Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder

Frontiers in Behavioral Neuroscience

Volumn 8, Issue JULY, 2014, Pages

  Brad Wilson, C ^a   McLaughlin, Leslie D ^a   Ebenezer, Philip J ^a   Nair, Anand R ^a   Dange, Rahul ^a   Harre, Joseph G ^b   Shaak, Thomas L ^b   Diamond, David M ^c,d   Francis, Joseph ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b KEESLER MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Elevated plus maze; Inflammation mediators; Norepinephrine; PTSD rat; Serotonin; Sertraline; SSRI

Indexed keywords

BETA ACTIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; MESSENGER RNA; NEUROTRANSMITTER; NORADRENALIN; SERTRALINE; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELEVATED PLUS MAZE TEST; HIPPOCAMPUS; MALE; MENTAL STRESS; NEUROMODULATION; NONHUMAN; NORADRENALIN BLOOD LEVEL; NORADRENERGIC SYSTEM; POSTTRAUMATIC STRESS DISORDER; PREDATOR STRESS; PREFRONTAL CORTEX; RAT; TASK PERFORMANCE; UPREGULATION;

EID: 84905179975     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2014.00256     Document Type: Article

References (55)

1. Agarwal, D., Welsch, M. A., Keller, J. N., and Francis, J. (2011). Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR. Basic Res. Cardiol. 106, 1069-1085. doi:10.1007/s00395-011-0231-7.
2. Alexopoulos, G. S., Hoptman, M. J., Yuen, G., Kanellopoulos, D. J., Seirup, K., Lim, K. O., et al. (2013). Functional connectivity in apathy of late-life depression: a preliminary study. J. Affect. Disord. 149, 398-405. doi:10.1016/j.jad.2012. 11.023.
3. American, Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th Edn. Washington DC: APA.
4. Arora, R. C., Fichtner, C. G., O'Connor, F., and Crayton, J. W. (1993). Paroxetine binding in the blood platelets of post-traumatic stress disorder patients. Life Sci. 53, 919-928. doi:10.1016/0024-3205(93)90444-8.
5. Benarroch, E. E. (2009). The locus ceruleus norepinephrine system: functional organization and potential clinical significance. Neurology 73, 1699-1704. doi:10.1212/WNL.0b013e3181c2937c.
6. Berumen, L. C., Rodriguez, A., Miledi, R., and Garcia-Alcocer, G. (2012). Serotonin receptors in hippocampus. Scientific World Journal 2012:823493.doi:10. 1100/2012/823493.
7. Bourin, M., Petit-Demouliere, B., Dhonnchadha, B. N., and Hascoet, M. (2007). Animal models of anxiety in mice. Fundam. Clin. Pharmacol. 21, 567-574. doi:10.1111/j.1472-8206.2007.00526.x.
8. Bracha, H. S., Garcia-Rill, E., Mrak, R. E., and Skinner, R. (2005). Postmortem locus coeruleus neuron count in three American veterans with probable or possible war-related PTSD. J. Neuropsychiatry Clin. Neurosci. 17, 503-509.doi:10. 1176/appi.neuropsych.17.4.503.
9. Brewin, C. R., Andrews, B., and Valentine, J. D. (2000). Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J. Consult. Clin. Psychol. 68, 748-766. doi:10.1037/0022-006x.68.5.748.
10. Chrousos, G. P. (2000). Stress, chronic inflammation and emotional and physical well-being: concurrent effects and chronic sequelae. J. Allergy Clin. Immunol. 106(Suppl. 5), S275-S291. doi:10.1067/mai.2000.11 0163.
11. Davidson, J. R., Rothbaum, B. O., van der Kolk, B. A., Sikes, C. R., and Farfel, G. M. (2001). Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch. Gen. Psychiatry 58, 485-492. doi: 10.1001/archpsyc.58.5.485.
12. Delamothe, T.(2005). Happiness. BMJ 331, 1489-1490. doi:10.1136/bmj.331.7531. 1489.
13. Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., and Zoladz, P. R. (2007). The temporal dynamics model of emotional memory processing: a synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories and the Yerkes-Dodson law. Neural Plast. 2007:60803. doi:10.1155/2007/60803.
14. Doogan, D. P., and Caillard, V. (1992). Sertraline in the prevention of depression. Br. J. Psychiatry 160, 217-222. doi:10.1192/bjp.160.2.217.
15. Dubovsky, S. L. (1994). Beyond the serotonin reuptake inhibitors: rationales for the development of new serotonergic agents. J. Clin. Psychiatry 55, 34-44.
16. Elks, C. M., and Francis, J. (2010). Central adiposity, systemic inflammation and the metabolic syndrome. Curr. Hypertens. Rep. 12, 99-104. doi:10.1007/s11906-010-0096-4.
17. Finlay, J. M., Zigmond, M. J., and Abercrombie, E. D. (1995). Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: effects of diazepam. Neuroscience 64, 619-628. doi:10.1016/0306-4522(94)00331-x.
