Differential hexosamine biosynthetic pathway gene expression with type 2 diabetes

Molecular Genetics and Metabolism Reports

Volumn 1, Issue 1, 2014, Pages 158-169

  Coomer, Megan ^a   Essop, M Faadiel ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Fasting blood glucose; Gene expression; Hexosamine biosynthetic pathway; Leukocytes; Pre and overt diabetes

Indexed keywords

COMPLEMENTARY DNA; GLUCOSE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE 1; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE 2; HEMOGLOBIN A1C; HEXOSAMINE; N ACETYL BETA GLUCOSAMINIDASE; N ACETYLGLUCOSAMINYLTRANSFERASE; O LINKED BETA N ACETYLGLUCOSAMINYL TRANSFERASE; RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARBOHYDRATE SYNTHESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DNA SYNTHESIS; ETHNIC DIFFERENCE; FEMALE; GENE CONTROL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HEXOSAMINE BIOSYNTHETIC PATHWAY; HUMAN; IMPAIRED GLUCOSE TOLERANCE; LEUKOCYTE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA PURIFICATION; BIOSYNTHESIS; BLOOD SAMPLING; CAUCASIAN; MAJOR CLINICAL STUDY;

EID: 84905161833     PISSN: None     EISSN: 22144269     Source Type: Journal    
DOI: 10.1016/j.ymgmr.2014.03.003     Document Type: Article

References (29)

1. D.C. Love, and J.A. Hanover The hexosamine signaling pathway: deciphering the "O-GlcNAc code" Sci. STKE 312 2005 re13
2. T. Lefebvre et al. Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease Biochim. Biophys. Acta 1800 2010 67 79
3. M.R. Bond, and J.A. Hanover O-GlcNAc cycling: a link between metabolism and chronic disease Annu. Rev. Nutr. 33 2013 205 229
4. Z. Wang, M. Gucek, and G.W. Hart Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc Proc. Natl. Acad. Sci. U. S. A. 105 37 2008 13793 13798
5. L.K. Kreppel, M.A. Blomberg, and G.W. Hart Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats J. Biol. Chem. 272 1997 9308 9315 (Pubitemid 27154943)
6. Y. Gao, L. Wells, F.I. Comer, G.J. Parker, and G.W. Hart Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic N-acetylglucosaminidase from human brain J. Biol. Chem. 276 2001 9838 9845
7. G. Veerababu et al. Overexpression of glutamine:fructose-6- phosphateamidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance Diabetes 49 2000 2070 2078
8. N. Fülöp, R.B. Marchase, and J.C. Chatham Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system Cardiovasc. Res. 73 2007 288 297 (Pubitemid 44937687)
9. T. Oki, K. Yamazaki, J. Kuromitsu, M. Okada, and I. Tanaka cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse Genomics 57 2 1999 227 234 (Pubitemid 29205498)
10. M. Brownlee Biochemistry and molecular cell biology of diabetic complications Nature 414 2001 813 820 (Pubitemid 34000785)
11. M. Buse Hexosamines, insulin resistance and the complications of diabetes: current status Am. J. Physiol. 290 1 2006 E1 E8
12. K. Park, C.D. Saudek, and G.W. Hart Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes Diabetes 59 7 2010 1845 1850
13. C. Springhorn, T. Matsha, R. Erasmus, and M.F. Essop Exploring leukocyte O-GlcNAcylation as a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus J. Clin. Endocrinol. Metab. 97 2012 4640 4649
14. D.M. Lehman et al. A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-β-d glucosaminidase is associated with type 2 diabetes in Mexican Americans Diabetes 54 4 2005 1214 1221 (Pubitemid 40446339)
15. X. Yang et al. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance Nature 451 2008 964 969 (Pubitemid 351301737)
16. R. Dentin et al. Hepatic glucose sensing via the CREB coactivator CRTC2 Science 319 5868 2008 1402 1405 (Pubitemid 351354877)
17. S. Marshall, V. Bacote, and R.R. Traxinger Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance J. Biol. Chem. 266 1991 4706 4712 (Pubitemid 21909414)
18. J.A. Hanover, M.W. Krause, and D.C. Love The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine Biochim. Biophys. Acta 1800 2010 80 95
19. B.D. Lazarus, D.C. Love, and J.A. Hanover Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates Glycobiology 16 5 2006 415 421
20. V. Srinivasan Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: inter-relationships with hyperglycaemia and oxidative stress Clin. Biochem. 40 2007 952 957 (Pubitemid 47301789)
21. J.A. George Should haemoglobin A1c be used for the diagnosis of diabetes mellitus in South Africa? J. Endocrinol. Metab. Diab. SA 16 2011 122 127
22. K. Vosseller, L. Wells, M.D. Lane, and G.W. Hart Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes Proc. Natl. Acad. Sci. U. S. A. 99 8 2002 5313 5318 (Pubitemid 34411545)
23. C. Butkinaree, K. Park, and G.W. Hart O-linked β-N-acetylglucosamine (O-GlcNAc): extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress Biochim. Biophys. Acta 1800 2010 96 106
24. N. Fülöp et al. Impact of type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart Am. J. Physiol. Cell Physiol. 292 4 2007 C1370 C1378
25. J.A. Hanover et al. Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene Arch. Biochem. Biophys. 409 2003 287 297 (Pubitemid 36259596)
26. H. Zhang Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels J. Clin. Endocrinol. Metab. 89 2 2004 748 755 (Pubitemid 38269888)
27. R.T. Erasmus et al. High prevalence of diabetes mellitus and metabolic syndrome in a South African coloured population: baseline data of a study in Bellville, Cape Town SA Med. J. 102 11 2012 841 844
28. K.A. Robinson, M.L. Weinstein, G.E. Lindenmayer, and M.G. Buse Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver Diabetes 44 1995 1438 1446
29. Q. Chang et al. Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity J. Biol. Chem. 275 2000 21981 21987 (Pubitemid 30621772)