Pooled nucleic acid testing increases the diagnostic yield of acute HIV infections in a high-risk population compared to 3rd and 4th generation HIV enzyme immunoassays

Journal of Clinical Virology

Volumn 61, Issue 1, 2014, Pages 132-137

  Krajden, Mel ^a,b   Cook, Darrel ^a   Mak, Annie ^a   Chu, Ken ^a   Chahil, Navdeep ^a   Steinberg, Malcolm ^a,c   Rekart, Michael ^b   Gilbert, Mark ^a,b  

^a BRITISH COLUMBIA CENTRE FOR DISEASE CONTROL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c SIMON FRASER UNIVERSITY   (Canada)

Author keywords

4th generation EIA; Acute HIV; HIV diagnostics; Pooled nucleic acid testing

Indexed keywords

VIRUS RNA; NUCLEIC ACID;

ARTICLE; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ENZYME IMMUNOASSAY; HIGH RISK POPULATION; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOASSAY ANALYZER; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MEN WHO HAVE SEX WITH MEN; POOLED NUCLEIC ACID TESTING; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEROCONVERSION; ADULT; AGED; COMPARATIVE STUDY; EVALUATION STUDY; GENETICS; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; MIDDLE AGED; MOLECULAR DIAGNOSIS; PROCEDURES; VIROLOGY; YOUNG ADULT;

ADULT; AGED; HIV; HIV INFECTIONS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; NUCLEIC ACIDS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84905106110     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2014.06.024     Document Type: Article

References (27)

