Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability

Journal of Cell Science

Volumn 127, Issue 15, 2014, Pages 3294-3308

  Vagin, Olga ^a   Tokhtaeva, Elmira ^a   Garay, Patton E ^b   Souda, Puneet ^c   Bassilian, Sara ^a   Whitelegge, Julian P ^c   Lewis, Ramilla ^b   Sachs, George ^a   Wheeler, Larry ^b   Aoki, Roger ^b   Fernandez Salas, Ester ^b,d  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b ALLERGAN INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Botulinum toxin A protease; Degradation; Protein stability; Septin; Ubiquitylation

Indexed keywords

BOTULINUM TOXIN A; CARBANILAMIDE DERIVATIVE; CELL CYCLE PROTEIN; N-(2-CHLORO-4-PYRIDYL)-N'-PHENYLUREA; PROTEIN BINDING; PYRIDINE DERIVATIVE; SEPT7 PROTEIN, HUMAN; SEPTIN; SEPTIN 2 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL; CELL MEMBRANE; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MOUSE; MUTATION; NERVE CELL; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN TRANSPORT; TOXICITY AND INTOXICATION; TUMOR CELL LINE;

ANIMALS; BOTULINUM TOXINS, TYPE A; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; MICE; MUTATION; NEURONS; NEUROTOXICITY SYNDROMES; PHENYLUREA COMPOUNDS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN TRANSPORT; PYRIDINES; RNA, SMALL INTERFERING; SEPTINS;

EID: 84905454950     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.146324     Document Type: Article

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