Polycystic Ovary syndrome: Update on diagnosis and treatment

American Journal of Medicine

Volumn 127, Issue 10, 2014, Pages 912-919

  Setji, Tracy L ^a   Brown, Ann J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hirsutism; Insulin resistance; Irregular menses; Oligomenorrhea; PCOS; Polycystic ovary syndrome; Treatment

Indexed keywords

AMINOTRANSFERASE; CLOMIFENE CITRATE; HEMOGLOBIN A1C; LIPID; METFORMIN; ORAL CONTRACEPTIVE AGENT;

ACNE; AMENORRHEA; DEPRESSION; DIABETES MELLITUS; EATING DISORDER; ENDOMETRIUM HYPERPLASIA; FATTY LIVER; FEMALE FERTILITY; FEMALE SUBFERTILITY; HEREDITY; HIRSUTISM; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; MALE TYPE ALOPECIA; MENSTRUAL CYCLE; METABOLIC SYNDROME X; MULTICENTER STUDY (TOPIC); OLIGOMENORRHEA; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; OVULATION; PATHOGENESIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SELF CARE; SLEEP DISORDERED BREATHING; ANOVULATION; COMPLICATION; DIET; EXERCISE; FEMALE; HEALTH BEHAVIOR; HYPERANDROGENISM; MENSTRUATION DISTURBANCES; METABOLIC DISEASES; PATHOPHYSIOLOGY; POLYCYSTIC OVARY SYNDROME; SLEEP APNEA SYNDROMES; WEIGHT REDUCTION;

ANOVULATION; CONTRACEPTIVES, ORAL, HORMONAL; DEPRESSION; DIET; EXERCISE; FEMALE; HEALTH BEHAVIOR; HIRSUTISM; HUMANS; HYPERANDROGENISM; HYPERTENSION; INSULIN RESISTANCE; MENSTRUATION DISTURBANCES; METABOLIC DISEASES; POLYCYSTIC OVARY SYNDROME; SLEEP APNEA SYNDROMES; WEIGHT LOSS;

EID: 84905255470     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2014.04.017     Document Type: Review

References (41)

