Modeling population kinetics of free fatty acids in isolated rat hepatocytes using Markov Chain Monte Carlo

Annals of Biomedical Engineering

Volumn 31, Issue 7, 2003, Pages 854-866

  Pavan, Alessandra ^a   Thomaseth, Karl ^a,c   Valerio, Anna ^b  

^a Inst of Syst Sci and Biomed Eng   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c CNR   (Italy)

Author keywords

Bayesian inference; Hierarchical models; MCMC; Metabolism

Indexed keywords

CELLS; COMPUTER SIMULATION; FATTY ACIDS; INSULIN; KETONES; MARKOV PROCESSES; MATHEMATICAL MODELS; MONTE CARLO METHODS; PHYSIOLOGY; POPULATION STATISTICS; REACTION KINETICS;

BAYESIAN INFERENCES;

METABOLISM;

FATTY ACID; KETONE BODY; OLEIC ACID;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; CULTURE TECHNIQUE; EVALUATION; KINETICS; LIVER CELL; MALE; METABOLISM; METHODOLOGY; MONTE CARLO METHOD; POPULATION DYNAMICS; PROBABILITY; RAT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; STATISTICS; VALIDATION STUDY; WISTAR RAT;

ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; FATTY ACIDS, NONESTERIFIED; HEPATOCYTES; KETONE BODIES; KINETICS; MALE; MARKOV CHAINS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MONTE CARLO METHOD; OLEIC ACID; POPULATION DYNAMICS; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STOCHASTIC PROCESSES;

EID: 0042266401     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1114/1.1581288     Document Type: Article

References (17)

1. Bortot, P., K. Thomaseth, and A. Salvan. Population toxico-kinetic analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin using Bayesian techniques. Stat. Med. 21:533-547, 2002.
2. Carson, E. R., C. Cobelli, and L. Finkelstein. The Mathematical Modeling of Metabolic and Endocrine Systems. New York: Wiley, 1983.
3. Gelman, A., J. B. Carlin, H. S. Stern, and D. B. Rubin. Bayesian Data Analysis. London: Chapman and Hall, 1995.
4. Gibaldi, M., and D. Perrier. Pharmacokinetics, 2nd ed. New York: Dekker, 1982.
5. Gilks, W. R., S. Richardson, and D. J. Spiegelhalter. Markov Chain Monte Carlo in Practice. London: Chapman and Hall, 1996.
6. Gilks, W. R., D. G. Clayton, D. G. Spiegelhalter, N. G. Best, A. J. McNeil, L. D. Sharpies, and A. J. Kirby. Modelling complexity: applications of Gibbs sampling in medicine. J. R. Stat. Soc. Ser. B. Methodol. 55:39-102, 1993.
7. Haario, H., E. Saksman, and J. Tammine. An adaptive Metropolis algorithm. Bernoulli 7:223-242, 2001.
8. Hundborg, H. H., M. Højbjerre, O. B. Christiansen, and S. L. Lauritzen. Familial tendency to foetal loss analysed with Bayesian graphical models by Gibbs sampling. Stat. Med. 19:2147-2168, 2000.
9. Laffel, L. Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab. Rev. 15:412-426, 1999.
10. Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974.
11. Pinheiro, J. C., and D. M. Bates. Mixed-Effects Models in S and S-PLUS. New York: Springer, 2000.
12. Shimuzu, S., K. Inque, and H. Yamada. Enzymatic microdetermination of serum free fatty acids. Anal. Biochem. 98:341-345, 1979.
13. Thomaseth, K., and A. Pavan. Population kinetics of free fatty acid in isolated rat hepatocytes: A Bayesian analysis based on Markov chain Monte Carlo simulation. In: Simulation in the Health and Medical Sciences 2001, edited by J. G. Anderson, and M. Katzper. San Diego: SCS, 2001, pp. 67-72.
14. Thomaseth, K., A. Pavan, G. Pacini, A. Avogaro, and A. Valerio. Free fatty acid disposal and ketone body production in isolated rat hepatocytes: Effects of epinephrine and insulin assessed by population kinetics modeling. FASEB J. 15:750, 2001.
15. Valerio, A., D. Basso, L. Brigato, G. Ceolotto, G. Baldo, A. Tiengo, and M. Plebani. Glucose metabolic alterations in isolated and perfused rat hepatocytes induced by pancreatic cancer conditioned medium: A low molecular weight factor possibly involved. Biochem. Biophys. Res. Commun. 257:622-628, 1999.
16. Wakefield, J. C.. The Bayesian analysis of population PK models. J. Am. Stat. Assoc. 91:62-75, 1996.
17. Wakefield, J., L. Aarons, and A. Racin-Poon. The Bayesian approach to population pharmacokinetic/pharmacodynamic modeling. In: Case Studies in Bayesian Statistics, edited by B. P. Carlin, A. L. Carriquiry, C. Gatsonis, A. Gelman, R. E. Kass, I. Verdinelli, and M. West. New York: Springer, 1998.