Antibodies to Toxoplasma gondii and cognitive functioning in schizophrenia, bipolar disorder, and nonpsychiatric controls

Journal of Nervous and Mental Disease

Volumn 202, Issue 8, 2014, Pages 589-593

  Dickerson, Faith ^a   Stallings, Cassie ^a   Origoni, Andrea ^a   Katsafanas, Emily ^a   Schweinfurth, Lucy ^a   Savage, Christina ^a   Khushalani, Sunil ^a   Yolken, Robert ^b  

^a SHEPPARD PRATT HEALTH SYSTEM   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

bipolar disorder; cognition; infection; parasite; Schizophrenia; Toxoplasma gondii

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PROTOZOON ANTIBODY;

ADULT; ARTICLE; ATTENTION; BIPOLAR DISORDER; COGNITION; CONTROLLED STUDY; EXPOSURE; FEMALE; HUMAN; LANGUAGE; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; NONHUMAN; SCHIZOPHRENIA; SCORING SYSTEM; SHORT TERM MEMORY; TOXOPLASMA GONDII;

ADULT; ANTIBODIES, PROTOZOAN; BIPOLAR DISORDER; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA; TOXOPLASMA; YOUNG ADULT;

EID: 84905391531     PISSN: 00223018     EISSN: 1539736X     Source Type: Journal    
DOI: 10.1097/NMD.0000000000000166     Document Type: Article

References (28)

1. Buchanan RW, Freedman R, Javitt DC, Abi-DarghamA, Lieberman JA (2007) Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia. Schizophr Bull. 33:1120-1130.
2. Coutinho SG, Leite M.A., Amendoeira MR, Marzochi MC (1982) Concomitant cases of acquired toxoplasmosis in children of a single family: Evidence of reinfection. J Infect Dis. 146:30-33.
3. Dickerson F, Stallings C, Origoni A, Vaughan C, Katsafanas E, Khushalani S, Yolken R (2014) Antibodies to Toxoplasma gondii in individuals with mania. Bipolar Disord. 16:129-136.
4. Dickerson F, Stallings C, Sullens A, Origoni A, Leister F, Krivogorsky B, Yolken R (2008) Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder. Brain Behav Immun. 22:1103-1107.
5. Dickerson FB, Boronow JJ, Stallings C, Origoni AE, Cole S, Krivogorsky B, Yolken RH (2004) Infection with herpes simplex virus type 1 is associated with cognitive deficits in bipolar disorder. Biol Psychiatry. 55:588-593.
6. Doggett JS, Nilsen A, Forquer I, Wegmann KW, Jones-Brando L, Yolken RH, Bordon C, Charman SA, Katneni K, Schultz T, Burrows JN, Hinrichs DJ, Meunier B, Carruthers VB, Riscoe MK (2012) Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 109:15936-15941.
7. First M, Gibbon M, Spitzer RL, Williams JBW (1996) Users Guide for the SCID-I, Structured Clinical Interview for DSM IVAxis I Disorders. NewYork:Biometrics Research.
8. First M, Gibbon M, Spitzer RL, Williams JBW (1998) Structured Clinical interview for DSM-IV Disorders, Non-Patient Edition. New York: Biometrics Research.
9. Gajewski PD, Falkenstein M, Hengstler JG, Golka K (2014) Toxoplasma gondii impairs memory in infected seniors. Brain Behav Immun. 36:193-199.
10. Hamdani N, Daban-Huard C, Lajnef M, Richard J.R., Delavest M, Godin O, Guen EL, Vederine FE, Lepine JP, Jamain S, Houenou J, Corvoisier PL, Aoki M, Moins-Teisserenc H, Charron D, Krishnamoorthy R, Yolken R, Dickerson F, Tamouza R, Leboyer M (2013) Relationship between Toxoplasma gondii infection and bipolar disorder in a French sample. J Affect Disord. 148:444-448.
11. Heinrichs RW, Zakzanis KK (1998) Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology. 12:426-445.
12. Henriquez FL, Woods S, Cong H, McLeod R, Roberts CW (2010) Immunogenetics of Toxoplasma gondii informs vaccine design. Trends Parasitol. 26:550-555.
13. Hill DE, Chirukandoth S, Dubey JP (2005) Biology and epidemiology of Toxoplasma gondii in man and animals. Anim Health Res Rev. 6:41-61.
14. Jones-Brando L, Torrey EF, Yolken R (2003) Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res. 62:237-244.
15. Kannan G, Pletnikov MV (2012) Toxoplasma gondii and cognitive deficits in schizophrenia: An animal model perspective. Schizophr Bull. 38:1155-1161.
16. Kay S.R., Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 13:261-276.
17. Kaye A (2011) Toxoplasmosis: Diagnosis, treatment, and prevention in congenitally exposed infants. J Pediatr Health Care. 25:355-364.
18. Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB (2010) The Schizophrenia Patient Outcomes Research Team (PORT): Updated treatment recommendations 2009. Schizophr Bull. 36:94-103.
19. Market E, Papavasiliou FN (2003) V(D)J recombination and the evolution of the adaptive immune system. PLoS Biol. 1:E16.
20. Martinez-Aran A, Vieta E, Colom F, Reinares M, Benabarre A, Gasto C, Salamero M (2000) Cognitive dysfunctions in bipolar disorder: Evidence of neuropsychological disturbances. Psychother Psychosom. 69:2-18.
21. Nimgaonkar VL, Yolken RH (2012) Neurotropic infectious agents and cognitive impairment in schizophrenia. Schizophr Bull. 38:1135-1136.
22. Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA (2011) The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PloS One. 6:e23866.
23. Randolph C, Tierney MC, Mohr E, Chase TN (1998) The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary clinical validity. J Clin Exp Neuropsychol. 20:310-319.
24. Robert-Gangneux F, Bourhis C, Chevrier S, Gangneux JP (2009) Evaluation of DPC immulite 2000 Toxoplasma quantitative IgG/IgM kits for automated toxoplasmosis serology with immulite 2000. J Clin Lab Anal. 23:336-340.
25. Torrey EF, Bartko JJ, Yolken RH (2012) Toxoplasma gondii and other risk factors for schizophrenia: An update. Schizophr Bull. 38:642-647.
26. van Gorp WG, Altshuler L, Theberge DC, Wilkins J, Dixon W (1998) Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study. Arch Gen Psychiatry. 55:41-46.
27. Wykes T, Spaulding WD (2011) Thinking about the future cognitive remediation therapyVWhat works and could we do better? Schizophr Bull. 37(suppl 2): S80YS90.
28. Xiao J, Kannan G, Jones-Brando L, Brannock C, Krasnova IN, Cadet JL, Pletnikov M, Yolken RH (2012) Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice. Neuroscience. 206:39-48.