18. Fisher, P. M., Price, J. C., Meltzer, C. C., Moses-Kolko, E. L., Becker, C., Berga, S. L., et al. (2011). Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity. Biol. Mood Anxiety Disord. 1:2. doi:10.1186/2045-5380-1-2.
19. Francis, G. S., Cohn, J. N., Johnson, G., Rector, T. S., Goldman, S., and Simon, A. (1993). Plasma norepinephrine, plasma renin activity and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA cooperative studies group. Circulation 87(Suppl. 6), 40- 48.
20. Friedman, M. J., Marmar, C. R., Baker, D. G., Sikes, C. R., and Farfel, G. M. (2007). Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a department of veterans affairs setting. J. Clin. Psychiatry 68, 711-720. doi:10.4088/jcp.v68n0508.
21. Ganguly, P. K., Dhalla, K. S., Innes, I. R., Beamish, R. E., and Dhalla, N. S. (1986). Altered norepinephrine turnover and metabolism in diabetic cardiomyopathy. Circ. Res. 59, 684-693. doi:10.1161/01.res.59.6.684.
22. Geracioti, T. D. Jr., Baker, D. G., Ekhator, N. N., West, S. A., Hill, K. K., Bruce, B., et al. (2001). CSF norepinephrine concentrations in posttraumatic stress disorder. Am. J. Psychiatry 158, 1227-1230. doi:10.1176/appi.ajp.158.8. 1227.
23. Geracioti, T. D. Jr., Jefferson-Wilson, L., Strawn, J. R., Baker, D. G., Dashevsky, B. A., Horn, P. S., et al. (2013). Effect of traumatic imagery on cere- brospinal fluid dopamine and serotonin metabolites in posttraumatic stress disorder. J. Psychiatr. Res. 47, 995-998. doi:10.1016/j.jpsychires.2013.01.023.
24. Heyes, M. P., Saito, K., Crowley, J. S., Davis, L. E., Demitrack, M. A., Der, M., et al. (1992). Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain 115(Pt. 5), 1249-1273. doi:10.1093/brain/115.5.1249.
25. Joca, S. R., Ferreira, F. R., and Guimaraes, F. S. (2007). Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems. Stress 10, 227-249. doi:10.1080/102538907012 23130.
26. Jurgens, C. W., Rau, K. E., Knudson, C. A., King, J. D., Carr, P. A., Porter, J. E., et al. (2005). Beta1 adrenergic receptor-mediated enhancement of hippocampal CA3 network activity. J. Pharmacol. Exp. Ther. 314, 552-560. doi:10.1124/jpet.105. 085332.
27. Kim, J. J., and Diamond, D. M. (2002). The stressed hippocampus, synaptic plasticity and lost memories. Nat. Rev. Neurosci. 3, 453-462. doi:10.1038/nrn849.
28. Korte, S. M., and De Boer, S. F. (2003). A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-maze. Eur. J. Pharmacol. 463, 163-175. doi:10.1016/s0014-2999(03)01279-2.
29. Liberzon, I., Abelson, J. L., Flagel, S. B., Raz, J., and Young, E. A. (1999). Neu-roendocrine and psychophysiologic responses in PTSD: a symptom provocation study. Neuropsychopharmacology 21, 40-50. doi:10.1016/s0893-133x(98) 00128-6.
30. Maj, J., and Rogoz, Z. (1999). Synergistic effect of pramipexole and sertraline in the forced swimming test. Pol. J. Pharmacol. 51, 471-475.
31. McGeer, P. L., Eccles, J. C., and McGeer, E. (1987). Molecular Neuroanatomy of the Mammalian Brain. 2nd Edn. New York and London: Plenum Press.
32. Miller, I. W., Keitner, G. I., Schatzberg, A. F., Klein, D. N., Thase, M. E., Rush, A. J., et al. (1998). The treatment of chronic depression, part 3: psychosocial functioning before and after treatment with sertraline or imipramine. J. Clin. Psychiatry 59, 608-619. doi:10.4088/jcp.v59n1108.
33. Miller, A. H., Pariante, C. M., and Pearce, B. D. (1999). Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression. Adv. Exp. Med. Biol. 461, 107-116. doi:10.1007/978-0-585-37970-8_7.
34. Muldoon, M. F., Mackey, R. H., Williams, K. V., Korytkowski, M. T., Flory, J. D., and Manuck, S. B. (2004). Low central nervous system serotoner-gic responsivity is associated with the metabolic syndrome and physical inactivity. J. Clin. Endocrinol. Metab. 89, 266-271. doi:10.1210/jc.2003-031295.
35. Nemeroff, C. B., Bremner, J. D., Foa, E. B., Mayberg, H. S., North, C. S., and Stein, M. B. (2006). Posttraumatic stress disorder: a state-of-the-science review. J. Psychiatr. Res. 40, 1-21. doi:10.1016/j.jpsychires.2005.07.005.
36. Oosthuizen, F., Wegener, G., and Harvey, B. H. (2005). Nitric oxide as inflammatory mediator in post-traumatic stress disorder (PTSD): evidence from an animal model. Neuropsychiatr. Dis. Treat. 1, 109-123. doi:10.2147/nedt.1.2.109. 61049.
