Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115)

Developmental and Comparative Immunology

Volumn 47, Issue 1, 2014, Pages 123-128

  Moffat, L ^a   Rothwell, L ^a   Garcia Morales, C ^a   Sauter, K A ^a   Kapetanovic, R ^a,b   Gow, D J ^a   Hume, D A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

CSF1R; Monoclonal antibodies; Porcine

Indexed keywords

ANTIGEN; CD14 ANTIGEN; COLONY STIMULATING FACTOR RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD115; MONOCLONAL ANTIBODY ROS3A5; MONOCLONAL ANTIBODY ROS3B10; MONOCLONAL ANTIBODY ROS8G11; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL SURFACE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOCYTOCHEMISTRY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SWINE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHO CELL LINE; CRICETULUS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CHO CELLS; CRICETULUS; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; SUS SCROFA;

EID: 84905403907     PISSN: 0145305X     EISSN: 18790089     Source Type: Journal    
DOI: 10.1016/j.dci.2014.07.001     Document Type: Article

References (31)

1. Akcora D., Huynh D., Lightowler S., Germann M., Robine S., de May J.R., Pollard J.W., Stanley E.R., Malaterre J., Ramsay R.G. The CSF-1 receptor fashions the intestinal stem cell niche. Stem Cell Res. 2013, 10:203-212.
2. Ashmun R.A., Look A.T., Roberts W.M., Roussel M.F., Seremetis S., Ohtsuka M., Sherr C.J. Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells. Blood 1989, 73:827-837.
3. Auffray C., Fogg D.K., Narni-Mancinelli E., Senechal B., Trouillet C., Saederup N., Leemput J., Bigot K., Campisi L., Abitbol M., Molina T., Charo I., Hume D.A., Cumano A., Lauvau G., Geissmann F. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J. Exp. Med. 2009, 206:595-606.
4. Chihara T., Suzu S., Hassan R., Chutiwitoonchai N., Hiyoshi M., Motoyoshi K., Kimura F., Okada S. IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation. Cell Death Differ. 2010, 17:1917-1927.
5. Fairbairn L., Kapetanovic R., Sester D.P., Hume D.A. The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. J. Leukoc. Biol. 2011, 89:855-871.
6. Garceau V., Smith J., Paton I.R., Davey M., Fares M.A., Sester D.P., Burt D.W., Hume D.A. Pivotal advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products. J. Leukoc. Biol. 2010, 87:753-764.
7. Garcia-Morales C., Rothwell L., Moffat L., Garceau V., Balic A., Sang H.M., Kaiser P., Hume D.A. Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells. Dev. Comp. Immunol. 2013.
8. Gow D.J., Garceau V., Kapetanovic R., Sester D.P., Fici G.J., Shelly J.A., Wilson T.L., Hume D.A. Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34. Cytokine 2012, 60:793-805.
9. Groenen M.A., Archibald A.L., Uenishi H., Tuggle C.K., Takeuchi Y., Rothschild M.F., Rogel-Gaillard C., Park C., Milan D., Megens H.J., Li S., Larkin D.M., Kim H., Frantz L.A., Caccamo M., Ahn H., Aken B.L., Anselmo A., Anthon C., Auvil L., Badaoui B., Beattie C.W., Bendixen C., Berman D., Blecha F., Blomberg J., Bolund L., Bosse M., Botti S., Bujie Z., Bystrom M., Capitanu B., Carvalho-Silva D., Chardon P., Chen C., Cheng R., Choi S.H., Chow W., Clark R.C., Clee C., Crooijmans R.P., Dawson H.D., Dehais P., de Sapio F., Dibbits B., Drou N., Du Z.Q., Eversole K., Fadista J., Fairley S., Faraut T., Faulkner G.J., Fowler K.E., Fredholm M., Fritz E., Gilbert J.G., Giuffra E., Gorodkin J., Griffin D.K., Harrow J.L., Hayward A., Howe K., Hu Z.L., Humphray S.J., Hunt T., Hornshoj H., Jeon J.T., Jern P., Jones M., Jurka J., Kanamori H., Kapetanovic R., Kim J., Kim J.H., Kim K.W., Kim T.H., Larson G., Lee K., Lee K.T., Leggett R., Lewin H.A., Li Y., Liu W., Loveland J.E., Lu Y., Lunney J.K., Ma J., Madsen O., Mann K., Matthews L., McLaren S., Morozumi T., Murtaugh M.P., Narayan J., Nguyen D.T., Ni P., Oh S.J., Onteru S., Panitz F., Park E.W., et al. Analyses of pig genomes provide insight into porcine demography and evolution. Nature 2012, 491:393-398.
10. Hettinger J., Richards D.M., Hansson J., Barra M.M., Joschko A.C., Krijgsveld J., Feuerer M. Origin of monocytes and macrophages in a committed progenitor. Nat. Immunol. 2013, 14:821-830.
11. Hume D.A. The mononuclear phagocyte system. Curr. Opin. Immunol. 2006, 18:49-53.