1. T.L. Setji, and A.J. Brown Polycystic ovary syndrome and type 2 diabetes M.N. Feinglos, M.A. Bethel, Type 2 Diabetes Mellitus: An Evidence-Based Approach to Practical Management 2008 Human Press Totowa, NJ 377 390
2. J. Zawadzki, and A. Dunaif Diagnostic criteria for polycystic ovary syndrome: towards a rational approach A. Dunaif, J. Givens, F. Haseltine, G. Haseltine, Polycystic Ovary Syndrome 1st ed 1992 Blackwell Scientific Oxford, England 377 384
3. R. Azziz, E. Carmina, and D. Dewailly Task Force on the Phenotype of the Polycystic Ovary Syndrome of the Androgen Excess and PCOS Society The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report Fertil Steril 91 2009 456 488
4. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Hum Reprod 19 2004 41 47
5. S. Livadas, and E. Diamanti-Kandarakis Polycystic ovary syndrome: definitions, phenotypes, and diagnostic approach Front Horm Res 40 2013 1 21
6. NIH Evidence Based Methodology Workshop on Polycystic Ovary Syndrome. December 2012. Executive Summary. Available at: http://prevention.nih.gov/workshops/2012/pcos/docs/PCOS-Final-Statement.pdf. Accessed December 21, 2013.
7. R. Homburg, A. Ray, and P. Bhide The relationship of serum anti-Mullerian hormone and polycystic ovarian morphology and polycystic ovary syndrome: a prospective cohort study Hum Reprod 28 2013 1077 1083
8. M.O. Goodarzi, D.A. Dumesic, and Chazenbalk Polycystic ovary syndrome: etiology, pathogenesis and diagnosis Nat Rev 7 2011 219 231
9. E. Carmina, F. Rosato, and A. Janni Relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism J Clin Endocrinol Metab 91 2006 2 6
10. K.A. Martin, J. Chang, and D. Ehrmann Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline J Clin Endocrinol Metab 93 2008 1105 1120
11. R. Ness-Abramof, D. Nabriski, and C.M. Apovian Overnight dexamethasone suppression test: a reliable screen for Cushing's syndrome in the obese Obes Res 10 2002 1217 1221
12. R.S. Legro, A.R. Kunselman, and W.C. Dodson Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women J Clin Endocrinol Metab 84 1999 165 169
13. U. Ezeh, B.O. Yildiz, and R. Aziz Referral bias in defining the phenotype and prevalence of obesity in polycystic ovary syndrome J Clin Endocrinol Metab 98 2013 E1088 E1096
14. C.J. Glueck, R. Papanna, and P. Wang Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome Metabolism 52 2003 908 915
15. E. Carmina, and R. Azziz Diagnosis, phenotype and prevalence of polycystic ovary syndrome Fertil Steril 86 Suppl 1 2006 S7 S8
16. J.C. Lo, S.L. Feigenbaum, and J. Yang Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome J Clin Endocrinol Metab 91 2006 1357 1363
17. R.A. Wild, M. Rizzo, and S. Clifton Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis Fertil Steril 95 2011 1073 1079
18. T.S. Setji, N.D. Holland, and L. Sanders Nonalcoholic steatohepatitis and nonalcoholic fatty liver disease in young women with polycystic ovary syndrome J Clin Endocrinol Metab 91 2006 1741 1747
19. M. Gambarin-Gelwan, S.V. Kinkhabwala, T.D. Schiano, C. Bodian, H.C. Yeh, and W. Futterweit Prevalence of nonalcoholic fatty liver disease in women with polycystic ovary syndrome Clin Gastroenterol Hepatol 5 2007 496 501
20. E. Lerchbaum, V. Schwetz, and A. Giuliani Assessment of glucose metabolism in polycystic ovary syndrome: HbAc or fasting glucose compared with the oral glucose tolerance test as a screening method Hum Reprod 28 2013 2537 2544
21. A.J. Brown, T.L. Setji, and L.L. Sanders Effects of exercise on lipoprotein particles in women with polycystic ovary syndrome Med Sci Sports Exerc 41 2009 497 504
22. A. Sokalska, P.C. Piotrowski, and I.J. Rzepczynska Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability J Clin Endocrinol Metab 95 2010 5390 5394
23. A.J. Cussons, G.F. Watts, T.A. Mori, and B.G.A. Stuckey Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: A randomized controlled trial employing proton magnetic resonance spectroscopy J Clin Endocrinol Metab 94 2009 3842 3848
24. B.G. Chittenden, G. Fullerton, A. Maheshwari, and S. Bhattacharya Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review Reprod Biomed Online 19 2009 398 405
25. R. Legro, S. Arslanian, and D. Ehrmann Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline J Clin Endocrinol Metab 98 2013 4565 4592
26. T. Tang, J.M. Lord, R.J. Norman, E. Yasmin, and A.H. Balen Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligoamenorrhea, and subfertility Cochrane Database Syst Rev 5 2012 CD003053
27. E. Hollinrake, A. Abreu, and M. Maifield Increased risk of depressive disorders in women with polycystic ovary syndrome Fertil Steril 87 2007 1369 1376
28. M. Mansson, J. Holte, and K. Landin-Wilhelmsen Women with polycystic ovary syndrome are often depressed or anxious-A case control study Psychoneuroendocrinology 33 2008 1132 1138
29. K. Kroenke, R.L. Spitzer, and J.B. Williams The Patient Health Questionnaire-2: validity of a two-item depression screener Med Care 41 2003 1284 1292
30. R. Azziz, K.S. Woods, and R. Reyna The prevalence and features of the polycystic ovary syndrome in an unselected population J Clin Endocrinol Metab 89 2004 2745 2749
31. O. Lidegaard, L.H. Nielsen, and C.W. Skovlund Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9 BMJ 343 2011 d6423
32. S.T. Bird, A.G. Hartzema, and J.M. Brophy Risk of venous thromboembolism in women with polycystic ovary syndrome: a population-based matched cohort analysis Can Med Assoc J 185 2013 E115 E120
33. P. Moghetti, F. Tosi, and A. Tosti Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial J Clin Endocrinol Metab 85 2000 89 94
34. J.A.B. Balfour, and K. McClellan Topical eflornithine Am J Clin Dermatol 2 2001 197 201
35. R. Azziz, D. Ehrmann, and R.S. Legro Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial J Clin Endocrinol Metab 86 2001 1626 1632
36. E. Kousta, D.M. White, and S. Franks Modern use of clomiphene citrate in induction of ovulation Hum Reprod Update 4 1997 359 365
37. R.S. Legro, H.X. Barnhart, and W.D. Schlaff Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome N Engl J Med 356 2007 551 566
38. G.S. Ghazeeri, A.H. Nassar, Z. Younes, and J.T. Awwad Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview Acta Obstet Gynecol Scand 91 2012 658 678
39. E. Vanky, S. Stridslev, and R. Heimstad Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study J Clin Endocrinol Metab 95 2010 E448 E455
40. A.N. Vgontzas, R.S. Legro, and E.O. Bixler Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: Role of insulin resistance J Clin Endocrinol Metab 86 2001 517 520
41. E. Tasali, F. Chapotot, and R. Leproult Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome J Clin Endocrinol Metab 96 2011 365 374