rest: "cardiovascular deconditioning" or hypovolemia? Circulation 103: 1851-1857, 2001.
33. Sagawa K, Maughan L, Suga H, Sunagawa K. Physiological determinants of the ventricular pressure-volume relationship. In: Cardiac Contraction and Pressure. New York: Oxford Univ. Press, 1988, p. 110-170.
34. Saltin B, Blomqvist G, Mitchell JH, Johnson RL Jr, Wildenthal K, Chapman CB. Response to exercise after bed rest and after training. Circulation 38: VII1-VII78, 1968.
35. Scharhag J, Schneider G, Urhausen A, Rochette V, Kramann B, Kindermann W. Athlete's heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging. J Am Coll Cardiol 40: 1856-1863, 2002.
36. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I, Silverman NH, Tajik AJ. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of TwoDimensional Echocardiograms. J Am Soc. Echocardiogr 2: 358-367, 1989.
37. Schneider SM, Lee SM, Macias BR, Watenpaugh DE, Hargens AR. WISE-2005: exercise and nutrition countermeasures for upright V02pk during bed rest. Med Sci Sports Exerc 41: 2165-2176, 2009.
38. Stremel RW, Convertino VA, Bernauer EM, Greenleaf JE. Cardiorespiratory deconditioning with static and dynamic leg exercise during bed rest. J Appl Physiol 41: 905-909, 1976.
39. Tyberg JV, Taichman GC, Smith ER, Douglas NW, Smiseth OA, Keon WJ. The relationship between pericardial pressure and right atrial pressure: an intraoperative study. Circulation 73: 428-432, 1986.
40. 40. Watenpaugh DE, Ballard RE, Schneider SM, Lee SM, Ertl AC, William JM, Boda WL, Hutchinson KJ, Hargens AR. Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity. J Appl Physiol. 89: 218-227, 2000. (Pubitemid 30482583)
41. Watenpaugh DE, O'Leary DD, Schneider SM, Lee SM, Macias BR, Tanaka K, Hughson RL, Hargens AR. Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance. J Appl Physiol 103: 1964-1972, 2007.
42. 42. Yellin EL, Nikolic S, Frater RW. Left ventricular filling dynamics and diastolic function. Prog Cardiovasc Dis 32: 247-271, 1990. (Pubitemid 20038549)