12. Hume D.A., Macdonald K.P. Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood 2012, 119:1810-1820.
13. Hume D.A., Ross I.L., Himes S.R., Sasmono R.T., Wells C.A., Ravasi T. The mononuclear phagocyte system revisited. J. Leukoc. Biol. 2002, 72:621-627.
14. Ingersoll M.A., Spanbroek R., Lottaz C., Gautier E.L., Frankenberger M., Hoffmann R., Lang R., Haniffa M., Collin M., Tacke F., Habenicht A.J., Ziegler-Heitbrock L., Randolph G.J. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 2010, 115:e10-e19.
15. Kapetanovic R., Fairbairn L., Beraldi D., Sester D.P., Archibald A.L., Tuggle C.K., Hume D.A. Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide. J. Immunol. 2012, 188:3382-3394.
16. Kapetanovic R., Fairbairn L., Downing A., Beraldi D., Sester D.P., Freeman T.C., Tuggle C.K., Archibald A.L., Hume D.A. The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide. BMC Genomics 2013, 14:581.
17. Karasuyama H., Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 1988, 18:97-104.
18. Macdonald K.P., Palmer J.S., Cronau S., Seppanen E., Olver S., Raffelt N.C., Kuns R., Pettit A.R., Clouston A., Wainwright B., Branstetter D., Smith J., Paxton R.J., Cerretti D.P., Bonham L., Hill G.R., Hume D.A. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood 2010, 116:3955-3963.
19. Perez C., Moreno S., Summerfield A., Domenech N., Alvarez B., Correa C., Alonso F., Ezquerra A., Dominguez J., Revilla C. Characterisation of porcine bone marrow progenitor cells identified by the anti-c-kit (CD117) monoclonal antibody 2B8/BM. J. Immunol. Methods 2007, 321:70-79.
20. Rae F., Woods K., Sasmono T., Campanale N., Taylor D., Ovchinnikov D.A., Grimmond S.M., Hume D.A., Ricardo S.D., Little M.H. Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Dev. Biol. 2007, 308:232-246.
21. Rothwell L., Hamblin A., Kaiser P. Production and characterisation of monoclonal antibodies specific for chicken interleukin-2. Vet. Immunol. Immunopathol. 2001, 83:149-160.
22. Sasmono R.T., Ehrnsperger A., Cronau S.L., Ravasi T., Kandane R., Hickey M.J., Cook A.D., Himes S.R., Hamilton J.A., Hume D.A. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J. Leukoc. Biol. 2007, 82:111-123.
23. Sasmono R.T., Oceandy D., Pollard J.W., Tong W., Pavli P., Wainwright B.J., Ostrowski M.C., Himes S.R., Hume D.A. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 2003, 101:1155-1163.
24. Schroder K., Irvine K.M., Taylor M.S., Bokil N.J., le Cao K.A., Masterman K.A., Labzin L.I., Semple C.A., Kapetanovic R., Fairbairn L., Akalin A., Faulkner G.J., Baillie J.K., Gongora M., Daub C.O., Kawaji H., McLachlan G.J., Goldman N., Grimmond S.M., Carninci P., Suzuki H., Hayashizaki Y., Lenhard B., Hume D.A., Sweet M.J. Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proc. Natl. Acad. Sci. USA 2012, 109:E944-E953.
25. Seino J., Eveleigh P., Warnaar S., van Haarlem L.J., van Es L.A., Daha M.R. Activation of human complement by mouse and mouse/human chimeric monoclonal antibodies. Clin. Exp. Immunol. 1993, 94:291-296.
26. Seok J., Warren H.S., Cuenca A.G., Mindrinos M.N., Baker H.V., Xu W., Richards D.R., McDonald-Smith G.P., Gao H., Hennessy L., Finnerty C.C., Lopez C.M., Honari S., Moore E.E., Minei J.P., Cuschieri J., Bankey P.E., Johnson J.L., Sperry J., Nathens A.B., Billiar T.R., West M.A., Jeschke M.G., Klein M.B., Gamelli R.L., Gibran N.S., Brownstein B.H., Miller-Graziano C., Calvano S.E., Mason P.H., Cobb J.P., Rahme L.G., Lowry S.F., Maier R.V., Moldawer L.L., Herndon D.N., Davis R.W., Xiao W., Tompkins R.G. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA 2013, 110:3507-3512.
27. Sherr C.J., Rettenmier C.W. The fms gene and the CSF-1 receptor. Cancer Surv. 1986, 5:221-232.
28. Shulman M., Wilde C.D., Kohler G. A better cell line for making hybridomas secreting specific antibodies. Nature 1978, 276:269-270.
29. Stanley E.R., Chitu V. CSF-1 Receptor Signaling in Myeloid Cells. Cold Spring Harb. Perspect. Biol. 2014, 6.
30. Wei S., Nandi S., Chitu V., Yeung Y.G., Yu W., Huang M., Williams L.T., Lin H., Stanley E.R. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J. Leukoc. Biol. 2010, 88:495-505.
31. Yoshida S., Hoppe A.D., Araki N., Swanson J.A. Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages. J. Cell Sci. 2009, 122:3250-3261.