Modeling glucose and free fatty acid kinetics during insulin-modified intravenous glucose tolerance test in healthy humans: Role of counterregulatory response

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 307, Issue 3, 2014, Pages

  Thomaseth, Karl ^a   Brehm, Attila ^b   Pavan, Alessandra ^a   Pacini, Giovanni ^a   Roden, Michael ^c,d  

^a CNR   (Italy)

^b HANUSCH HOSPITAL   (Austria)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Hypoglycemia; Insulin sensitivity; Mathematical modeling; Nonesterified fatty acids

Indexed keywords

FATTY ACID; GLUCAGON; GLUCOSE; HORMONE; INSULIN;

ARTICLE; FATTY ACID METABOLISM; GLUCONEOGENESIS; GLUCOSE INFUSION; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; HYPOGLYCEMIA; INSULIN SENSITIVITY; INSULINEMIA; INTRAVENOUS GLUCOSE TOLERANCE TEST; KINETICS; MATHEMATICAL MODEL; NORMAL HUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM;

HYPOGLYCEMIA; INSULIN SENSITIVITY; MATHEMATICAL MODELING; NONESTERIFIED FATTY ACIDS;

ADULT; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIA; INSULIN; INSULIN RESISTANCE; MALE; MODELS, BIOLOGICAL; MODELS, THEORETICAL;

EID: 84905215895     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00314.2013     Document Type: Article

References (22)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 35: S64-S71, 2012.
2. Bergman RN, Ider YZ, Bowden CR, Cobelli C. Quantitative estimation of insulin sensitivity. Am J Physiol Endocrinol Metab Gastrointest Physiol 236: E667-E677, 1979.
3. Bonadonna RC, Groop LC, Zych K, Shank M, DeFronzo RA. Dosedependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol Endocrinol Metab 259: E736-E750, 1990.
4. Boston RC, Moate PJ. A novel minimal model to describe NEFA kinetics following an intravenous glucose challenge. Am J Physiol Regul Integr Comp Physiol 294: R1140-R1147, 2008.
5. Boston RC, Moate PJ. NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test. Am J Physiol Regul Integr Comp Physiol 295: R395-R403, 2008.
6. Brehm A, Thomaseth K, Bernroider E, Nowotny P, Waldhäusl W, Pacini G, Roden M. The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests. J Clin Endocrinol Metab 91: 2272-2278, 2006.
7. Kovatchev BP, Farhy LS, Cox DJ, Straume M, Yankov VI, Gonder-Frederick LA, Clarke WL. Modeling insulin-glucose dynamics during insulin induced hypoglycemia. Evaluation of glucose counterregulation. J Theor Med 1: 313-323, 1999.
8. Krebs M, Roden M. Nutrient-induced insulin resistance in human skeletal muscle. Curr Med Chem 11: 901-908, 2004.
9. Lunn DJ, Best N, Thomas A, Wakefield J, Spiegelhalter D. Bayesian analysis of population PK/PD models: general concepts and software. J Pharmacokinet Pharmacodyn 29: 271-307, 2002.
10. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24: 539-548, 2001.
11. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470, 1999.
12. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Tuner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
13. Pavan A, Thomaseth K, Valerio A. Modeling population kinetics of free fatty acids in isolated rat hepatocytes using Markov Chain Monte Carlo. Ann Biomed Eng 31: 854-866, 2003.
14. Periwal V, Chow CC, Bergman RN, Ricks M, Vega GL, Sumner AE. Evaluation of quantitative models of the effect of insulin on lipolysis and glucose disposal. Am J Physiol Regul Integr Comp Physiol 295: R1089-R1096, 2008.
15. Qvisth V, Hagström-Toft E, Enoksson S, Sherwin RS, Sjöberg S, Bolinder J. Combined hyperinsulinemia and hyperglycemia, but not hyperinsulinemia alone, suppress human skeletal muscle lipolytic activity in vivo. J Clin Endocrinol Metab 89: 4693-4700, 2004.
16. Pinheiro JC, Bates DM. Mixed-Effects Models in S and S-Plus. Springer, New York, 2000.
17. R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, ISBN 3-900051-07-0: http://www. R-project. org/. 2013.
18. Roy A, Parker RS. Dynamic modeling of free fatty acid, glucose, and insulin: an extended "minimal model". Diabetes Technol Ther 8: 617-626, 2006.
19. Schaffer JE. Lipotoxicity: when tissues overeat. Curr Opin Lipidol 14: 281-287, 2003.
20. Szendroedi J, Roden M. Ectopic lipids and organ function. Curr Opin Lipidol 20: 50-56, 2009.
21. Thomaseth K. Multidisciplinary modelling of biomedical systems. Comput Methods Programs Biomed 71: 189-201, 2003.
22. Thomaseth K, Pavan A. Model-based analysis of glucose and free fatty acid kinetics during glucose tolerance tests. In: Mathematical Modeling in Nutrition and Toxicology, edited by Hargrove JL, Berdanier CD. Athens, GA: Mathematical Biology Press, 2005, p. 21-40.