Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Two-year follow-up of a prospective randomized trial

American Journal of Sports Medicine

Volumn 42, Issue 6, 2014, Pages 1384-1394

  Saris, Daniel ^a,b   Price, Andrew ^c   Widuchowski, Wojciech ^d   Bertrand Marchand, Marion ^e   Caron, Jacob ^f   Drogset, Jon Olav ^g   Emans, Pieter ^h   Podskubka, Ales ⁱ   Tsuchida, Anika ^a   Kili, Sven ^j   Levine, David ^k   Brittberg, Mats ^l  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d District Hospital of Orthopedics and Trauma Surgery   (Poland)

^e Chirurgie Arthrose Sport et Arthroscopie Polyclinique Saint Roch   (France)

^f Microvida Laboratory for Medical Microbiology and Immunology   (Netherlands)

^g TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^h MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ UNIVERSITY HOSPITAL BULOVKA   (Czech Republic)

^j Genzyme Biosurgery (now Sanofi Biosurgery)   (United Kingdom)

^k GENZYME CORPORATION   (United States)

^l Kungsbacka Hospital   (Sweden)

more..

Author keywords

Cartilage repair; Clinical outcomes; Knee; Matrix applied characterized autologous cultured chondrocytes (MACI) implant; Microfracture

Indexed keywords

ADULT; ARTICULAR CARTILAGE; AUTOTRANSPLANTATION; CARTILAGE CELL; CHONDROPLASTY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; INJURIES; KNEE; KNEE INJURIES; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROCEDURES; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TRANSPLANTATION; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; ARTHROPLASTY, SUBCHONDRAL; CARTILAGE, ARTICULAR; CHONDROCYTES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KNEE INJURIES; KNEE JOINT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84905189850     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546514528093     Document Type: Article

References (40)