37. Pall, M. L., and Satterlee, J. D. (2001). Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome and posttraumatic stress disorder. Ann. N Y Acad. Sci. 933, 323-329. doi:10.1111/j.1749-6632.2001.tb05836.x.
38. Peirson, A. R., and Heuchert, J. W. (2000). Correlations for serotonin levels and measures of mood in a nonclinical sample. Psychol. Rep. 87(3 Pt. 1), 707-716. doi:10.2466/pr0.87.7.707-716.
39. Pellow, S., Chopin, P., File, S. E., and Briley, M. (1985). Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14, 149-167. doi:10.1016/0165-0270(85) 90031-7.
40. Schiepers, O. J., Wichers, M. C., and Maes, M. (2005). Cytokines and major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 29, 201-217. doi:10.1016/j.pnpbp.2004.11.003.
41. Shin, L. M., Rauch, S. L., and Pitman, R. K. (2006). Amygdala, medial prefrontal cortex and hippocampal function in PTSD. Ann. N Y Acad. Sci. 1071, 67-79. doi:10.1196/annals.1364.007.
42. Söndergaard, H. P., Hansson, L. O., and Theorell, T. (2004). The inflammatory markers C-reactive protein and serum amyloid A in refugees with and without posttraumatic stress disorder. Clin. Chim. Acta 342, 93-98. doi:10.1016/j.cccn.2003.12.019.
43. Southwick, S. M., Krystal, J. H., Morgan, C. A., Johnson, D., Nagy, L. M., Nicolaou, A., et al. (1993). Abnormal noradrenergic function in posttraumatic stress disorder. Arch. Gen. Psychiatry 50, 266-274. doi:10.1001/archpsyc.1993.01820160036003.
44. Southwick, S. M., Paige, S., Morgan, C. A. 3rd, Bremner, J. D., Krystal, J. H., and Charney, D. S. (1999). Neurotransmitter alterations in PTSD: catecholamines and serotonin. Semin. Clin. Neuropsychiatry 4, 242-248.
45. Watts, B. V., Schnurr, P. P., Mayo, L., Young-Xu, Y., Weeks, W. B., and Friedman, M. J. (2013). Meta-analysis of the efficacy of treatments for posttrau-matic stress disorder. J. Clin. Psychiatry 74, 541-550. doi:10.4088/JCP.12r0 8225.
46. Williams, E., Stewart-Knox, B., Helander, A., McConville, C., Bradbury, I., and Rowland, I. (2006). Associations between whole-blood serotonin and subjective mood in healthy male volunteers. Biol. Psychol. 71, 171-174. doi:10.1016/j.biopsycho.2005.03.002.
47. Wilson, C. B., Ebenezer, P. J., McLaughlin, L. D., and Francis, J. (2014a). Predator exposure/psychosocial stress animal model of post-traumatic stress disorder modulates neurotransmitters in the rat hippocampus and prefrontal cortex. PLoS One 9:e89104. doi:10.1371/journal.pone.0089104.
48. Wilson, C. B., McLaughlin, L. D., Ebenezer, P. J., Nair, A. R., and Francis, J. (2014b). Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder. Behav. Brain Res. 268C, 72-80. doi:10. 1016/j.bbr.2014.03.029.
49. Wilson, C. B., McLaughlin, L. D., Nair, A., Ebenezer, P. J., Dange, R., and Francis, J. (2013). Inflammation and oxidative stress are elevated in the brain, blood and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. PLoS One 8:e76146. doi:10.1371/journal. pone.0076146.
50. Yehuda, R., Southwick, S., Giller, E. L., Ma, X., and Mason, J. W. (1992). Urinary catecholamine excretion and severity of PTSD symptoms in vietnam combat veterans. J. Nerv. Ment. Dis. 180, 321-325. doi:10.1097/00005053-199205000-00006.
51. Zhang, Z., Cordeiro Matos, S., Jego, S., Adamantidis, A., and Seguela, P. (2013). Norepinephrine drives persistent activity in prefrontal cortex via synergistic alpha1 and alpha2 adrenoceptors. PLoS One 8: 66122. doi:10.1371/journal.pone.0066122.
52. Zoladz, P. R., Conrad, C. D., Fleshner, M., and Diamond, D. M. (2008). Acute episodes of predator exposure in conjunction with chronic social instability as an animal model of post-traumatic stress disorder. Stress 11, 259-281. doi:10.1080/10253890701768613.
53. Zoladz, P. R., and Diamond, D. M. (2013). Current status on behavioral and biological markers of PTSD: a search for clarity in a conflicting literature. Neurosci. Biobehav. Rev. 37, 860-895. doi:10.1016/j.neubiorev.
54. Zoladz, P. R., Fleshner, M., and Diamond, D. M. (2012). Psychosocial animal model of PTSD produces a long-lasting traumatic memory, an increase in general anxiety and PTSD-like glucocorticoid abnormalities. Psychoneuroendocrinology 37, 1531-1545. doi:10.1016/j.psyneuen.
55. Zoladz, P. R., Fleshner, M., and Diamond, D. M. (2013). Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. Prog. Neuropsychopharmacol. Biol. Psychiatry 44, 1-16. doi:10.1016/j.pnpbp.