Role of the intracellular nucleoside transporter ENT3 in transmitter and high K+ stimulation of astrocytic ATP release investigated using siRNA against ENT3

ASN Neuro

Volumn 6, Issue 4, 2014, Pages

  Song, Dan ^a   Xu, Junnan ^a   Bai, Qiufang ^a   Cai, Liping ^b   Hertz, Leif ^a   Peng, Liang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Adenosine; ATP release; ENT3; Gliotransmitter; Glutamate; SLC17A9

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 3; GLUTAMIC ACID; MESSENGER RNA; POTASSIUM ION; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; ASTROCYTE CULTURE; CONTROLLED STUDY; LUCIFERASE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNAPSE VESICLE;

EID: 84905234134     PISSN: None     EISSN: 17590914     Source Type: Journal    
DOI: 10.1177/1759091414543439     Document Type: Article

References (26)

1. Baldwin S. A., Yao S. Y., Hyde R. J., Ng A. M., Foppolo S., Barnes K.,. Young J. D (2005) Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. Journal of Biological Chemistry 280: 15880-15887.
2. Boison D (2013) Adenosine kinase: Exploitation for therapeutic gain. Pharmacological Reviews 65: 906-943.
3. Cahoy J. D., Emery B., Kaushal A., Foo L. C., Zamanian J. L., Christopherson K. S.,. Barres B. A (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function. The Journal of Neuroscience 28: 264-278.
4. Coco S., Calegari F., Pravettoni E., Pozzi D., Taverna E., Rosa P.,. Verderio C (2003) Storage and release of ATP from astrocytes in culture. Journal of Biological Chemistry 278: 1354-1362.
5. Doyle J. P., Dougherty J. D., Heiman M., Schmidt E. F., Stevens T. R., Ma G.,. Heintz N (2008) Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell 135: 749-762.
6. El Marjou M., Montalescot V., Buzyn A., & Geny B (2000) Modifications in phospholipase D activity and isoform expression occur upon maturation and differentiation in vivo and in vitro in human myeloid cells. Leukemia 14: 2118-2127.
7. + depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: A microelectrode biosensor study. British Journal of Pharmacology 167: 1003-1020.
8. Hertz L., Juurlink B. H. J., & Szuchet S (1985) Cell cultures. In: Lajtha A. (ed.) Handbook of neurochemistry. New York, NY: Plenum, pp. 603-661.
9. Hertz L., Xu J., & Peng L (2014) Glycogenolysis and purinergic signaling. In: Parpura V., Schousboe A., & Verkhratsky A. (eds) Glutamate and ATP at interface of metabolism and signaling in the brain. New York, NY: Springer, In press.
10. Juurlink B. H. J., & Hertz L (1992) Astrocytes. In: Boulton A. A., Baker G. B., & Walz W. (eds) Neuromethods in cell cultures. New York, NY: Humana Clifton, pp. 269-321.
11. Larsson M., Sawada K., Morland C., Hiasa M., Ormel L., Moriyama Y.,. Gundersen V (2012) Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release. Cerebral Cortex 22: 1203-1214.
12. Li B., Gu L., Hertz L., & Peng L (2013) Expression of nucleoside transporter in freshly isolated neurons and astrocytes from mouse brain. Neurochemical Research 38: 2351-2358.
13. Li B., Hertz L., & Peng L (2012) Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes. Neurochemistry International 61: 1325-1332.
14. Liu H., Sabirov R. Z., & Okada Y (2008) Oxygen-glucose deprivation induces ATP release via maxi-anion channels in astrocytes. Purinergic Signal 4: 147-154.
15. Lovatt D., Sonnewald U., Waagepetersen H. S., Schousboe A., He W., Lin J. H.,. Nedergaard M (2007) The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. Journal of Neuroscience 27: 12255-12266.
16. Matz H., & Hertz L (1989) Adenosine metabolism in neurons and astrocytes in primary cultures. Journal of Neuroscience Research 24: 260-267.
17. Nakagawa T., Otsuki N., Masai Y., Sasaki R., Tsukuda M., Nibu K (2008) Additive effects of oral fluoropyrimidine derivative S-1 and radiation on human hypopharyngeal cancer xenografts. Acta Oto-Laryngologica 128: 936-940.
18. Oya M., Kitaguchi T., Yanagihara Y., Numano R., Kakeyama M., Ikematsu K.,. Tsuboi T (2013) Vesicular nucleotide transporter is involved in ATP storage of secretory lysosomes in astrocytes. Biochemical and Biophysical Research Communications 438: 145-151.
19. Pangrsic T., Potokar M., Stenovec M., Kreft M., Fabbretti E., Nistri A.,. Zorec R (2007) Exocytotic release of ATP from cultured astrocytes. Journal of Biological Chemistry 282: 28749-28758.
20. Parkinson F. E., Damaraju V. L., Graham K., Yao S. Y., Baldwin S. A., Cass C. E.,. Young J. D (2011) Molecular biology of nucleoside transporters and their distributions and functions in the brain. Current Topics in Medicinal Chemistry 11: 948-972.
21. Parkinson F. E., Ferguson J., Zamzow C. R., & Xiong W (2006) Gene expression for enzymes and transporters involved in regulating adenosine and inosine levels in rat forebrain neurons, astrocytes and C6 glioma cells. Journal of Neuroscience Research 84: 801-808.
22. Peng L., Guo C., Wang T., Li B., Gu L., Wang Z (2013) Some methodologies for determination of astrocytic gene expression fail to give correct information for some genes. Frontiers in Endocrinology 4: 176.
23. Pryazhnikov E., & Khiroug L (2008) Sub-micromolar increase in [Ca2+]i triggers delayed exocytosis of ATP in cultured astrocytes. Glia 56: 38-49.
24. Studer F. E., Fedele D. E., Marowsky A., Schwerdel C., Wernli K., Vogt K.,. Boison D (2006) Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience 142: 125-137.
25. + concentrations. ASN Neuro 6(1): pii:e00132.
26. + homeostasis and glycogen usage in brain. Neurochemical Research 38: 472-485.