Verification of a parkinsons disease protein signature in T-lymphocytes by multiple reaction monitoring

Journal of Proteome Research

Volumn 13, Issue 8, 2014, Pages 3554-3561

  Alberio, Tiziana ^a   McMahon, Kelly ^b   Cuccurullo, Manuela ^b   Gethings, Lee A ^b   Lawless, Craig ^c   Zibetti, Maurizio ^d   Lopiano, Leonardo ^d   Vissers, Johannes P C ^b   Fasano, Mauro ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b WATERS CORPORATION   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

biomarkers; multiple reaction monitoring; Parkinsons disease; peripheral blood lymphocytes

Indexed keywords

BIOLOGICAL MARKER; LEVODOPA; MOESIN; PEPTIDE; PROTEIN; PROTEIN KINASE LCK; SEPTIN; TRANSALDOLASE; VIMENTIN; CYTOSKELETON PROTEIN;

ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MONITORING; MONONUCLEAR CELL; MULTIPLE REACTION MONITORING; PARKINSON DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; T LYMPHOCYTE; TWO DIMENSIONAL ELECTROPHORESIS; VALIDATION STUDY; AMINO ACID SEQUENCE; DIAGNOSTIC USE; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AMINO ACID SEQUENCE; AREA UNDER CURVE; BIOLOGICAL MARKERS; CYTOSKELETAL PROTEINS; DISCRIMINANT ANALYSIS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; MOLECULAR SEQUENCE DATA; PARKINSON DISEASE; PEPTIDES; T-LYMPHOCYTES;

EID: 84905386210     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr401142p     Document Type: Article

References (18)

1. Sharma, S.; Moon, C. S.; Khogali, A.; Haidous, A.; Chabenne, A.; Ojo, C.; Jelebinkov, M.; Kurdi, Y.; Ebadi, M. Biomarkers in Parkinsons disease (recent update) Neurochem. Int. 2013, 63 (3) 201-229
2. Jankovic, J. Parkinsons disease: clinical features and diagnosis J. Neurol. Neurosurg. Psychiatry 2008, 79 (4) 368-376
3. Shulman, J. M.; De Jager, P. L.; Feany, M. B. Parkinsons disease: genetics and pathogenesis Annu. Rev. Pathol. 2011, 6, 193-222
4. Morgan, J. C.; Mehta, S. H.; Sethi, K. D. Biomarkers in Parkinsons disease Curr. Neurol. Neurosci. Rep. 2010, 10 (6) 423-430
5. Alberio, T.; Fasano, M. Proteomics in Parkinsons disease: An unbiased approach towards peripheral biomarkers and new therapies J. Biotechnol. 2011, 156 (4) 325-337
6. Gerlach, M.; Maetzler, W.; Broich, K.; Hampel, H.; Rems, L.; Reum, T.; Riederer, P.; Stöffler, A.; Streffer, J.; Berg, D. Biomarker candidates of neurodegeneration in Parkinsons disease for the evaluation of disease-modifying therapeutics J. Neural Transm. 2012, 119 (1) 39-52
7. Marek, K.; Jennings, D.; Tamagnan, G.; Seibyl, J. Biomarkers for Parkinsons disease: Tools to assess Parkinsons disease onset and progression Ann. Neurol. 2008, 64 (S2) S111-S121
8. Caudle, W. M.; Bammler, T. K.; Lin, Y.; Pan, S.; Zhang, J. Using omics to define pathogenesis and biomarkers of Parkinsons disease Exp. Rev. Neurother. 2010, 10 (6) 925-942
9. Alberio, T.; Pippione, A. C.; Zibetti, M.; Olgiati, S.; Cecconi, D.; Comi, C.; Lopiano, L.; Fasano, M. Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinsons disease Sci. Rep. 2012, 2, 953
10. Alberio, T.; Fasano, M.; Lopiano, L. Method for the in vitro diagnosis of Parkinsons disease. WIPO Patent No. 2013098786; World Intellectual Property Organization: Geneva, Switzerland, 2013.
11. Surinova, S.; Schiess, R.; Hüttenhain, R.; Cerciello, F.; Wollscheid, B.; Aebersold, R. On the development of plasma protein biomarkers J. Proteome Res. 2010, 10 (1) 5-16
12. Hoofnagle, A. N.; Becker, J. O.; Oda, M. N.; Cavigiolio, G.; Mayer, P.; Vaisar, T. Multiple-Reaction Monitoring-Mass Spectrometric assays can accurately measure the relative protein abundance in complex mixtures Clin. Chem. 2012, 58 (4) 777-781
13. MacLean, B.; Tomazela, D. M.; Shulman, N.; Chambers, M.; Finney, G. L.; Frewen, B.; Kern, R.; Tabb, D. L.; Liebler, D. C.; MacCoss, M. J. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments Bioinformatics 2010, 26 (7) 966-968
14. Altschul, S. F.; Gish, W.; Miller, W.; Myers, E. W.; Lipman, D. J. Basic local alignment search tool J. Mol. Biol. 1990, 215 (3) 403-410
15. Reiter, L.; Rinner, O.; Picotti, P.; Hüttenhain, R.; Beck, M.; Brusniak, M. Y.; Hengartner, M. O.; Aebersold, R. mProphet: automated data processing and statistical validation for large-scale SRM experiments Nat. Methods 2011, 8 (5) 430-435
16. Fasano, M.; Alberio, T. An automated procedure for the statistical analysis of two-dimensional electrophoresis gels for biomarkers discovery Protoc. Exch. 2013, 10.1038/protex.2013.001
17. Fasano, M.; Alberio, T.; Lopiano, L. Peripheral biomarkers of Parkinsons disease as early reporters of central neurodegeneration Biomarkers Med. 2008, 2 (5) 465-478
18. Squillario, M.; Barla, A. A computational procedure for functional characterization of potential marker genes from molecular data: Alzheimers as a case study BMC Med. Genomics 2011, 4, 55 10.1186/1755-8794-4-55