An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas

Clinical and Experimental Medicine

Volumn 14, Issue 3, 2014, Pages 331-336

  Kim, Bora ^a   Lee, Jae Ho ^a   Park, Jong Wook ^a   Kwon, Taeg Kyu ^a   Baek, Seong Kyu ^a   Hwang, Ilseon ^a   Kim, Shin ^a  

^a Keimyung University   (South Korea)

Author keywords

AGO2; Colorectal cancer; DGCR8; MicroRNA biogenesis

Indexed keywords

ARGONAUTE PROTEIN; DGCR8 PROTEIN, HUMAN; EIF2C2 PROTEIN, HUMAN; RNA BINDING PROTEIN;

ADULT; AGED; BIOSYNTHESIS; COLORECTAL TUMOR; GENE EXPRESSION PROFILING; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADULT; AGED; ARGONAUTE PROTEINS; COLORECTAL NEOPLASMS; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA-BINDING PROTEINS; UP-REGULATION;

EID: 84905109222     PISSN: 15918890     EISSN: 15919528     Source Type: Journal    
DOI: 10.1007/s10238-013-0243-8     Document Type: Article

References (26)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893-2917. doi:10.1002/ijc.25516
2. Jung KW, Park S, Kong HJ, Won YJ, Lee JY, Seo HG, Lee JS (2012) Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2009. Cancer Res Treat 44(1):11-24. doi:10.4143/crt.2012.44.1.11
3. Grade M, Becker H, Liersch T, Ried T, Ghadimi BM (2006) Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact. Cell Oncol 28(3):71-84 (Pubitemid 43999883)
4. Li PY, He FC, Zhou GQ (2011) Association of human microRNA related genetic variations with cancer. Yi Chuan 33(8):870-878
5. Schmittgen TD (2008) Regulation of microRNA processing in development, differentiation and cancer. J Cell Mol Med 12(5B):1811-1819. doi:10.1111/j.1582-4934.2008.00483.x
6. Shen J, Stass SA, Jiang F (2012) MicroRNAs as potential biomarkers in human solid tumors. Cancer Lett. doi:10.1016/j.canlet.2012.11.001
7. Papachristou DJ, Korpetinou A, Giannopoulou E, Antonacopoulou AG, Papadaki H, Grivas P, Scopa CD, Kalofonos HP (2011) Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas. Virchows Arch 459(4):431-440. doi:10.1007/s00428-011-1119-5
8. Sand M, Skrygan M, Georgas D, Arenz C, Gambichler T, Sand D, Altmeyer P, Bechara FG (2012) Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer. Mol Carcinog 51(11):916-922. doi:10.1002/mc.20861
9. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281-297
10. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R (2004) The microprocessor complex mediates the genesis of microRNAs. Nature 432(7014):235-240. doi:10.1038/nature03120 (Pubitemid 39545855)
11. Rana TM (2007) Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol 8(1):23-36. doi:10.1038/nrm2085
12. Shaikhibrahim Z, Lindstrot A, Ochsenfahrt J, Fuchs K, Wernert N (2013) Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines. Int J Mol Med 31(1):21-25. doi:10.3892/ijmm.2012.1173
13. Zhang X, Cairns M, Rose B, O'Brien C, Shannon K, Clark J, Gamble J, Tran N (2009) Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland. Int J Cancer 124(12):2855-2863. doi:10.1002/ijc.24298
14. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3(6):1101-1108 (Pubitemid 351818697)
15. Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol RW, Dhir R (2006) Up-regulation of dicer, a component of the microRNA machinery, in prostate adenocarcinoma. Am J Pathol 169(5):1812-1820. doi:10.2353/ajpath.2006. 060480 (Pubitemid 351182010)
16. Mockenhaupt S, Schurmann N, Grimm D (2011) When cellular networks run out of control: global dysregulation of the RNAi machinery in human pathology and therapy. Prog Mol Biol Transl Sci 102:165-242. doi:10.1016/B978-0-12-415795-8. 00006-4
17. Dewi DL, Ishii H, Haraguchi N, Nishikawa S, Kano Y, Fukusumi T, Ozaki M, Saito T, Sakai D, Satoh T, Doki Y, Mori M (2012) Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells. Int J Mol Med 29(6):1060-1064. doi:10.3892/ijmm.2012.945
18. Faggad A, Kasajima A, Weichert W, Stenzinger A, Elwali NE, Dietel M, Denkert C (2012) Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer. Histopathology. doi:10.1111/j.1365-2559.2011.04110.x
19. Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, Pennacchio LA, Cheng JF, Nick AM, Deavers MT, Mourad-Zeidan A, Wang H, Mueller P, Lenburg ME, Gray JW, Mok S, Birrer MJ, Lopez-Berestein G, Coleman RL, Bar-Eli M, Sood AK (2008) Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 359(25):2641-2650. doi:10.1056/NEJMoa0803785
20. Dedes KJ, Natrajan R, Lambros MB, Geyer FC, Lopez-Garcia MA, Savage K, Jones RL, Reis-Filho JS (2011) Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer. Eur J Cancer 47(1):138-150. doi:10.1016/j.ejca.2010.08.007
21. Faber C, Horst D, Hlubek F, Kirchner T (2011) Overexpression of Dicer predicts poor survival in colorectal cancer. Eur J Cancer 47(9):1414-1419. doi:10.1016/j.ejca.2011.01.006
22. Vincenzi B, Zoccoli A, Schiavon G, Iuliani M, Pantano F, Dell'aquila E, Ratta R, Muda AO, Perrone G, Brunelli C, Correale P, Riva E, Russo A, Loupakis F, Falcone A, Santini D, Tonini G (2013) Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients. Eur J Cancer 49(6):1501-1508. doi:10.1016/j.ejca.2012.11.014
23. Pellegrino L, Jacob J, Roca-Alonso L, Krell J, Castellano L, Frampton AE (2013) Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancers. Expert Rev Anticancer Ther 13(1):21-27. doi:10.1586/era.12.150
24. Jafarnejad SM, Sjoestroem C, Martinka M, Li G (2013) Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma. Mod Pathol. doi:10.1038/modpathol.2012.225
25. Diaz-Garcia CV, Agudo-Lopez A, Perez C, Lopez-Martin JA, Rodriguez-Peralto JL, de Castro J, Cortijo A, Martinez-Villanueva M, Iglesias L, Garcia-Carbonero R, Fresno Vara JA, Gamez-Pozo A, Palacios J, Cortes-Funes H, Paz-Ares L, Agullo-Ortuno MT (2013) DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification. Carcinogenesis. doi:10.1093/carcin/bgt022
26. Sand M, Skrygan M, Georgas D, Sand D, Gambichler T, Altmeyer P, Bechara FG (2012) The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi. Cell Tissue Res 350(1):119-126. doi:10.1007/s00441-012-1446-0