1. Brenner B.G., Roger M., Routy J.P., Moisi D., Ntemgwa M., Matte C., et al. High rates of forward transmission events after acute/early HIV-1 infection. J Infect Dis 2007, 195(7):951-959.
2. Volz E.M., Ionides E.M., Romero-Severson E.O., Brandt M.-G., Mokotoff E., Koopman J.S. HIV-1 Transmission during early infection in men who have sex with men: a phylodynamic analysis. PLoS Med 2013, 10(12):e1001568. http://dx.doi:10.1371/journal.pmed.1001568.
3. Cohen M.S., Shaw G.M., McMichael A.J., Haynes B.F. Acute HIV-1 infection. N Engl J Med 2011, 364(20):1943-1954. http://dx.doi:10.1056/NEJMra1011874.
4. Yerly S., Hirschel B. Diagnosing acute HIV infection. Expert Rev Anti-Infect Ther 2012, 10(1):31-41. 10.1586/eri.11.154.
5. Pilcher C.D., Fiscus S.A., Nguyen T.Q., Foust E., Williams D., Ashby R., et al. Detection of acute infections during HIV testing in North Carolina. N Engl J Med 2005, 352(18):1873-1883.
6. Gilbert M., Cook D., Steinberg M., Kwag M., Robert W., Doupe G., et al. Targeting screening and social marketing to increase detection of acute HIV infection in MSM in Vancouver, British Columbia. AIDS 2013, 27(16):2649-2654.
7. Fiebig E.W., Wright D.J., Rawal B.D., Garrett P.E., Schumacher R.T., Peddada L., et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 2003, 17(13):1871-1879.
8. Pandori M.W., Branson B.M. 2010 HIV diagnostics conference. Exp Rev Anti-Infect Ther 2010, 8(6):631-633. 10.1586/eri.10.48.
9. Branson B.M., Mermin J. Establishing the diagnosis of HIV infection: new tests and a new algorithm for the United States. J Clin Virol 2011, 52:S3-S4.
10. Ramos E.M., Harb S., Dragavon J., Swenson P., Stekler J.D., Coombs R.W., et al. Performance of an alternative HIV diagnostic algorithm using the ARCHITECT HIV Ag/Ab Combo assay and potential utility of sample-to-cutoff ratio to discriminate primary from established infection. J Clin Virol 2013, 58(Suppl 1):e38-e43. http://dx.doi.org/10.1016/j.jcv.2013.08.014.
11. Masciotra S., Smith A.J., Youngpairoj A.S., Sprinkle P., Miles I., Sionean C., et al. Evaluation of the CDC proposed laboratory HIV testing algorithm among men who have sex with men (MSM) from five US metropolitan statistical areas using specimens collected in 2011. J Clin Virol 2013, 58(Suppl 1):e8-e12. http://dx.doi.org/10.1016/j.jcv.2013.09.002.
12. Geren K., Moore E., Tomlinson C., Hobohm D., Gardner A., Reardon-Maynard D., et al. Detection of Acute HIV Infection in two evaluations of a new HIV diagnostic testing algorithm - United States, 2011-2013. Morb Mortal Weekly Rep 2013, 62(24):489-494.
13. Stekler J.D., Swenson P.D., Coombs R.W., Dragavon J., Thomas K.K., Brennan C.A., et al. HIV testing in a high-incidence population: is antibody testing alone good enough?. Clin Infect Dis 2009, 49(3):444-453. http://dx.doi:10.1086/600043.
14. Hutchinson A.B., Patel P., Samson S.L., Farnham P.G., Sullivan T.J., Bennett B., et al. Cost-effectiveness of pooled nucleic acid amplification testing for acute HIV Infection after third-generation HIV antibody screening and rapid testing in the United States: a comparison of three public health settings. PLoS Med 2010, 7(9):e1000342. http://dx.doi:10.1371/journal.pmed.1000342.
15. Miller W.C., Leone P.A., McCoy S., Nguyen T.Q., Williams D.E., Pilcher C.D., et al. Targeted testing for acute HIV infection in North Carolina. AIDS 2009, 23(7):835-843.
16. Shepard C., Gallagher K., Bodach S.D., Kowalski A., Terzian A.S., Begier E., et al. Acute HIV infection - New York City, 2008. Morb Mortal Weekly Rep 2009, 58(46):1296-1299.
17. Sullivan T.J., Patel P., Hutchinson A., Etheridge S.F., Parker M.M. Evaluation of pooling strategies for acute HIV-1 infection screening using nucleic acid amplification testing. J Clin Microbiol 2011, 49(10):3667-3668. 10.1128/jcm.00650-11.
18. Westreich D.J., Hudgens D.J., Fiscus S.A., Pilcher C.D. Optimizing screening for acute human immunodeficiency virus infection with pooled nucleic acid amplification tests. J Clin Microbiol 2008, 46(5):1785-1792. 10.1128/jcm.00787-07.
19. Emerson B., Plough K., Pangloli A., Haq S., Serinaldi D., Bannister E., et al. Detection of acute HIV-1 infections utilizing NAAT technology in Dallas, Texas. J Clin Virol 2013, 58(Suppl 1):e48-e53. http://dx.doi.org/10.1016/j.jcv.2013.08.005.
20. Long E.F. HIV screening via fourth-generation immunoassay or nucleic acid amplification test in the United States: a cost-effectiveness analysis. PLoS ONE 2011, 6(11):e27625. http://dx.doi.org/10.1371%2Fjournal.pone.0027625.
21. Karris M.Y., Anderson C.M., Morris S.R., Smith D.M., Little S.J. Cost savings associated with testing of antibodies, antigens, and nucleic acids for diagnosis of acute HIV infection. J Clin Microbiol 2012, 50(6):1874-1878. 10.1128/jcm.00106-12.
22. Montaner J.S.G., Lima V.D., Harrigan P.R., Lourenco L., Yip B., Nosyk B., et al. Expansion of HAART coverage is associated with sustained decreases in HIV/AIDS morbidity, mortality and HIV transmission: the "HIV treatment as prevention" experience in a Canadian setting. PLoS ONE 2014, 9(2):e87872. http://dx.doi.org/10.1371%2Fjournal.pone.0087872.
23. Rondahl E., Gruber M., Joelsson S., Sundqvist M., Akerlind B., Cardell C., et al. The risk of HCV RNA contamination in serology screening instruments with a fixed needle for sample transfer. J Clin Virol 2014, in press. http://dx.doi.org/10.1016/j.jcv.2014.03.011.
24. Cragin L., Pan F., Peng S., Zenilman J., Green J., Doucet C., et al. Cost-effectiveness of a fourth-generation combination immunoassay for Human Immunodeficiency Virus (HIV) antibody and p24 antigen for the detection of HIV infections in the United States. HIV Clin Trials 2012, 13(1):11-22. 10.1310/hct1301-011.
25. Han X., Xu J., Chu Z., Dai D., Lu C., Wang X., et al. Screening acute HIV infections among Chinese men who have sex with men from voluntary counseling & testing centers. PLoS ONE 2011, 6(12):e28792.
26. Steward W., Remien R.H., Higgins J.A., Dubrow R., Pinkerton S.D., Sikkema K.J., et al. Behavior change following diagnosis with acute/early HIV infection - a move to serosorting with other HIV-infected individuals. The NIMH multisite acute HIV infection study: III. AIDS Behav 2009, 13(6):1054-1060. http://dx.doi.org/10.1007/s10461-009-9582-6.
27. Farnham P., Gopalappa C., Sansom S., Hutchinson A., Brooks J., Weidle P., et al. Updates of lifetime costs of care and quality-of-life estimates for HIV-infected persons in the United States: late versus early diagnosis and entry into care. J Acquir Immune Defic Syndr 2013, 64(2):183-189. 10.1097/QAI.0b013e3182973966.