Identification and development of 2-methylimidazo[1,2-a]pyridine-3- carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 15, 2014, Pages 4223-4232

  Samala, Ganesh ^a   Nallangi, Radhika ^a   Devi, Parthiban Brindha ^a   Saxena, Shalini ^a   Yadav, Renu ^a   Sridevi, Jonnalagadda Padma ^a   Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

2 Methylimidazo 1,2 a pyridine 3 carbohydrazide; Cytotoxicity; Pantothenate synthetase; Tuberculosis

Indexed keywords

2 METHYL N PHENYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOXAMIDE; 2 METHYL N' (3 NITROBENZOYL)IMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYL N' (3,4,5 TRIMETHOXYBENZYLIDENE)IMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYL N' (4 METHYLBENZOYL)IMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYL N' (4 METHYLBENZYLIDENE)IMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYL N' (4 NITROBENZYLIDENE)IMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYL N' (4 PHENOXYBENZOYL)IMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYL N' [4 (TRIFLUOROMETHYL)BENZYLIDENE]IMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYLIMIDAZO [1,2 A]PYRIDINE 3 CARBOXAMIDE DERIVATIVE; 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; ISONIAZID; N' (1 NAPHTHOYL) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (2 METHOXYBENZOYL) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (2,4 DICHLOROBENZOYL) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (3,5 DINITROBENZOYL) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (4 BROMOBENZYLIDENE) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (4 FLUOROBENZYLIDENE) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (4 HYDROXYBENZYLIDENE) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (4 METHOXYBENZYLIDENE) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (CYCLOHEXANECARBONYL) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' (FURAN 2 CARBONYL) 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' BENZOYL 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' BENZYLIDENE 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; N' [4 (BENZYLOXY)BENZYLIDENE] 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 CARBOHYDRAZIDE; PANTOTHENATE SYNTHETASE; PANTOTHENIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; AMIDE; BACTERIAL PROTEIN; IMIDAZO(1,2-A)PYRIDINE; PEPTIDE SYNTHASE; PYRIDINE DERIVATIVE; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DYNAMICS; MOUSE; SYNTHESIS;

AMIDES; ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; CELL SURVIVAL; ENZYME INHIBITORS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DYNAMICS SIMULATION; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905123430     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.05.038     Document Type: Article

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