Ethanolic extracts of Tinospora cordifolia and Alstonia scholaris show antimicrobial activity towards clinical isolates of methicillin-resistant and carbapenemase-producing bacteria

Natural Product Research

Volumn 28, Issue 18, 2014, Pages 1438-1445

  Bonvicini, Francesca ^a   Mandrone, Manuela ^a   Antognoni, Fabiana ^a   Poli, Ferruccio ^a   Gentilomi, Giovanna Angela ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Alstonia scholaris; antimicrobial activity; Ayurveda tradition; broth micro dilution; clinical isolates; multiple drug resistance pathogens; Tinospora cordifolia

Indexed keywords

ALCOHOL; ALSTONIA SCHOLARIS EXTRACT; AMPHOTERICIN B; GENTAMICIN; TINOSPORA CORDIFOLIA EXTRACT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE; PLANT EXTRACT;

ALSTONIA SCHOLARIS; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; AYURVEDA; BACTERIAL STRAIN; BACTERIUM ISOLATE; BROTH DILUTION; CANDIDA ALBICANS; CARBAPENEMASE PRODUCING KLEBSIELLA PNEUMONIAE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MAMMAL CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; TINOSPORA CORDIFOLIA; ALSTONIA; ANIMAL; BACTERIA; CAENORHABDITIS ELEGANS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FIBROBLAST; IC50; ISOLATION AND PURIFICATION; ITALY; METABOLISM; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; PENICILLIN RESISTANCE; TINOSPORA;

ALSTONIA SCHOLARIS; CANDIDA ALBICANS; CRATAEVA NURVALA; KLEBSIELLA PNEUMONIAE; MAMMALIA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; TINOSPORA CORDIFOLIA;

ALSTONIA; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; BACTERIA; BACTERIAL PROTEINS; BETA-LACTAMASES; CAENORHABDITIS ELEGANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; ETHANOL; FIBROBLASTS; HUMANS; INHIBITORY CONCENTRATION 50; ITALY; KLEBSIELLA PNEUMONIAE; MEDICINE, AYURVEDIC; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PLANT EXTRACTS; TINOSPORA;

EID: 84905380989     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2014.909421     Document Type: Article

References (25)

1. Ahmad VU, Fizza K, Amber AR, Arif S. 1987. Cadabicine and cadabicine diacetate from Crataeva nurvala and Cadaba farinosa. J Nat Prod. 50: 1186-1186.
2. Aranha I, Clement F, Venkatesh YP. 2012. Immunostimulatory properties of the major protein from the stem of the Ayurvedic medicinal herb, guduchi (Tinospora cordifolia). J Ethnopharmacol. 139:366-372.
3. Bopanna N, Saxena S. 2008. Crataeva nurvala: a valuable medicinal plant. J Herbs Spices Med Plants. 14:107-127.
4. Joshi SG. 2000. Crataeva nurvala Buch. Ham. In: Medicinal plants. Calcutta: Oxford and IBH Publishers Ltd; p. 127-128.
5. Kamarajan P, Sekar N, Mathuram V, Govindasamy S. 1991. Antitumor effect of echitamine chloride on methylcholonthrene induced fibrosarcoma in rats. Biochem Int. 25:491-496.
6. Khan M. 2003. Antibacterial activity of Alstonia scholaris and Leea tetramera. Fitoterapia. 74:736-740.
7. Koppada R, Norozian FM, Torbati D, Kalomiris S, Ramachandran C, Totapally BR. 2009. Physiological effects of a novel immune stimulator drug, (1,4)-alpha-D-glucan, in rats. Basic Clin Pharmacol Toxicol. 105:217-221.
8. Molly A, Shekhar MC, Thankamani V. 2014. Antibacterial activity of plant extracts of Alstonia scholaris. Int J Pharmacogn Phytochem Res. 5(4):285-291.
9. Mukherjee PK, Wahile A. 2006. Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol. 103:25-35.
10. Nadkarni KM, Nadkarni AK. 1976. Indian materia medica. 3rd ed. Mumbai: M/S Popular Prakasan Ltd.
11. National Committee for Clinical Laboratory Standards. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standards. Vol. 26(2). M7-A7. Wayne, PA: NCCLS.
12. Perry LM, Metzger J. 1980. Medicinal plants of East and Southeast Asia: attributed properties and uses. Cambridge (MA): MIT Press.
13. Rao PR, Kumar VK, Viswanath RK, Subbaraju GV. 2005. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol Pharmacol Bull. 28 (12):2319-2322.
14. Saha S, Ghosh S. 2012. Tinospora cordifolia: one plant, many roles. Anc Sci Life. 31:151-159.
15. Salim AA, Garson MJ, Craik DJ. 2004. New indole alkaloids from the bark of Alstonia scholaris. J Nat Prod. 67 (9):1591-1594.
16. Sangeetha MK, Balaji Raghavendran HR, Gayathri V, Vasanthi HR. 2011. Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats. Nat Med. 65(3-4): 544-550.
17. Satyavati GV, Gupta AK, Tandon N. 1987. Medicinal plants of India. Vol. 2. New Delhi: Cambridge Printing Works, Naraina Phase II.
18. Shah PM. 2005. The need for new therapeutic agents: what is in the pipeline? Clin Microbiol Infec. 11:36-42.
19. Shang JH, Cai XH, Feng T, Zhao YL, Wang JK, Zhang LY, Yan M, Luo XD. 2010. Pharmacological evaluation of Alstonia scholaris: anti-inflammatory and analgesic effects. J Ethnopharmacol. 129:174-181.
20. Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S. 2012. Immunomodulatory active compounds from Tinospora cordifolia. J Ethnopharmacol. 141:918-926.
21. Singh SS, Pandey SC, Srivastava S, Gupta VS, Patro B, Ghosh AC. 2003. Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Ind J Pharmacol. 35:83-91.
22. Sinha S, Mishra P, Amin H, Rah B, Nayak D, Goswami A, Kumar N, Vishwakarma R, Ghosal S. 2013. A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: study of antiproliferative and apoptosis inducing property. Eur J Med Chem. 60:490-496.
23. Tambekar DH, Khante BS, Chandak BR, Tltare AS, Boralkar SS, Aghadte SN. 2009. Screening of antibacterial potential of some medicinal plants from Melghat Forest in India. Afr J Trad Complement Altern Med. 6(3):228-232.
24. Wermuth CG. 2004. Multi targeted drugs: the end of the "one-target-one-disease" philosophy? Drug Discovery Today. 9:826-827.
25. Zuo GY, Zhang XJ, Yang CX, Han J, Wang GC, Bian ZQ. 2012. Evaluation of traditional Chinese medicinal plants for Anti-MRSA activity with reference to the treatment record of infectious diseases. Molecules. 17:2955-2967.