A novel, potentdual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy

FASEB Journal

Volumn 28, Issue 8, 2014, Pages 3564-3578

  Kataoka, Shinsuke ^a   Baba, Atsuyo ^b   Suda, Yoshimitsu ^c   Takii, Ryosuke ^b   Hashimoto, Munetaka ^b   Kawakubo, Tomoyo ^b   Asao, Tetsuji ^c   Kadowaki, Tomoko ^b   Yamamoto, Kenji ^b  

^a LION CORPORATION   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Infectious diseases; Pathogen; Protease; Protease inhibitor

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; GINGIPAIN R; LYS GINGIPAIN; UNCLASSIFIED DRUG; ADHESIN; ARGINGIPAIN, PORPHYROMONAS GINGIVALIS; CARBOBENZOXY GLU LYS CO ARG CO NH(CH2)2PH; CARBOBENZOXY-GLU-LYS-CO-ARG-CO-NH(CH2)2PH; CYSTEINE PROTEINASE; CYTOKINE; LYS-GINGIPAIN; OLIGOPEPTIDE; PROTEINASE; PROTEINASE INHIBITOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DISEASE COURSE; DRUG DESIGN; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GINGIVITIS; GUINEA PIG; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; ANIMAL; CAPILLARY PERMEABILITY; CELL ADHESION; CULTURE MEDIUM; CYTOLOGY; DOG; DRUG EFFECT; DRUG SCREENING; ENZYME SPECIFICITY; ENZYMOLOGY; FIBROBLAST; INFECTIOUS DISEASES; MICROBIOLOGY; PATHOGENESIS; PATHOGENICITY; PERIODONTITIS; PROTEIN DEGRADATION; SECRETION (PROCESS); SYNTHESIS; UMBILICAL VEIN ENDOTHELIAL CELL; VIRULENCE;

INFECTIOUS DISEASES; PATHOGEN; PROTEASE; PROTEASE INHIBITOR;

ADHESINS, BACTERIAL; ANIMALS; CAPILLARY PERMEABILITY; CELL ADHESION; CULTURE MEDIA, CONDITIONED; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; CYTOKINES; DISEASE PROGRESSION; DOGS; DRUG EVALUATION, PRECLINICAL; FIBROBLASTS; GUINEA PIGS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; OLIGOPEPTIDES; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PROTEOLYSIS; SUBSTRATE SPECIFICITY; VIRULENCE;

EID: 84905235133     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-252130     Document Type: Article

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