1. Bachmann G, Basad E, Lommel D, Steinmeyer J MRT in the follow-up of matrix-guided autologous chondrocyte implantation (MACI®) and microfracture. Radiologe. 2004;44(8):773-782.
2. Basad E, Ishaque B, Bachmann G, Sturz H, Steinmeyer J Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthrosc. 2010;18(4):519-527.
3. Brittberg M Cell carriers as the next generation of cell therapy for cartilage repair: a review of the matrix-induced autologous chondrocyte implantation procedure. Am J Sports Med. 2010;38(6):1259-1271.
4. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331(14):889-895.
5. de Windt TS, Welsch GH, Brittberg M, et al Is magnetic resonance imaging reliable in predicting clinical outcome after articular cartilage repair of the knee? A systematic review and meta-analysis. Am J Sports Med. 2013;41(7):1695-1702.
6. Ebert JR, Robertson WB, Lloyd DG, Zheng MH, Wood DJ, Ackland T A prospective, randomized comparison of traditional and accelerated approaches to postoperative rehabilitation following autologous chondrocyte implantation: 2-year clinical outcomes. Cartilage. 2010;1(3):180-187.
7. Ebert JR, Robertson WB, Woodhouse J, et al Clinical and magnetic resonance imaging-based outcomes to 5 years after matrix-induced autologous chondrocyte implantation to address articular cartilage defects in the knee. Am J Sports Med. 2011;39(4):753-763.
8. Ebert JR, Smith A, Edwards PK, Hambly K, Wood DJ, Ackland TR Factors predictive of outcome 5 years after matrix-induced autologous chondrocyte implantation in the tibiofemoral joint. Am J Sports Med. 2013;41(6):1245-1254.
9. European Medicines Agency. Reflection paper on in-vitro cultured chondrocyte containing products for cartilage repair of the knee. April 8, 2010. Available at: http://www.ema.europa.eu/docs/en-GB/document-library/Scientific- guideline/2010/05/WC500090887.pdf. Accessed March 21, 2014.
10. Gavénis K, Schmidt-Rohlfing B, Mueller-Rath R, Andereya S, Schneider U In vitro comparison of six different matrix systems for the cultivation of human chondrocytes. In Vitro Cell Dev Biol Anim. 2006;42(5-6):159-167.
11. Gigante A, Bevilacqua C, Ricevuto A, Mattioli-Belmonte M, Greco F Membrane-seeded autologous chondrocytes: cell viability and characterization at surgery. Knee Surg Sports Traumatol Arthrosc. 2007;15:88-92.
12. Gill TJ. The treatment of articular cartilage defects using microfracture and debridement. Am J Knee Surg. 2000;13(1):33-40.
13. Gomoll AH, Probst C, Farr J, Cole BJ, Minas T Use of a type I/III bilayer collagen membrane decreases reoperation rates for symptomatic hypertrophy after autologous chondrocyte implantation. Am J Sports Med. 2009;37(SUPPL. 1):20S-23S.
14. Irrgang JJ, Anderson AF, Boland AL, et al Development and validation of the International Knee Documentation Committee subjective knee form. Am J Sports Med. 2001;29(5):600-613.
15. Knutsen G, Drogset JO, Engebretsen L, et al A randomized trial comparing autologous chondrocyte implantation with microfracture: findings at five years. J Bone Joint Surg Am. 2007;89(10):2105-2112.
16. Kreuz PC, Steinwachs MR, Erggelet C, et al Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthritis Cartilage. 2006;14(11):1119-1125.
17. Mainil-Varlet P, Van DB, Nesic D, Knutsen G, Kandel R, Roberts S A new histology scoring system for the assessment of the quality of human cartilage repair: ICRS II. Am J Sports Med. 2010;38(5):880-890.
18. Marlovits S, Aldrian S, Wondrasch B, et al Clinical and radiological outcomes 5 years after matrix-induced autologous chondrocyte implantation in patients with symptomatic, traumatic chondral defects. Am J Sports Med. 2012;40(10):2273-2280.
19. Marlovits S, Striessnig G, Resinger CT, et al Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging. Eur J Radiol. 2004;52(3):310-319.
20. Mastbergen SC, Saris DB, Lafeber FP Functional articular cartilage repair: here, near, or is the best approach not yet clear? Nat Rev Rheumatol. 2013;9(5):277-290.
21. Miller BS, Joseph TA, Barry EM, Rich VJ, Sterett WI Patient satisfaction after medial opening high tibial osteotomy and microfracture. J Knee Surg. 2007;20(2):129-133.
22. Minas T, Gomoll AH, Rosenberger R, Royce RO, Bryant T Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques. Am J Sports Med. 2009;37(5):902-908.
23. Mithoefer K, McAdams T, Williams RJ, Kreuz PC, Mandelbaum BR Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis. Am J Sports Med. 2009;37:2053-2063.
24. Mithoefer K, Saris DBF, Farr J, et al Guidelines for the design and conduct of clinical studies in knee articular cartilage repair: International Cartilage Repair Society recommendations based on current scientific evidence and standards of clinical care. Cartilage. 2011;2(2):100-121.
25. Mithoefer K, Williams RJ III, Warren RF, et al. The microfracture technique for the treatment of articular cartilage lesions in the knee: a prospective cohort study. J Bone Joint Surg Am. 2005;87(9):1911-1920.
26. Noyes FR, Barber SD, Mooar LA A rationale for assessing sports activity levels and limitations in knee disorders. Clin Orthop Relat Res. 1989;246:238-249.
27. Pestka JM, Bode G, Salzmann G, Sudkamp NP, Niemeyer P Clinical outcome of autologous chondrocyte implantation for failed microfracture treatment of full-thickness cartilage defects of the knee joint. Am J Sports Med. 2012;40(2):325-331.
28. Peterfy CG, Guermazi A, Zaim S, et al Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage. 2004;12(3):177-190.
29. Saris DB, Vanlauwe J, Victor J, et al Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med. 2009;37(SUPPL. 1):10S-19S.
30. Saris DB, Vanlauwe J, Victor J, et al Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008;36(2):235-246.
31. Sohn DH, Lottman LM, Lum LY, et al Effect of gravity on localization of chondrocytes implanted in cartilage defects. Clin Orthop Relat Res. 2002;394:254-262.
32. Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy. 2003;19(5):477-484.
33. Steadman JR, Rodkey WG, Briggs KK Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes. J Knee Surg. 2002;15(3):170-176.
34. Steadman JR, Rodkey WG, Singleton SB, Briggs KK Microfracture techinique for full-thickness chondral defects: technique and clinical results. Oper Tech Orthop. 1997;7(4):300-304.
35. US Department of Health and Human Services, Food and Drug Administration. Guidance for Industry: preparation of IDEs and INDs for products intended to repair or replace knee cartilage. December 2011. Available at: http://www.fda.gov/downloads/biologicsbloodvaccines/ guidancecomplianceregulatoryinformation/guidances/cellularandgenetherapy/ ucm288011.pdf. Accessed March 21, 2014.
36. Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J, Luyten FP Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Am J Sports Med. 2011;39(12):2566-2574.
37. Ware J Jr, Kosinski M, Keller SD A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220-233.
38. Widuchowski W, Widuchowski J, Faltus R, et al Long-term clinical and radiological assessment of untreated severe cartilage damage in the knee: a natural history study. Scand J Med Sci Sports. 2011;21(1):106-110.
39. Widuchowski W, Widuchowski J, Trzaska T Articular cartilage defects: study of 25,124 knee arthroscopies. Knee. 2007;14(3):177-182.
40. Zheng M-H, Willers C, Kirilak L, et al Matrix-induced autologous chondrocyte implantation (MACI®): biological and histological assessment. Tissue Eng. 2007;13(4):737-746.