Salt or sugar for your injured brain? A meta-analysis of randomised controlled trials of mannitol versus hypertonic sodium solutions to manage raised intracranial pressure in traumatic brain injury

Emergency Medicine Journal

Volumn 31, Issue 8, 2014, Pages 679-683

  Rickard, Annette ^a   Smith, J E ^b   Newell, P ^c   Bailey, A ^c   Kehoe, A ^a   Mann, C ^d  

^a DERRIFORD HOSPITAL   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF PLYMOUTH   (United Kingdom)

^d MUSGROVE PARK HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MANNITOL; SODIUM; SODIUM CHLORIDE; SUGAR; OSMOTIC DIURETIC AGENT;

CLINICAL TRIAL; HUMAN; INTRACRANIAL PRESSURE; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; TRAUMATIC BRAIN INJURY; BRAIN INJURY; COMPLICATION; DRUG EFFECTS; INTRACRANIAL HYPERTENSION; RANDOMIZED CONTROLLED TRIAL (TOPIC);

BRAIN INJURIES; DIURETICS, OSMOTIC; HUMANS; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MANNITOL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SALINE SOLUTION, HYPERTONIC;

EID: 84905101492     PISSN: 14720205     EISSN: 14720213     Source Type: Journal    
DOI: 10.1136/emermed-2013-202679     Document Type: Review

References (21)

1. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet 1975;1:480-4.
2. Juul N, Morris GF, Marshall SB, et al. Intracranial hypertension and cerebral perfusion pressure: influence on neurological deterioration and outcome in severe head injury. The Executive Committee of the International Selfotel Trial. J Neurosurg 2000;92:1-6. (Pubitemid 30022080)
3. Brain Trauma Foundation. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2007;24(Supp 1):1-116.
4. Bhardwaj A, Ulatowski JA. Hypertonic saline solutions in brain injury. Curr Opin Crit Care 2004;10:126-31. (Pubitemid 38519721)
5. Moher D, Liberati A, Tetzlaff J, et al. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement. PLoS Med 2009;6:e1000097.
6. Higgins JPT, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. Brit Med J 2011;18:d5928.
7. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. (Pubitemid 17189972)
8. Vialet R, Albanèse J, Thomachot L, et al. Isovolume hypertonic solutes (sodium chloride or mannitol) in the treatment of refractory posttraumatic intracranial hypertension: 2 mL/kg 7.5% saline is more effective than 2 mL/kg 20% mannitol. Crit Care Med 2003;31:1683-7. (Pubitemid 36714221)
9. Polushin IS, Krylov VV, Svistov DV, et al. Correction of intracranial hypertension syndrome using hyperosmolar solutions in patients with severe brain damage (multicenter randomised clinical study). Anesteziol Reanimatol 2009;5:4-8.
10. Battison C, Andrews PJD, Graham C, et al. Randomised, controlled trial on the effect of a 20% mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury. Crit Care Med 2005; 33:196-202. (Pubitemid 40116557)
11. Cottenceau V, Masson F, Mahamid E, et al. Comparison of effects of equiosmolar doses of mannitol and hypertonic saline on cerebral blood flow and metabolism in traumatic brain injury. J Neurotrauma 2011;28:2003-12.
12. Francony G, Fauvage B, Falcon D, et al. Equimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressure. Crit Care Med 2008;36:795-800.
13. Harutjunyan L, Holz C, Rieger A, et al. Efficiency of 7.2% hypertonic saline hydroxyethyl starch 200/0.5 versus mannitol 15% in the treatment of increased intracranial pressure in neurosurgical patients-a randomised clinical trial [ISRCTN62699180]. Crit Care 2005;9:R530-40.
14. Ichai C, Armando G, Orban J-C, et al. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med 2009;35:471-9.
15. Sakellaridis N, Pavlou E, Karatzas S, et al. Comparison of mannitol and hypertonic saline in the treatment of severe brain injuries. J Neurosurg 2011;114:545-8.
16. Kamel H, Navi BB, Nakagawa K, et al. Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials. Crit Care Med 2011;39:554-9.
17. Marmarou A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 2007;22:E1.
18. Mortazavi MM, Romeo AK, Deep A, et al. Hypertonic saline for treating raised intracranial pressure: literature review with meta-analysis. J Neurosurg 2012;116:210-21.
19. Kerwin AJ, Schinco MA, Tepas JJ, et al. The use of 23.4% hypertonic saline for the management of elevated intracranial pressure in patients with severe traumatic brain injury: a pilot study. J Trauma 2009;67:277-82.
20. Oddo M, Levine JM, Frangos S, et al. Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension. J Neurol Neurosurg Psychiatry 2009;80:916-20.
21. Ware ML, Nemani VM, Meeker M, et al. Effects of 23.4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary study. Neurosurgery 2005;57:727-36.